Study of Association Between Maternal 25 – hydroxy Vitamin D3 Level and Neonatal Outcome

Rajoria, Nupur; Gupta, MC; Rajoria, Lata; Rajoria, Narain Bihari

doi:10.21276/sjams.2016.4.7.60

Cited by 4 publications

(9 citation statements)

References 22 publications

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“…They concluded that maternal vitamin D status did not significantly affect neonatal anthropometry. Similar interpretation was made by Maghbooli et al 12 No major correlation was found amongst vitamin D concentration in cord blood and concentration of maternal vitamin D and the newborns' characteristics (length, head circumference, weight, diameter of anterior fontanel, diameter of posterior fontanel and APGAR score) and low birth weight. 15 In contrast to the above observations, Bowyer et al observed that subjects with deficient vitamin D had a decreased birth weight in newborns.…”

Section: Maghbooli Et Al Reported An Inverse Relationship Betweensupporting

confidence: 87%

“…The mean age was found to be 24 years. 12 In the present study, the mean maternal ALP (r= -0.5503, Chi square=88.38, p=0.000) was significantly higher (114.30±15.59) in vitamin D deficient patients (p<0.05) with a weak negative correlation. As depicted in Table 4, maternal serum calcium bears a positive correlation with vitamin D levels which is statistically significant (r=0.7486, Chi square=137.53, p=0.000).…”

Section: Discussionsupporting

confidence: 42%

“…Rajoria et al similarly reported that 86% of women in their study conducted in SMS Medical College Jaipur from June 2014 to April 2015, were deficient, 12.4% insufficient and only 1.6% had sufficient vitamin D levels. 12 Sahu et al observed a higher incidence of decreased vitamin D in expectant subjects (74%) from rural Indian community in a study conducted in Barabanki, Lucknow. 13 In the present study, subjects' mean age was reported to be 25.75 ± 3.36 years.…”

Section: Discussionmentioning

confidence: 96%

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Effect of hypovitaminosis D and its related factors in pregnant women and their newborns

Sandhu¹,

Nautiyal²,

Mehrotra³

et al. 2019

Int J Reprod Contracept Obstet Gynecol

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Background: Maternal and fetal vitamin D deficiency has nowadays emerged as a frequent morbidity. Adequate vitamin D concentrations during pregnancy are necessary to maintain neonatal calcium homeostasis, bone maturation and mineralization. Objectives of this study were to evaluate serum vitamin D concentration in mothers and its correlation with neonatal cord blood vitamin D at the time of delivery and to study the impact of hypovitaminosis on neonatal anthropometry. Effect of related factors like calcium (Ca), alkaline phosphatase (ALP) and parathyroid hormone (PTH) on maternal vitamin D levels were to be evaluated. Methods: Cross sectional study was done on a total of 220 healthy uncomplicated antenatal females with singleton pregnancy attending labor room at the time of delivery. Maternal and neonatal cord blood samples were drawn in the delivery room and analyzed. Neonatal anthropometry was recorded. Correlations among various maternal and neonatal factors were studied. Results: Widespread vitamin D deficiency was observed in expectant subjects and neonates with 70.91% having deficient levels which were also reflected in newborns (71.82%). Maternal ALP (r= -0.5503, p=0.000) bears a weak negative correlation (p<0.05), maternal serum Ca positive correlation (r = 0.7486, p=0.000) and plasma PTH levels a negative correlation (r = -2.084, p=0.000) with hypovitaminosis. No significant correlation was observed between neonatal anthropometry and vitamin D levels. Conclusions: High prevalence of hypovitaminosis was observed among pregnant women and their neonates in this study. A positive linear relationship was seen between maternal and cord blood vitamin D (r 0.974, p 0.0001).

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Section: Maghbooli Et Al Reported An Inverse Relationship Betweensupporting

confidence: 87%

Section: Discussionsupporting

confidence: 42%

Section: Discussionmentioning

confidence: 96%

See 1 more Smart Citation

Effect of hypovitaminosis D and its related factors in pregnant women and their newborns

Sandhu¹,

Nautiyal²,

Mehrotra³

et al. 2019

Int J Reprod Contracept Obstet Gynecol

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“…The increasing use of multivitamins and mineral dietary supplements in younger to older adults does not appear to be associated with a corresponding increase in VD concentrations [36] and clinical guidelines suggest that doses of VD more than 600 IU/day may be needed to maintain adequate plasma levels, but the appropriate standard is still debated [37]. In some randomized controlled studies, loading doses as high as 1000e4000 IU/day were needed before adequate VD plasma concentrations were measured [38].…”

Section: Discussionmentioning

confidence: 99%

Association of vitamin D in pregnancy and after 15 days of delivery along with neonatal

Mehrotra

Sandhu

Nautiyal

2019

Clinical Nutrition Experimental

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Background &aims: India, where sunshine is abundant throughout the year, the extent of VD deficiency have been reported ranging from 50% to 86.5% for neonatal and young infants, which is still huge. The high prevalence of VD deficiency during pregnancy is increasingly recognized, especially in women, following customs like a veil. Uttarakhand located at the foothills of Himalayas is the totally socio-culturally diverse state with higher population density in the plain region like Dehradun, India. Methods: To understand the differences in VD status we evaluated 25 (OH) D levels in three trimesters of pregnancy and at birth in neonatal serum and cord blood along with 15 days of life born within our hospital along with mother respectively. Results: The study demonstrated a high prevalence of VD levels at the time of pregnancy. The studied reflects a deficiency of serum VD in the first trimester 18 ± 6 ng/ml, while in second and third trimester VD levels were more 38 ± 3 and 41 ± 4 ng/ml respectively as compared to first. There was a significant difference in VD status due to the presence of supplementation in both cord blood and in neonatal serum. There are many traditional factors which contributed to the observation of the high occurrence of VD deficiency in this study. Identifying VD deficiency at pregnancy time and after birth should be essential for the growth of public policy for anticipation and supplementation. Conclusions: The study demonstrated a high prevalence of VD status with significant differences due to the existence of supplementation. There are many traditional factors which contributed to the observation of the high occurrence of VD deficiency in this study. Identifying VD deficiency at pregnancy time and after birth

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“…This improved bioavailability ensures that a greater proportion of the drug reaches the target site, enhancing therapeutic effectiveness. [ 5 ]…”

Section: Emerging Of In Situ Gelsmentioning

confidence: 99%

Exploring the Transformative Potential of In Situ Gels: An Overview of Thermosensitive and pH‐Sensitive Gel Systems for Biomedical Applications

Patil,

Chougule

et al. 2024

Macromolecular Symposia

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In situ gel systems have emerged as promising drug delivery platforms due to their numerous benefits, including increased patient compliance and decreased administration frequency. The potential of in situ gel extends beyond its formulation benefits, with the ability to transform medical treatment by enhancing drug delivery, offering personalized therapies, and introducing innovative approaches. Ongoing research and the efforts of pharmaceutical companies are dedicated to exploring the vast opportunities presented by in situ gel, pushing the limits of innovation in the field of drug delivery. The selection of suitable polymers is critical for the development of in situ gel formulations. Additionally, consideration of drug‐polymer compatibility ensures the stability and efficacy of the drug within the gel matrix. Formulation considerations play a pivotal role in the development of effective in situ gel systems. They have shown great potential in drug delivery systems, tissue engineering, and regenerative medicine. The ability to prolong gastric retention time, targeted delivery, and localized drug release are among the advantages offered by in situ gels. Although in situ gel technology has shown significant advancements, challenges remain, including stability and shelf‐life issues, biocompatibility and safety concerns, and the need for further research and development. Future directions focus on overcoming these challenges and exploring new applications and advancements in the field. In conclusion, in situ gel systems provide a versatile and promising drug delivery and tissue engineering platform. However, further research and development are essential to address the challenges and fully harness the potential of this innovative technology.

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Study of Association Between Maternal 25 – hydroxy Vitamin D3 Level and Neonatal Outcome

Cited by 4 publications

References 22 publications

Effect of hypovitaminosis D and its related factors in pregnant women and their newborns

Effect of hypovitaminosis D and its related factors in pregnant women and their newborns

Association of vitamin D in pregnancy and after 15 days of delivery along with neonatal

Exploring the Transformative Potential of In Situ Gels: An Overview of Thermosensitive and pH‐Sensitive Gel Systems for Biomedical Applications

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