Study of Anthropometric Measurements, Biochemical Parameters and Hormonal Levels in Women With Pcos at a Tertiary Center of Rural Haryana

Abstract

BACKGROUND During the past decade, our understanding of pathophysiology of PCOS has undergone a remarkable evolution. Despite our familiarity with this disease, some of its fundamental characteristics remains poorly recognized and understood. The present study focuses on comprehensive knowledge about the current and emerging concepts of the PCOS such as, pathogenesis, diagnosis and better management of the syndrome. Obesity was found to be one of the important factors that contribute to the development of long-term risk of PCOS. In addition, increased obesity and abdominal adiposity further aggravate the clinical, hormonal and metabolic parameters in PCOS and, if treated, can reverse most of these abnormalities to a clinically significant degree. Our study suggests that anthropometric parameters (especially BMI & WHR) are significantly correlated with lipid profile in PCOS patients confirming the importance of early treatment of obesity to prevent further complications in the future. We wanted to study the anthropometric measurements, the hormonal status and biochemical parameters in females diagnosed with PCOS, study the correlation between them, and compare them with controls. METHODS In this prospective case control study, women clinically diagnosed with PCOS (N=100) and age matched healthy control female subjects (N=100) in the age group (18-35) years were enrolled. Body mass index (BMI), waist to hip ratio (WHR), fasting blood glucose, lipid profile and hormonal levels were estimated in both groups and further compared using student t-test. Anthropometric measurements were also correlated with the hormonal levels & biochemical parameters and the results were analysed using Pearson's correlation coefficients. Sample size was taken for convenience. RESULTS We found that the levels of TSH, LH, FSH, LH/FSH ratio, prolactin, TC, TG, LDL & TC/HDL ratio were significantly raised in PCOS females as compared to healthy females (p < 0.0001). Anthropometric measurements (BMI, waist-to-hip ratio) showed significant positive correlation with TSH, biochemical parameters (TC, TG, LDL & TC/HDL ratio) and hormonal profile (LH, FSH, LH/FSH ratio & Prolactin) of PCOS women. CONCLUSIONS There is significant derangement in hormonal & biochemical status of women suffering from PCOS that leads to an altered energy metabolism and endocrinological cascade of PCOS. Also, the anthropometric measurements were statistically significantly different from controls which showed significant positive correlation with the hormonal and biochemical parameters. This emphasizes the importance of early treatment of obesity, timely identification of hypothyroidism and biochemical derangement to prevent complications in the future. Awareness, Prevention, and Treatment, of PCOS at an early stage should be actively taken up for a healthy woman and a healthy nation.

Cardiovascular Risk Predictors High Sensitivity C-Reactive Protein and Plasminogen Activator Inhibitor-1 in Women with Lean Phenotype of Polycystic Ovarian Syndrome: A Prospective Case-Control Study

“…Studies suggest that women with PCOS exhibit features of the metabolic syndrome, especially dyslipidemia which is found in majority of cases. [25][26][27][28] In 2012, Xia et al proposed that LAP was a powerful index for detection of insulin resistance in nondiabetic individuals. 29 In 2009, Wiltgen et al suggested a positive association of LAP with Homeostatic Model Assessment of Insulin Resistance (HOMA) index in PCOS and postulated that it can accurately assess insulin resistance in PCOS women.…”