Study of arsenic exposure in oral/oropharyngeal carcinoma in West Bengal

Abstract

Objectives:To study any possible correlation between arsenic toxicity and the development of oral carcinoma in West Bengal population. Material and Methods: Ethical clearance for this study was obtained from the Vivekananda Institute of Medical Sciences. Out of 30 785 patients attending our hospital from November 2012 to July 2015, 107 cases and 50 control individuals were selected. The hair and buccal smear samples were obtained upon their consent for the purpose of the analysis of arsenic count and cytogenetic damage, respectively. Results: Ninety-six percent of cases came from the highly arsenic affected districts and 81.3% showed their arsenic count above the safe limit (0.8 μg/g) whereas 96% of the controls' arsenic count was within the safe limit. The study showed a significant difference of the micronuclei and apoptosis frequency between the cases and controls. Conclusions: The difference of micronuclei and apoptosis frequency between cases and controls was significant. The maximum number of cases came from highly arsenic affected areas and a higher percentage of cases showed elevated arsenic count, as compared to controls, which may indicate a possible link between arsenic toxicity and this disease. However, a larger sample size is required for a proper correlation. Int J Occup Med Environ Health 2017;30(2):271-279

Is There any Effect of Addictions in Arsenic Induced Oral Carcinoma?

“…However, its effect in oral carcinoma is not well studied. A few studies in Taiwan, Pakistan and India have indicated its positive correlation with the occurrence of this carcinoma (Su et al, 2010, Arain et al, 2015, Pal et al, 2017, 2018. Since West Bengal is the most affected state in India, we have chosen this metal toxicity as a possible cofactor or an independent risk factor in the oral carcinoma.…”

“…These two areas are the worst affected areas in the world (Ratnaike, 2003). It has also been reported that arsenic toxicity may lead to the occurrence of oral carcinoma in various places (Su et al, 2010, Arain et al, 2015, Pal et al, 2017, 2018 apart from skin, lung and bladder carcinoma. So, our aim of this study is to find out whether the effect of addictions or the metal toxicity through drinking water intake is acting as the most potent factor in the development of oral carcinoma and correlate these three; selecting the population of West Bengal, India.…”

Der Tumormarker Sialinsäure

“…Aus arbeitsmedizinischer Sicht gelten UV-Strahlung, Schwefeldioxid, Asbest, Arsen Pestizide, Aerosole von starken anorganischen Säuren und brennendem Erdöl als Risikofaktoren, die zur Entstehung von Mundhöhlenkarzinomen beitragen können [8,47]. Die Exposition gegenüber Gummiprodukten, Metall-und Holzstäuben kann die Entwicklung eines Speicheldrüsenkarzinoms begünstigen [8,48,49].…”

Evaluation of salivary protein patterns among a rural population exposed and non-exposed to arsenic-contaminated drinking water in areas of Tucumán (Argentina): a pilot study

“…Despite the well-documented effect of arsenic exposure in the development of skin, lung and bladder cancer, evidence of a relationship with OC is scarce. [6][7][8] OC presents precursor lesions that are not considered neoplasms, although they are related to a higher probability of developing into OSCC, known as potentially malignant lesions (PML). Those are: oral submucous fibrosis, erythroplakia, leukoplakia, chronic candidiasis, congenital dyskeratosis, lichen planus and actinic cheilitis.…”