Study of antidepressant drugs in GPR39 (zinc receptor−/−) knockout mice, showing no effect of conventional antidepressants, but effectiveness of NMDA antagonists

Młyniec, Katarzyna; Gaweł, Magdalena; Nowak, Gabriel

doi:10.1016/j.bbr.2015.03.053

Cited by 32 publications

(26 citation statements)

References 24 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Moreover, GPR39 receptors have also been reported to play a role in the action of antidepressants. GPR39 knockout mice have been shown to be resistant to the normalizing effects of imipramine and escitalopram in the forced swim test (FST) [ 53 ]. Moreover, studies have shown that the binding of zinc to GPR39 receptors activates downstream cyclic AMP-response element (CRE)-dependent gene transcription, resulting in higher levels of brain-derived neurotrophic factor (BDNF) in the hippocampus and cortex [ 54 ].…”

Section: Zincmentioning

confidence: 99%

Zinc, Magnesium, Selenium and Depression: A Review of the Evidence, Potential Mechanisms and Implications

et al. 2018

View full text Add to dashboard Cite

Micronutrient deficiency and depression are major global health problems. Here, we first review recent empirical evidence of the association between several micronutrients—zinc, magnesium, selenium—and depression. We then present potential mechanisms of action and discuss the clinical implications for each micronutrient. Collectively, empirical evidence most strongly supports a positive association between zinc deficiency and the risk of depression and an inverse association between zinc supplementation and depressive symptoms. Less evidence is available regarding the relationship between magnesium and selenium deficiency and depression, and studies have been inconclusive. Potential mechanisms of action involve the HPA axis, glutamate homeostasis and inflammatory pathways. Findings support the importance of adequate consumption of micronutrients in the promotion of mental health, and the most common dietary sources for zinc and other micronutrients are provided. Future research is needed to prospectively investigate the association between micronutrient levels and depression as well as the safety and efficacy of micronutrient supplementation as an adjunct treatment for depression.

show abstract

Section: Zincmentioning

confidence: 99%

Zinc, Magnesium, Selenium and Depression: A Review of the Evidence, Potential Mechanisms and Implications

et al. 2018

View full text Add to dashboard Cite

show abstract

“…Another way that zinc may interact with the serotonergic system is via the previously mentioned GPR39 receptor. In GPR39 knockout mice, only NMDA antagonists, but not monoamine-based antidepressants, have antidepressant effect, thus establishing a connection between zinc, serotonin, and BDNF expression (Młyniec et al, 2015). This research further alludes to serotonin and zinc's interaction.…”

Section: Glutamatergic Hyperactivity and Zinc Dysregulation In Depresmentioning

confidence: 99%

The Emerging Role for Zinc in Depression and Psychosis

et al. 2017

View full text Add to dashboard Cite

Zinc participation is essential for all physiological systems, including neural functioning, where it participates in a myriad of cellular processes. Converging clinical, molecular, and genetic discoveries illuminate key roles for zinc homeostasis in association with clinical depression and psychosis which are not yet well appreciated at the clinical interface. Intracellular deficiency may arise from low circulating zinc levels due to dietary insufficiency, or impaired absorption from aging or medical conditions, including alcoholism. A host of medications commonly administered to psychiatric patients, including anticonvulsants, oral medications for diabetes, hormones, antacids, anti-inflammatories and others also impact zinc absorption. Furthermore, inefficient genetic variants in zinc transporter molecules that transport the ion across cellular membranes impede its action even when circulating zinc concentrations is in the normal range. Well powered clinical studies have shown beneficial effects of supplemental zinc in depression and it important to pursue research using zinc as a potential therapeutic option for psychosis as well. Meta-analyses support the adjunctive use of zinc in major depression and a single study now supports zinc for psychotic symptoms. This manuscript reviews the biochemistry and bench top evidence on putative molecular mechanisms of zinc as a psychiatric treatment.

show abstract

“…Várias evidências sugerem a importância desse receptor para a depressão. Em animais que não possuem o receptor GPR39 no cérebro, além de apresentarem um comportamento tipo-depressivo 118,122 , o efeito da administração de alguns antidepressivos como a imipramina, reboxetina e escitalopram não ocorre, sugerindo que o receptor do zinco é importante para a ação de antidepressivos que agem no sistema monoaminérgico 123 . Além disso, esses animais sem GPR39 possuem níveis menores de CREB e BDNF no hipocampo 118 .…”

Section: Estudos Pré-clínicos Associando Zinco E Depressãounclassified

O papel do zinco no transtorno depressivo maior

Manosso¹

2019

Rev Bras Nutr Func

View full text Add to dashboard Cite

Major depressive disorder is one of the most disabling diseases, and the prevalence of this disorder is increasing in the population. Although the treatment of depression is safe, it is far from ideal, with a large number of non-responses and/or side effects. In this way, strategies that can improve the treatment of mood disorders are necessary. Among these strategies, several studies are investigating the role of zinc. Thus, the aim of this paper is to review the main clinical and preclinical data that correlate zinc with depression, and the possible mechanisms of action of this mineral.

show abstract

Study of antidepressant drugs in GPR39 (zinc receptor−/−) knockout mice, showing no effect of conventional antidepressants, but effectiveness of NMDA antagonists

Cited by 32 publications

References 24 publications

Zinc, Magnesium, Selenium and Depression: A Review of the Evidence, Potential Mechanisms and Implications

Zinc, Magnesium, Selenium and Depression: A Review of the Evidence, Potential Mechanisms and Implications

The Emerging Role for Zinc in Depression and Psychosis

O papel do zinco no transtorno depressivo maior

Contact Info

Product

Resources

About