Study of Aneurysmal Subarachnoid Hemorrhage in Izumo City, Japan

Abstract

The incidence rate of subarachnoid hemorrhage is much higher than that reported so far in the literature, and despite improvement of management and surgical therapy, the actual case-fatality rate is still high, mainly because of the high mortality rate directly associated with the primary bleeding.

Genome-wide association study to identify genetic variants present in Japanese patients harboring intracranial aneurysms

“…As the rupture of an IA leads to subarachnoid hemorrhage (SAH), which often results in death or severe physical disability, the disease is considered to be a major public health concern. [1][2][3] Much of the etiology of IA still remains unknown, but subjects with a family history of IA have a higher risk of being affected by IA, suggesting that some genetic components contribute to predisposition to developing an IA. Previously, we conducted a genome-wide linkage study in affected Japanese sib pairs 4 and showed through subsequent association studies that the single nucleotide polymorphisms (SNPs) of ELN and LIMK1 on chromosome 7 was significantly associated with IA.…”

The Incidence of Aneurysmal Subarachnoid Hemorrhage in Youngdong District, Korea

“…Since the era of the computed tomography, the lower incidences were reported in England, France, and USA ranging from 2 to 10 annual incidences per 100,000 populations 3,6,11) . However, higher results exceeding 20 annual incidence per 100,000 populations were reported in some published studies from Japan and Finland 9,10,12,14,18,20,25) . The estimated incidence can be influenced by the age and size of population studied, difference on diagnostic accuracy, criteria adopted to define the aneurysmal SAH, type of study, and methodology for collecting data.…”

“…The incidence of aneurysmal SAH has ranged widely among reports from different regions of the world and at different points in time 3,[5][6][7][9][10][11][12]14,18,20,25) . Since the era of the computed tomography, the lower incidences were reported in England, France, and USA ranging from 2 to 10 annual incidences per 100,000 populations 3,6,11) .…”

Incidence rate of Aneurysmal SAH in Gwangju City and Jeollanamdo Province in 2007

“…There have been many studies on the incidence of aneurysmal subarachnoid hemorrhage(SAH) with widely varying annual incidences 2,3,6,[8][9][10][11][12] . The overall incidence of SAH was approximately 10 to 11 cases per 100,000 persons per year but varies significantly by region, with doubled rates in Japan and Finland and far lower rates in South and Central America 3,[8][9][10][11] .…”

“…The overall incidence of SAH was approximately 10 to 11 cases per 100,000 persons per year but varies significantly by region, with doubled rates in Japan and Finland and far lower rates in South and Central America 3,[8][9][10][11] . The reported incidence of SAH depends on the various factors : the nature of population 8,10) , the quality of diagnostic techniques, the size of the population, the diagnostic criteria, the age distribution of the population, the sophistication of data collection and analysis and factors that may increase the likelihood of occurrence of the disease 3,14) .…”