Study of anti ulcer activity of sodium metavanadate on alcohol and pylorus ligation induced gastric ulcers in rats

Suthar, PB; Jain, Shailesh; Mehta, A. M.; Santani, DD

doi:10.4103/0250-474x.34563

Cited by 3 publications

(3 citation statements)

References 15 publications

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“…Suther et al found a similar protective effect when they studied sodium metavanadate alone, in contradistinction to the present study, where a combination of selenium and vanadiun sulphate was investigated 6 . Suther et al postulated that the protective role of vanadium was mediated by suppressing aggressive factors such as gastric acid secretion and enhanced mucin activity 6 .…”

Section: Discussionsupporting

confidence: 54%

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The Protective Effect of Vanadium Sulphate on Ethanol-Induced Gastric Ulcer

Kemeir¹,

El-Hassan²

2013

BMB

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Design: Experimental animals study. Method: Except for the control group (group I), gastric ulcer was induced in five groups of rats (II to VI), each consists of six. Ethanol was fed into rats which were pre-treated with distilled water, cimetidine, vanadium, selenium and a combination of vanadium and selenium (group II to VI respectively). The ulcer indices were determined in all these groups. Following macroscopic observations, specimens of the stomachs were taken and processed for histologic examination. Stomachs were then homogenized separately for each group and the supernatants were assayed for the activities of superoxide dismutase (SOD), catalase (CAT), levels of reduced glutathione (GSH) and thiobarbituric acid reactive substances (TBARS). Levels of these compounds from all groups were statistically analyzed for comparison. Result: Rats pre-treated with the reference drug cimetidine showed more or less normal gastric mucosa. However, mild disruption of the surface mucosa was observed in rats receiving selenium and vanadium. Those receiving combination of selenium and vanadium showed almost normal mucosa. Furthermore, vanadium alone or in combination with selenium demonstrated a significant reduction of tissue lipid peroxidation levels, and potent ameliorative effect of the enzymatic and non-enzymatic components of the endogenous antioxidant systems. Conclusion: Vanadium sulphate significantly inhibits lipid peroxidation and enhances the effects of enzymes that scavenge free radicals that are implicated in the pathogenesis of ethanol-induced ulcers in rats. Selenium seems to enhance its action and exerts a synergistic effect.

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Section: Discussionsupporting

confidence: 54%

“…In a short communication by Suther et al, the effect of sodium metavanadate was studied in ethanol and pylorus ligation induced ulcer models in rats 6 . The complex has shown a significant reduction in the total acid output and a rise in carbohydrates and mucin; thus, the authors concluded that sodium metavanadate possessed a significant antiulcer effect.…”

mentioning

confidence: 99%

The Protective Effect of Vanadium Sulphate on Ethanol-Induced Gastric Ulcer

Kemeir¹,

El-Hassan²

2013

BMB

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“…Pyloric ligation leads to an increase in gastric volume due to the accumulation of gastric acid in the stomach 30 . After administration of both doses of SFMA leaves, gastric volume was significantly decreased.…”

Section: Discussionmentioning

confidence: 99%

Untitled

2023

IJPSR

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A peptic ulcer is an excoriated area of the stomach or intestinal mucosa caused principally by the digestive action of gastric juice or small upper intestinal secretions. A peptic ulcer is a conglomerate of heterogeneous disorders that manifests as a lesion in the lining of the gastrointestinal mucosa bathed by acid and pepsin. Peptic ulcers frequently occur along the lesser curvature of the antral end of the stomach or, more rarely, in the lower end of the esophagus, where stomach juices frequently reflux. It occurs because of an imbalance between aggressive factors (gastric acid and pepsin) and defensive factors (gastric mucus, bicarbonate, prostaglandins). The white mulberry tree (M. alba L.) is a deciduous tree originating from Asia but currently cultivated in subtropical, tropical, and moderate environments. M. alba leaves contain triterpenoid and steroidal saponin (lupeol, β-Sitosterol), bioflavonoids (rutin, moracetin, quercetin-3triglucoside and isoquercitrin), coumarins, volatile oil, alkaloids, amino acids and organic acids, rutin, quercetin. M. alba leaves have various pharmacological properties such as anti-cancer, Anti-dopaminergic, and Hepatoprotective activity. Antimicrobial activity, antioxidant activity. Due to the presence of several phytoconstituents in this plant have been used for ages in various traditional medicine systems to treat cough, tonify blood, constipation and diabetes.

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