2016
DOI: 10.1016/j.ijbiomac.2015.12.028
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Study of an injectable in situ forming gel for sustained-release of Ivermectin in vitro and in vivo

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Cited by 16 publications
(15 citation statements)
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“…Thus, show a slow in vitro release rate with a burst release of 10.46% and 80% where the cumulative release is within 80 days. As for pharmacokinetic results show the concentration of effective blood on the gel can be maintained up to 110 to 120% (Geng et al, 2016).…”
Section: Saib-pla Combination Gel Forming Agent Formulationmentioning
confidence: 97%
See 1 more Smart Citation
“…Thus, show a slow in vitro release rate with a burst release of 10.46% and 80% where the cumulative release is within 80 days. As for pharmacokinetic results show the concentration of effective blood on the gel can be maintained up to 110 to 120% (Geng et al, 2016).…”
Section: Saib-pla Combination Gel Forming Agent Formulationmentioning
confidence: 97%
“…The use of in situ gel-forming using gum gel can be used for drugs for vaginal use purposes, wherein research conducted by Patel, and Patel in 2015, obtained test results from gum gellan formulations combined with the active substance clindamycin, showing improved texture characteristic results seen from rheological results. The addition of HPMC to the formulation is useful to reduce the sole at the gel transition temperature, as well as also used to affect the mucoadhesive Formulations can be used (Geng et al, 2016) ( Kurniawansyah et al, 2018).…”
Section: Gel Forming Agent Formulation Gel Combination Gellan Gummentioning
confidence: 99%
“…The solution to these problems focussed on two aspects. One is shrinking the gelation time after administration, such as increasing the gelator concentration, modifying gelator structure or adding crosslinker [24][25][26]. The other is preloaded the drug into some vesicles such as microemulsions, nanoparticles or microspheres [27,28].…”
Section: Introductionmentioning
confidence: 99%
“…Significant advantages of the SABER system are a reduction in the amount of organic solvent, ease of use, lower production costs, and excellent sustained-release behavior that can be adjusted by additives from a few days to several months (Okumu et al., 2002 ). The most commonly used additives are biocompatible polymers, such as polylactic acid (PLA) and poly(d,l-lactide-co-glycolide) (PLGA) (Lu et al., 2008 ; Lin et al., 2012 ; Geng et al., 2016 ). However, there are few reports about the application of SABER systems in long-lasting delivery of bioactive polysaccharides.…”
Section: Introductionmentioning
confidence: 99%