Study of bipathic effect of phenazepam

Epstein, O. I.; Воронина, Т. А.; Молодавкин, Г. М.; Belopolskaya, M. V.; Kheyfets, I. A.; Dugina, J. L.; Сергеева, С. А.

doi:10.1007/s10517-007-0371-9

Cited by 8 publications

(5 citation statements)

References 5 publications

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“…Further studies confirmed this phenomenon. It was shown that modulating action of RAD of phenazepam significantly potentiated anxiolytic and anticonvulsant effects of therapeutic doses of phenazepam in Vogel conflict test and in rats with corazol-induced seizures, both after prior or simultaneous administration [16]. Combination of RAD of haloperidol and therapeutic doses of haloperidol significantly increased psychotropic neuroleptic effect of conventional doses of the drug administered preliminarily or simultaneously [17].…”

Section: Introductionmentioning

confidence: 99%

RETRACTED ARTICLE: Release-Active Dilutions of Diclofenac Enhance Anti-inflammatory Effect of Diclofenac in Carrageenan-Induced Rat Paw Edema Model

Sakat

Mani

Demidchenko³

et al. 2013

Inflammation

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The study was aimed to investigate the effect of technologically treated diclofenac (release-active dilutions of diclofenac (RAD of diclofenac)) on anti-inflammatory activity of diclofenac in carrageenan-induced rat paw edema model. Ninety male Wistar albino rats (6–8 weeks) divided into nine groups (n = 10) were used. Anti-inflammatory activity was assessed at 1, 2, 3, 4, and 6 h after subplantar injection of carrageenan (0.1 ml of a 1 % solution in normal saline). Diclofenac alone was studied at 5 and 20 mg/kg, RAD of diclofenac alone at 7.5 ml/kg and their combination at 5 and 7.5 ml/kg, respectively. Diclofenac reduced (p < 0.05 at least) paw edema at all time points. RAD of diclofenac enhanced (p < 0.05) anti-inflammatory effect of diclofenac (5 mg/kg) at 2, 4, and 6 h on concurrent and at 2 and 4 h on sequential administration. Moreover at 2 h, anti-inflammatory effect of combination treatment reached values comparable to those of diclofenac (20 mg/kg). In conclusion, RAD of diclofenac enhanced anti-inflammatory effect of diclofenac.

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Section: Introductionmentioning

confidence: 99%

RETRACTED ARTICLE: Release-Active Dilutions of Diclofenac Enhance Anti-inflammatory Effect of Diclofenac in Carrageenan-Induced Rat Paw Edema Model

Sakat

Mani

Demidchenko³

et al. 2013

Inflammation

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“…The anxiolytic effect of phenazepam is observed with the introduction of low doses of phenazepam (10 −10 mol/kg) [ 27 , 28 ], but in our experiment, the level of anxiety in rats (at a dose of phenazepam of 1 mg/kg) remained unchanged. What could be the reason for such a dose-dependent effect?…”

Section: Discussioncontrasting

confidence: 54%

Color-Coding Method Reveals Enhancement of Stereotypic Locomotion by Phenazepam in Rat Open Field Test

et al. 2023

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One of the most important tasks in neuroscience is the search for theoretical foundations for the development of methods for diagnosing and treating neurological pathology, and for assessing the effect of pharmacological drugs on the nervous system. Specific behavioral changes associated with exposure to systemic influences have been invisible to the human eye for a long time. A similar pattern of changes is characteristic of phenazepam, a drug with a wide range of effects on the brain. In this study, we used a color-coding method, which consists of combining three time positions in one image, the present (0 s), the near future (0.33 s) and the far future (1.6 s). This method made it possible to identify movement patterns, such as the initialization of ahead movements, side turns and 180° turns (back), and also to determine the degree of predictability of future movements. The obtained data revealed a decrease in the number of turns to the sides while maintaining ahead movement, as well as an increase in the predictability of movements in rats under the influence of phenazepam. Thus, sedative doses of phenazepam do not exhibit general depression of brain functions, but the inhibition of specific centers, including the medial prefrontal cortex and postsubiculum, which are involved in stereotypic locomotive behavior.

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“…In a series of experiments, animals were co-administered a "high" (either a therapeutic or even toxic) dose of a common drug, such as prednisolone, haloperidol, phenazepam, diclofenac or cyclophosphamide, together with a "high dilution" of the same drug. The results showed that in the presence of its "high dilution", the activity of the drug was positively modified, enhancing pharmacological effects and reducing toxicity [37][38][39][40][41][42][43][44][45][46][47][48].…”

Section: "High Dilutions" Of Substancesmentioning

confidence: 99%

The Spatial Homeostasis Hypothesis

Epstein¹

2018

Symmetry

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From studies on the effects of "high dilutions" on organisms, it was found that their administration induces a delicate physiological (molecular and cellular) response. Occasionally, physiological reactions can become atypical (pathological) individual reactions. To resolve this paradox, the spatial homeostasis hypothesis has been proposed. It considers pathological processes as tools used by living systems, in order to retain their spatial integrity (symmetry), allowing them to properly reflect the geometry of the surrounding world and thus, to be a part of the evolutionary process. This article addresses an interdisciplinary subject and is aimed at natural scientists (physicists, chemists, and biologists) as well as philosophers.

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Study of bipathic effect of phenazepam

Cited by 8 publications

References 5 publications

RETRACTED ARTICLE: Release-Active Dilutions of Diclofenac Enhance Anti-inflammatory Effect of Diclofenac in Carrageenan-Induced Rat Paw Edema Model

RETRACTED ARTICLE: Release-Active Dilutions of Diclofenac Enhance Anti-inflammatory Effect of Diclofenac in Carrageenan-Induced Rat Paw Edema Model

Color-Coding Method Reveals Enhancement of Stereotypic Locomotion by Phenazepam in Rat Open Field Test

The Spatial Homeostasis Hypothesis

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