Study of Acid Phosphatase and Heamoglobin Level in Malarial and Non Malarial Fever Patients

Abstract

Background: Malaria is a mosquito borne disease. It is a major health hazard in India and other tropical countries. An estimated 198 million cases of malaria and 584 000 malaria deaths occurred in 2013. Acid phosphatase (ec 3.1.3.2, ACP) includes all the phosphatases with optimal activity below the pH of 7.0. ACP is present in lysosomes in all cells and exist extra-lysosomally in erythrocytes. Little is known about the levels of ACP in infectious diseases like malaria. So we undertook this study to know the Hb and ACP level in malarial patients.Methods: 60 subjects in the age group of 20 to 50 years were included in this study. These subjects were divided into 2 groups. Group 1 included 30 confirmed malaria fever patients. Group 2 included 30 non-malarial fever patients of same age & sex group. These selected subjects had no prostate problems, previous anaemia, or any other kind of bone disorder. Serum ACP was estimated using kit method Result:The serum ACP levels were significantly increased in malarial fever patients when compared with the non malaria fever patients (P=0.032). There is also statistical significant difference in the Hb levels between malarial and non-malarial fever patients Conclusion:Our results of increased levels of serum ACP and decreased Hb in malarial fever patients could be used as a marker for haemolysis & anemia. ACP may be used as an additional investigation in the diagnosis of malaria.