Study of acute transfusion reactions in a teaching hospital of Sikkim: A hemovigilance initiative

Sharma, Dhruva Kumar; Datta, Supratim; Gupta, Amlan

doi:10.4103/0253-7613.161257

Cited by 20 publications

(18 citation statements)

References 17 publications

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“…Studies conducted in other parts of India report a lesser volume in this regard since PCV was suspected in substantially less number of cases. [ 19 25 ] Other blood components, used in relatively less number of patients, were less frequently associated with TRs in the present study.…”

Section: Discussionmentioning

confidence: 50%

“…This incidence is higher as compared to that reported from other parts of the country, i.e., 0.05%–3.3%. [ 15 19 25 ] This may be attributed to intensive method of monitoring employed in the present work as compared to conventional reporting or retrospective analysis of records employed in other studies. Intensive monitoring can detect a larger number of adverse reactions since minor, less severe reactions are often not reported to blood bank by conventional reporting.…”

Section: Discussionmentioning

confidence: 94%

“…[ 16 24 27 28 ] Reaction was common with packed cells, most commonly used blood component in the present study since it is commonly observed with cellular blood components. [ 25 ] It is caused by white cell Ag-Ab interaction and release of cytokines during storage of blood components. Use of leukodepleted packed cells and platelets,[ 29 ] initiation of transfusion within 30 min of issue of blood component and cold chain maintenance are recommended to reduce the occurrence.…”

Section: Discussionmentioning

confidence: 99%

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Transfusion-related adverse reactions in pediatric and surgical patients at a tertiary care teaching hospital in India

Ghataliya

Kapadia

Desai

et al. 2017

Asian J Transfus Sci

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BACKGROUND:Use of blood and its components is lifesaving. However, their use is often associated with adverse events.OBJECTIVE:To analyze the pattern of adverse reactions associated with transfusion of blood and its components in pediatric and surgical patients at a tertiary care teaching hospital.MATERIALS AND METHODS:Patients receiving transfusion of blood or its components in a randomly selected unit each from Departments of Pediatrics, including thalassemia OPD and surgery, were monitored intensively for a period of 6 months. Clinical course, management, outcome, causality, severity, seriousness, and preventability of observed transfusion reactions (TRs) were analyzed.RESULTS:A total of 411 pediatric and 433 surgical patients received 594 and 745 transfusions respectively during the study period. Of these, TRs were observed in 69 (11.6%) children and 63 (8.4%) surgical patients. Majority of reactions in children (48, 69.5%) and surgical patients (51, 80.9%) were acute, developing within 24 h of transfusion. TRs were observed with packed cells (13.2%), cryoprecipitate (10%), platelet concentrate (14.3%) and fresh frozen plasma (1.3%) in pediatric patients and with packed cells (7.2%), whole blood (25%) and platelet concentrate (62.5%) in surgical patients. Most common TRs included febrile nonhemolytic TRs (FNHTRs) and allergic reactions. Reactions were more frequent in patients with a previous history of transfusion or those receiving more than one transfusion and in children, when transfusion was initiated after 30 min of issue of blood component. Majority of reactions were managed with symptomatic treatment, were nonserious, moderately severe, probably preventable and probably associated with the suspect blood component in both populations.CONCLUSION:Transfusion reactions in children and surgical patients are commonly observed with cellular blood components. Majority of reactions are acute and nonserious. FNHTRs and allergic reactions are the most common transfusion reactions. Risk of transfusion reactions is more in patients receiving multiple transfusions.

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Section: Discussionmentioning

confidence: 50%

Section: Discussionmentioning

confidence: 94%

Section: Discussionmentioning

confidence: 99%

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Transfusion-related adverse reactions in pediatric and surgical patients at a tertiary care teaching hospital in India

Ghataliya

Kapadia

Desai

et al. 2017

Asian J Transfus Sci

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“…Adequate knowledge with regard to ATRs and its various patterns of presentation will guide for prompt identification with subsequent management and appropriate measures to prevent ATR in future as well. 1 6 Hemovigilance being a quality indicator of transfusion medicine, functions as a continuous system of data collection for analysis of transfusion-related adverse reactions. 6 7 It provides a platform to investigate their underlying etiopathogenesis and clinical outcomes and prevent their occurrence as well as recurrence in long term.…”

Section: Introductionmentioning

confidence: 99%

“…1 6 Hemovigilance being a quality indicator of transfusion medicine, functions as a continuous system of data collection for analysis of transfusion-related adverse reactions. 6 7 It provides a platform to investigate their underlying etiopathogenesis and clinical outcomes and prevent their occurrence as well as recurrence in long term. 7 8 Thus hemovigilance process is directed with a purpose to ensure safety and efficacy of blood transfusion procedure covering the sequential chain of donors to recipients.…”

Section: Introductionmentioning

confidence: 99%

Analysis of Patterns of Adverse Transfusion Reactions and Management: A Novel Initiative toward Hemovigilance in a Teaching Hospital of South India

et al. 2020

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Objective Blood transfusion being a major lifesaving frontline procedure in majority of clinical wards, has a high potential with risk for adverse events ranging in severity, thus warranting optimal usage of blood. Continuous monitoring of adverse transfusion reaction (ATR) and analysis of the reactions can promote better comprehension of various contributing risk factors. Hemovigilance being a quality indicator with data system assists in ensuring quality and safe blood transfusion. The present study was designed to analyze the incidence and nature of adverse transfusion-associated events reported to the blood bank from our teaching hospital located in the remote part of South-East Coastal region with emphasis on corrective and preventive actions. Materials and Methods The prospective study included all the ATR reported to our hospital blood bank over a period of 42 months. The transfusion reactions report forms filled by the clinicians were analyzed and the reactions were categorized into patterns. The associated risk factors for the reaction are evaluated with substantial laboratory and clinical parameters in reference to hemovigilance. Results Among 19,800 transfusions, 189 transfusion reactions were encountered with a ratio of 10:0.9 with age ranging from 12 to 80, with female preponderance. Reactions associated with whole blood (WB) transfusion were common (50%, p = 0.002) followed by packed red blood cells transfusion (PRBC) (1.4%, p = 0.006) and platelets (0.8%, p = 0.1). Febrile nonhemolytic transfusion reactions were predominant patterns noted in 122 cases followed by allergic reactions in 43 cases with more commonly associated PRBC transfusion whereas hemolytic reactions showed association with WB transfusion. No delayed reactions or mortalities were encountered. Conclusion The present study concludes with novelty showing the overall incidence of transfusion-associated reactions in the study domain is slightly higher than more advanced centers in India owing to lack of leukodepletion units which could enable to substantially retard the incidence of adverse events of transfusion as a general measure and febrile reactions in particular. Hemovigilance and pattern analysis of ATR provide scope for corrective and preventive action and give referral guidelines to prevent future recurrence.

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Incidence and Analysis of 7 Years Adverse Transfusion Reaction: A Retrospective Analysis

Saha

Krishna

Prasath

et al. 2019

Indian J Hematol Blood Transfus

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Safe blood transfusion is the primary need of all the health care delivery system. Though with the advances of transfusion medicine, the incidences of transfusion risk is gradually reduced, but the adverse transfusion reaction (ATR) of non hemolytic type still prevails. The purpose of this study was to estimate the incidence and pattern of transfusion-related adverse events at our centre. The present retrospective observational study was conducted in the Department of Transfusion Medicine from April 2011 to April 2018, at a multi-organ transplant centre in South India. All the Adverse transfusion reactions were investigated in detail in the blood bank for the clerical errors, immunohematology workup and classified according to their nature with imputability assessment. A total of 140 ATR were reported out of 100,569 blood components distributed during the study period. After the analysis and workup of the reported reactions, majority of the reactions were observed in males (71%, n = 99). Most common symptom presented was Itching/Rashes in 43.6% (n = 61) ATR. Allergic reactions (51.4%, n = 72), were the most commonly encountered ATR followed by FNHTR (25.7%, n = 36). FFP transfusions (0.2%) contributed to the majority of the reactions followed by Red cell transfusion (0.15%). ATR were observed maximum in Hepato-biliary disease and liver transplantation patients (62%) followed by oncology patients (15%). The overall incidence of ATR in our study is 0.14% which is comparatively low compared to other studies due to well established hemovigilance systems. Adoption of more equipped methods & sensitive technology in various areas of blood banking will help to bring down the unwanted adverse transfusion reactions.

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Study of acute transfusion reactions in a teaching hospital of Sikkim: A hemovigilance initiative

Cited by 20 publications

References 17 publications

Transfusion-related adverse reactions in pediatric and surgical patients at a tertiary care teaching hospital in India

Transfusion-related adverse reactions in pediatric and surgical patients at a tertiary care teaching hospital in India

Analysis of Patterns of Adverse Transfusion Reactions and Management: A Novel Initiative toward Hemovigilance in a Teaching Hospital of South India

Incidence and Analysis of 7 Years Adverse Transfusion Reaction: A Retrospective Analysis

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