Background: Globally, chronic obstructive pulmonary disease (COPD) has a substantial and growing burden. Thus, among rural adults in Delhi National Capital Region (Delhi NCR), the study examines the prevalence of COPD among nonsmokers and the relationship between biomass fuel (BMF) use and COPD. Materials and methods: This cross-sectional study, conducted among adults in rural Delhi NCR areas with or without COPD, was community based. Enrolment comprised 1,564 individuals from 561 households. Information was gathered using a standard questionnaire, indoor particulate matter (PM) (PM1, PM2.5, and PM10) aerosol spectrometers were used to measure the concentrations, and pulmonary function tests (PFTs) were performed using a portable spirometry (GRIMM). Results: In adults in rural areas of Delhi NCR, 8.95% prevalence of COPD were found in which females were found significantly high COPD as compared with males (7.1% males and 92.9% females, p < 0.001).