Study of antimicrobial activity of iodine coordination complexes against multidrug resistant bacteria

Jumagaziyeva, Ardak B.; Kenesheva, Sabina T.; Bakytov, D. B.; Berdibay, S. B.; Paretskaya, N. А.; Dathayev, U. M.; Karpenyuk, Tatyana A.; Tamazyan, R. А.; Ilin, Aleksandr I.

doi:10.26577/eb-2018-1-1322

Cited by 1 publication

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“…Despite increase in the number of new antibacterial drugs on the market, the emergence of antibiotic resistance is currently a global medical and social problem [1]. In this regard, the development and creation of fundamentally new antimicrobial drugs for the treatment of infectious diseases caused by multiply resistant microorganisms is an urgent problem.…”

Section: Introductionmentioning

confidence: 99%

Study of the distribution of the coordinating compound C11H12N2O2•(C11H13N2O2)+•NA+•2Н2О•(I4)2- in mice organism by radioisotope method

Turganbay

Sabitov

Liu

et al. 2021

IJBCh

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The paper presents the results of studies on the effect of a new synthesized coordination compound based on an amino acid-tryptophan and iodine compounds on bacterial DNA and the kinetics of its distribution in mice tissues after a single intravenous or oral administration. A radiochemical study of the quantitative content of the coordination compound labeled with iodine-131 in the system of laboratory mice after intravenous and oral administration showed the presence of an isotopic label in the tissues and organs under study. The coordination compound has the ability to accumulate in internal organs and tissues in various concentrations with a further decrease by 24 hrs (study period) and clearance of the drug from the body. The effect of a solution of a coordination compound labeled with the 131 I isotope on the E. coli culture ATCC 25922 showed that DNA halogenation occurs due to the breakdown of the tryptophan-tetraiodide iodine complex in the cell with the formation of molecular iodine.

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Section: Introductionmentioning

confidence: 99%