Study of Antibacterial Efficacy of Methanolic and Aqueous Leaf Extracts of Scoparia dulcis on Some Human Pathogenic Bacteria

Jose, Sophy; Sinha, Manoranjan

doi:10.20546/ijcmas.2017.601.051

Cited by 2 publications

(2 citation statements)

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“…From the earliest time it has been well known that India has a uent oral biodiversity and it has abounded the herbal medicine practitioners with a very helpful collection of 'natural pharmacy' which has become a pool and reservoir for selection of plants as ingredients in the extraction and preparation of herbal medicines for the effective treatment, control and management of a great many number of human diseases [1]. The World Health Organization (WHO) has de ned medicinal plants as-plant which in one or more of its organs contains substances that can be used for curative purposes, or which are predecessors of useful drugs is called as medicinal plants [2].…”

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confidence: 99%

Hormonal profile and haematological parameters of Wistar albino rats treated with methanolic and aqueous leaf extracts of Schleichera oleosa

Jose

Sinha

2021

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Background: The present study aims to study the Hormonal profile and haematological parameters of Wistar albino rats treated with methanolic and aqueous extracts of Schleichera oleosa.Result: The amount of RBC was found to be 9.6±0.057106/mm3, 9.7±0.0125, 106/ 9.5±0.003, 106/mm3 9.5±0.012 106/mm3 and 9.5±0.023 106/mm3. The amount of WBC was found to be 13.5±0.058 103/mm3,13.6±0.0113 103/mm3,13.7±0.021 103/mm3, 9.5±0.012 103/mm3 and 9.5±0.023 103/mm3. Platelets, 396±0.577 103/mm3, 395±0.03 103/mm3 , 397±0.042103/mm3 , 398±0.020103/mm3, and 397±0.011103/mm3 for controlled group, low dose of methanolic extract, high dose of methanolic extract, low dose of aqueous extract and high dose of aqueous extract respectively. The packed cell volume, haemoglobin, mean corpuscular volume, mean corpuscular haemoglobin, corpuscular haemoglobin concentration and amount of neutrophils, Eosinophils, Lymphocytes, Basophils and Monocytes were measured and no significant change was noticed. The amount of testosterone showed significant increase from 0.75± 0.024 pg/ mL (control) 2.96± 0.088 pg/ mL, 3.9± 0.14pg / mL, 1.85± 0.076 pg/ mL and 2.85± 0.074 pg/ mL.Conclusions: The study suggests that the prolonged treatment of Wistar rats with both low dose and high dose of methanolic as well as the aqueous extract of Schleichera oleosa is not toxic and they increased the amount of testosterone in the blood which is indicative of their testosterone enhancement.

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confidence: 99%

Hormonal profile and haematological parameters of Wistar albino rats treated with methanolic and aqueous leaf extracts of Schleichera oleosa

Jose

Sinha

2021

Preprint

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“…5 Genus Schleichera is belonging to the soapberry family Sapindaceae and is generally found in Indian subcontinent and in mixed deciduous forests and in Southeast Asia. 6 Schleichera oleosa has been used in traditional medicine and its leaf, seed, oil and bark are used for curing itch, burns, acne pain etc., and it promotes hair growth, treats rheumatism, head ache, skin diseases, malarial fever and is prophylactic against cholera. 7 Screening of proximate phytochemicals and in vitro antihypertensive activity of the leaf extracts of S. oleosa has not been explored previously.…”

Section: Introductionmentioning

confidence: 99%

Anti-hypertensive activity of aqueous and methanolic leaf extracts of Schleichera oleosa (Lour.) Merr

Dandapat¹,

Jose²,

Sinha³

2019

JAPLR

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Nitric oxide radical scavenging activityNOSA was performed as per previous method of Kumar et al.,11 10μg, 50μg and 100μg concentrations of aqueous and methanolic plant extract and Butylated hydroxy anisole (BHA) were taken in different test tubes and made up to 3ml with 0.1M phosphate buffer J Anal Pharm Res. 2019;8(3):94-97. 94 AbstractPresent study was undertaken to investigate phytochemical, nitric oxide scavenging activity and antihypertensive activity of the methanolic and aqueous leaf extracts of S. oleosa. The phytochemical analysis carried out revealed the presence of flavanoids, glycosides, alkaloids, tannins, saponins and steroids and many other metabolites. Both the extracts showed high NOSA (33.81% and 31.43% NOSA at 100µg concentration). The methanolic leaf extract showed 1.6%, 4%, and 5.6% ACE inhibition against 10µg, 50µg and 100µg concentration respectively and aqueous leaf extract of S. oleosa showed very negligible percentage that is 0%, 0% and 0.8% ACE inhibition against 10µg, 50µg and 100µg extract concentration respectively while Captopril showed 100% ACE inhibition against all the three concentrations. The result shows that the methanolic as well as the aqueous leaf extracts of Schleichera oleosa are not very good antihypertensive agents. However the methanolic leaf extract of Schleichera oleosa is a better antihypertensive inhibitor than the aqueous leaf extract.

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Study of Antibacterial Efficacy of Methanolic and Aqueous Leaf Extracts of Scoparia dulcis on Some Human Pathogenic Bacteria

Cited by 2 publications

References 7 publications

Hormonal profile and haematological parameters of Wistar albino rats treated with methanolic and aqueous leaf extracts of Schleichera oleosa

Hormonal profile and haematological parameters of Wistar albino rats treated with methanolic and aqueous leaf extracts of Schleichera oleosa

Anti-hypertensive activity of aqueous and methanolic leaf extracts of Schleichera oleosa (Lour.) Merr

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