Study of Bactericidal and Bacteriostatic Antibiotics in Animals with Normal and Suppressed Immunity

Biró, László Péter; Iván, E

doi:10.1159/000220536

Cited by 7 publications

(2 citation statements)

References 2 publications

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“…In certain diseases (e.g., endocarditis), both animal models and clinical experience favor bactericidal agents [16][17][18][19][20][21][22][23][24][25]. Other studies suggest that combinations of bactericidal and bacteriostatic agents may lead to improved clinical outcomes, compared with either type of agent alone [23,26,27].…”

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The Importance of Bactericidal Drugs: Future Directions in Infectious Disease

Finberg

Moellering

Tally

et al. 2004

Clinical Infectious Diseases

184

114

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The bulk of the evidence supports the concept that, in treating endocarditis and meningitis, it is important to use antibacterial agents with in vitro bactericidal activity. This conclusion is based on both human and animal data. The data to support bactericidal drugs' superiority to bacteriostatic drugs do not exist for most other clinical situations, and animal models do not support this concept in some situations. Clinicians should be aware that drugs that are bacteriostatic for one organism may in fact be bactericidal for another organism or another strain of the same organism.

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mentioning

confidence: 99%

The Importance of Bactericidal Drugs: Future Directions in Infectious Disease

Finberg

Moellering

Tally

et al. 2004

Clinical Infectious Diseases

184

114

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“…In cases of staphylococcus infections, the bactericidal antibiotics proved more effec tive than the bacteriostats. We employed immunosuppressive procedures in the above experiment, and found that when the resistance capacity of the animals was reduced, the difference in the effectiveness of the 2 drugs became more marked [4]. In the course of our experiments we wished to study the change of the defensive mechanism in mice, in con sequence of diabetes mellitus or advanced age against Staphylococcus aureus infection.…”

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confidence: 99%

Study of Bactericidal and Bacteriostatic Antibiotics in Experimentally Diabetic and Senescent Mice, in Cases of Lethal Staphylococcal Infection

Biró¹,

Iván²

1971

Chemotherapy

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With model experiments we endeavoured to further clinical experience in that infection of patients in a state of immunodepression may be treated more efficiently with bactericidal than with bacteriostatic antibiotic drugs. In cases of lethal infection due to Staphylococcus aureus, we studied the behaviour of animals with intact or immunosuppressed immune systems under bactericidal and bacteriostatic antibiotic therapy. As index we used the mortality rate and the possibility of reculturing the infectious strain. In our experiments we studied the effect of diabetes mellitus and senescence as influencing factors on the course of infection. It was indicated that in diabetic model experiments the effect of bactericidal antibiotic drugs was more advantageous, both in reduced mortality and lower possibility of reculture.

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Antimicrobial Therapy in Ruminants

Larson

1975

Veterinary Clinics of North America

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Study of Bactericidal and Bacteriostatic Antibiotics in Animals with Normal and Suppressed Immunity

Cited by 7 publications

References 2 publications

The Importance of Bactericidal Drugs: Future Directions in Infectious Disease

The Importance of Bactericidal Drugs: Future Directions in Infectious Disease

Study of Bactericidal and Bacteriostatic Antibiotics in Experimentally Diabetic and Senescent Mice, in Cases of Lethal Staphylococcal Infection

Antimicrobial Therapy in Ruminants

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