Study of Bacteria Isolated from Orthopedic Implant Infections and their Antimicrobial Susceptibility Pattern

Khosravi, Azar Dokht; Ahmadi, Fatemeh; Salmanzadeh, Shokrolah; Dashtbozorg, A.; Montazeri, Effat Abbasi

doi:10.3923/jm.2009.158.163

Cited by 42 publications

(55 citation statements)

References 13 publications

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“…This strongly supports an intra operative contamination and we assumed that these were the main nosocomial pathogens in the operating room. The present findings were in agreement with those of a study which was done by Khosravi et al, [9] which reported that S. aureus as the most prevalent isolate, followed by Klesiella ozaenae and P. aeruginosa among the gram negative bacilli. Though the infections which are caused by fungi and mycobacteria are rare [1], we reported the first case till date in the literature of C. krusei PJI.…”

Section: Resultssupporting

confidence: 94%

“…Though the infections which are caused by fungi and mycobacteria are rare [1], we reported the first case till date in the literature of C. krusei PJI. No anaerobes were isolated, though anaerobes play a significant role in the pathogenesis of PJI occurring at >24 months following implant insertions, especially when there is an extra medullary internal fixation device [9]. However, none of the patients in the present study presented with PJI after 18 months.…”

Section: Resultscontrasting

confidence: 51%

“…Gomez et al, [7] reported only 60% culture positivity. Zimmerli et al, [8] and Khosravi et al, [9] published positive culture rates of 89% and 93.9% respectively. We noticed an 84% culture positivity from three samples which we collected in our study.…”

Section: Resultsmentioning

confidence: 99%

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The Microbiological Profiles of Infected Prosthetic Implants with an Emphasis on the Organisms which Form Biofilms

Fernandes¹

2013

JCDR

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Background: In spite of the decreasing incidence of orthopaedic device related infections to 1%, nowadays, device-related infections still remain a diagnostic, therapeutic and cost -related problem. Aims and Objective:To record the common causative organisms and the contributing risk factors for orthopaedic device-related infections in a tertiary care teaching hospital. Methods:In a prospective study, fifty patients who underwent orthopaedic device implantation from Jan 2009 -June 2010 were enrolled; among them, 42 patients were complicated with infections. The demography, microbiological data, treatment and the outcome of each patient were recorded. Statistical Analysis:The data was analyzed in terms of frequency and percentage.Results: Of the 50 samples, 42(84%) were culture positive, while 8(16%) were cultures negative. The femur was the most commonly affected bone in both males (median age-37.1yrs) and females (median age-41.3 yrs). Staphylococcus aureus was the organism which was most commonly isolated and which caused biofilms, followed by non-fermenting, gram negative bacilli and Klebsiella spp. We reported the first case till date in the literature of Candida krusei PJI, to the best of our knowledge. No anaerobes were isolated. Tissue trauma, open fractures, post-operative surgical site infections and Diabetes mellitus were found to be the important risk factors. The biofilm forming organisms were commonly associated with polymicrobial infections and even an aggressive antibiotic therapy was often inadequate to eliminate the infections. A conservative surgical treatment was associated with treatment failures. Implant removal or replacement was required in most of the cases to eradicate the infection. Conclusion:The most common bacteria which were isolated included Staphylococcus aureus, followed by Pseudomonas aeruginosa and Klebsiella. A majority of them are resistant to the commonly used antibiotics, leading to treatment failures which necessitated an implant removal. InTROduCTIOnA prosthetic replacement and an implant surgery is commonplace in orthopaedic operations for successfully alleviating the pain and improving the mobility in damaged joints.

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Section: Resultssupporting

confidence: 94%

Section: Resultscontrasting

confidence: 51%

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The Microbiological Profiles of Infected Prosthetic Implants with an Emphasis on the Organisms which Form Biofilms

Fernandes¹

2013

JCDR

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“…The prevalence of wound infection was not significantly affected by age (p>0.05) ( Table 1). Similar findings were obtained in the study of Khosravi et al [15], in Pakistan, the median age was 35 (± 15.8) years. Similarly, Ranjan et al [16], in a referral hospital in Haryana, India found the modal age group as 21-40 years with the frequency of 146.…”

Section: Age-wise Distribution Of Samplessupporting

confidence: 80%

Surgical Site infections: Distribution Studies of Sample, Outcome and Antimicrobial Susceptibility Testing

Bastola¹,

Parajuli²,

Neupane³

et al. 2017

J Med Microb Diagn

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Background: The present study was conducted in the clinical lab of Microbiology department, College of Medical Sciences. The samples that were sent for culture and sensitivity from patients developing signs and symptoms collected from patients developing symptoms of SSIs in different wards as well as ICUs of this hospital were included in this study. A total of 206 pus samples were processed and result was interpreted on the basis of different tests. Isolation and identification of the organism was done by gram stains and culture growth. Antibiotic susceptibility test was performed by Kirby Bauer disc diffusion method and result was interpreted as per Clinical and Laboratory Standards Institute (CLSI) guidelines.

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“…In long-term hospitalisation of bedridden patients with poor perianal care, gram negative contamination has been shown to be greater (74.7%) [10]. Khosravi et al determined mostly Staphylococcus aureus (21%) in orthopaedic implant infections, but overall, gram negative bacteria were isolated at a high rate of 66% [11]. The lower rate of gram positive bacteria determined in the current study can be thought to be due to insufficient postoperative care and patient compliance.…”

Section: Discussionmentioning

confidence: 41%

Overview of Implant Infections in Orthopaedics Department: Retrospective Study

Bulut¹,

Tahta²,

Akgün³

et al. 2016

Ann Clin Anal Med

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Study of Bacteria Isolated from Orthopedic Implant Infections and their Antimicrobial Susceptibility Pattern

Cited by 42 publications

References 13 publications

The Microbiological Profiles of Infected Prosthetic Implants with an Emphasis on the Organisms which Form Biofilms

The Microbiological Profiles of Infected Prosthetic Implants with an Emphasis on the Organisms which Form Biofilms

Surgical Site infections: Distribution Studies of Sample, Outcome and Antimicrobial Susceptibility Testing

Overview of Implant Infections in Orthopaedics Department: Retrospective Study

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