Study of associationship between gall stone composition and bacteriological spectrum in chronic calculous cholecystitis

Abstract

Background: Chronic calculous cholecystitis is the benign disease affecting the gallbladder, frequently female population of middle age. This study was done with the objective of study the composition of gall stones, microbiological spectrum and their association in chronic calculous cholecystitis patients.Methods: This is a prospective study done on 131 cases of chronic calculous cholecystitis admitted in the department of General Surgery (DNB), K.K. Hospital, Lucknow for cholecystectomy during January 2018 to January 2019. 31 patients were excluded from the study based on exclusion criteria. USG of abdomen was done in all 100 cases. All patients underwent either open cholecystectomy (OC) or laparoscopic cholecystectomy (LC).During cholecystectomy bile was aspirated and was sent to laboratory for culture. Gallstone retrieved from the specimen and was classified based on morphology.Results: Out of 100 cases, 76 cases underwent LC and 24 cases were done with OC. Female dominance was seen in the study (69%). The predominant type of gall stone in present study was cholesterol (68%). The bile culture test was positive in 20% of cases. The most common isolated microorganism was E. coli (50%). No significant association was observed between composition/type of gall stone and isolated microorganisms in bile (p=0.126).Conclusions: The result concluded that chronic calculous cholecystitis was more common in females of middle age group. Bile culture was positive in 20% cases and E. coli was the common organism isolated. Identification of the type of organism is crucial for early management of the disease condition.

Etiology and chemical composition of gall stone disease: a prospective observational study from the developing world

“…16 Singh et al in their study had 69% females and 31% males. 14 In our study, 30 (30%) patients were smokers. Protective effects of cigarette smoke on the pathogenesis of GS and absence of such relationship, identified in some previous studies indicate controversial role of effect of smoking on GS formation.…”

“…Our findings are in concordance with those of Gupta AM et al and Singh KK et al, wherein the age of the patients varied from 21-73 years, and the mean age ranged from 43 years to 46 years, respectively. 13,14 In our study, majority of patients were females 74 (74%) and 26 (26%) were males, with a female to male ratio of 2.8:1. Similar results were observed by Weerakoon et al in their study of 102 patients.…”

“…68% had normal BMI and BMI of 25-29.9 kg/m 2 was seen in 17% of patients of their study population. 14 In a large prospective cohort study by Liu et al, increase in BMI was significantly associated with higher risks of gallstone disease. 22 Underlying comorbidities were seen in 46 (46%) patients in our study among which 17 (17%) patients had hypertension and diabetes mellitus, 12 (12%) patients had hypertension and 9 (9%) patients had hypothyroidism.…”