Study of Adrenocortical Physiology in Normal and Schizophrenic Men

Abstract

In this study the urinary excretion rates of urinary water, total 17-ketosteroids, creatinine, inorganic phosphates, sodium, potassium, uric acid, and corticoids (neutral reducing lipids) were measured ; in addition, in the blood, the lymphocyte and eosinophile count and the sugar content were determined. Methods used in these determinations are cited in references to

Studies of brain dysfunction in schizophrenia.

“…Hoskins (46) suggests that in schizophrenia the adrenal-autonomic mechanism is somehow disturbed, probably ultimately expressing itself in altered metabolism. Work on the adrenals and the emergency functions has been followed up by Hoagland and others (17,39,40,41,42). These studies are typical of the many reported.…”

The Serum Urate Level Reflects Degree of Stress

“…The relationship of uric acid to schizophrenia is obscure. Hoagland, et al, 22 first found the excretion of uric acid to be significantly higher in schizophrenics in the 40-60 age group. The younger age group, 20-30 years, did not show any difference from th e control group.…”

Effect of Electric Convulsive Therapy and Insulin Shock Therapy on the Pituitary Gonadotropin Production of Psychotic Patients*

“…The aim was to evaluate the acute changes caused by ECT itself. (2) Series of [10][11] ECTs were performed on two male schizophrenic patients; one, aged 32, with acute recurrence of hallucinations and other symptoms and another, aged 27, in the deteriorated stage of disease. Gonadotropin outputs were examined as often as necessary before, during, and after the treatment periods.…”