Study of bone mineral density in lumbar spine and femoral neck in a Spanish population

Curiel, Manuel Dı́az; Pena, João Luiz; Pérez, José Luis Coca; Cano, R. Pérez; Rapado, A; Martinez, I Ruiz

doi:10.1007/bf01623462

Cited by 149 publications

(60 citation statements)

References 12 publications

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“…BMD expressed as the number of standard deviations below the peak BMD of young women, were estimated using the values of Caucasian women in the third National Health and Nutrition Examination Survey (NHANES) study as reference (12). T-scores at the lumbar spine were estimated using a Spanish population database as reference (13). Verbal informed consent was obtained from participants.…”

Section: Subjectsmentioning

confidence: 99%

A common polymorphism in the 5'-untranslated region of the aromatase gene influences bone mass and fracture risk

Zarrabeitia

Hernández

Valero

et al. 2004

European Journal of Endocrinology

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Objective: The aromatization of androgenic precursors in peripheral tissues, including bone, is the main source of estrogens after the menopause. CYP19, the gene encoding aromatase, has a long 5 0 -untranslated region with several variants of exon I and specific promoters. The aim of this study was to investigate the possible relationship between a common biallelic (C/G) polymorphism located on exon I.2 and bone mineral density (BMD). Design: This was designed to be an association study between CYP19 polymorphism and BMD and the risk of vertebral fractures in women. Methods: DNA was extracted from the peripheral blood of 299 women (116 premenopausal and 183 postmenopausal). CYP19 alleles were identified by a method based on the exonuclease activity of Taq-polymerase. BMD was determined by dual-energy absorptiometry. Results: In premenopausal women there were no genotype-related differences in BMD. However, postmenopausal women with the CC genotype had lower spine and hip BMD than those with the GG genotype. The association between CYP19 genotypes and BMD was independent of other variables, such as age, height, body weight, calcium intake or years since menopause. The CC genotype was also associated with an increased risk of osteoporotic vertebral fractures (odds ratio 2.0; P ¼ 0.03). Serum levels of estrone and estradiol were similar in women with CC and GG alleles. Conclusions: A common biallelic polymorphism in the 5 0 -untranslated region of the CYP19-aromatase gene was associated with significant differences in bone mass and the risk of vertebral fractures in postmenopausal women. Given the frequency of allelic variants, genotype-related differences appear to be important from the perspective of the individual as well as the general population. Further studies are needed to elucidate underlying mechanisms that may be dependent on differences in estrogen bioactivity at the bone tissue level.European Journal of Endocrinology 150 699-704

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Section: Subjectsmentioning

confidence: 99%

A common polymorphism in the 5'-untranslated region of the aromatase gene influences bone mass and fracture risk

Zarrabeitia

Hernández

Valero

et al. 2004

European Journal of Endocrinology

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“…We calculated the Z-score and T-score according to the Spanish population databases [35,36,37]. For the norms of patient classifications, whether osteopenic or osteoporotic, we used internationally accepted definitions [38].…”

Section: Methodsmentioning

confidence: 99%

Bone Disease Induced by Phenytoin Therapy: Clinical and Experimental Study

et al. 2009

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Previous studies have made references to prolonged treatment with phenytoin as a possible risk factor in the development of osteoporosis and/or osteomalacia. We studied a group of 30 epileptic patients who were under long-term treatment with phenytoin (DPH) in an ambulatory regimen. We found the prevalence of osteoporosis to be 3.3% and of osteopenia to be 56.6%, affecting predominantly the femur, without any significant decrease in bone mineral density of the lumbar spine. These patients were showing signs of bone turnover uncoupling with increases in bone resorption markers. At this time, they also exhibited slight alterations in their phosphocalcium metabolism with trends to hypocalcemia and secondary hyperparathyroidism that was found not to be caused by a vitamin D deficiency as the serum levels of 25(OH)D and 1,25(OH)₂D were normal. With the aims of corroborating these results and to investigate the physiopathological effects on the bone induced by anticonvulsant drugs we developed a further experimental study in which we administered DPH over a 6-week period with a dose of 5 g/kg/day to male Wistar rats that were in the growth phase. This treatment produced a decrease in overall BMD and bone mineral content in the femur. We did not find osteomalacia in the vertebral biopsy, but the administration of DPH to these animals decreased trabecular volume as well as lessened the thickness of osteoid edges together with an uncoupling in bone turnover. There was also a marked decrease in bone formation and a tendency towards increased bone resorption. We have also found a decrease in resistance to fracture by torsion in the biomechanical assay, which translates into an increase in bone fragility. In these male Wistar rats, the administration of DPH produced a tendency towards increasing the markers of resorption and, though changes in serum levels of calcium and phosphorus were not observed, to provoke an increase in the parathyroid hormone levels; with normal levels of 1,25(OH)₂D which has produced the same inclination in rats as in humans.

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“…A study published by Hye Won 16 , carried out in patients with the same characteristics as ours (acute phase CVA), found rates of osteopenia and osteoporosis in the spine of 39% and 43% respectively, although we should remember that, according to studies carried out by Díez Curiel, the reduction of BMD is more common in the spine than in the hip 23 . It may appear surprising that the control group, despite being similar in sex and age to the patients with CVA, have a greater risk of suffering a major osteoporotic or hip fracture, a situation which may be correlated with a greater number of fragility fractures in the 10 years prior to the study.…”

Section: Discussionmentioning

confidence: 47%

Riesgo de fractura osteoporótica mayor y de cadera en pacientes con accidente cerebrovascular en fase aguda: estudio prospectivo multicéntrico

Olmo

Román

León

et al. 2014

Rev Osteoporos Metab Miner

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40 SummaryObjetives: Hemiplegic patients are considered to be a population at risk of suffering osteoporotic fractures. The aim of this work is to understand the absolute risk of fragility fracture in patients with cerebrovascular accident (CVA) and the osteometabolic state of patients with ictus in the acute phase, as well as confirming if there are baseline differences compared to a control group without cerebrovascular pathology. Patients and method: Multicentre prospective study carried out in five Spanish hospitals. Two groups were established: a) patients with ictus of less than three months development, and b) a control group from a population without cerebrovascular disease. History of fragility fractures, number of falls in the previous year, bone mineral density (BMD) in the hip, FRAX ® index, determinations of biochemistry and bone markers -calcium, phosphorus, alkaline phosphatase, vitamin D, parathormone (PTH), and carboxy-terminal telopeptide of collagen type I (CTX) -were analysed. Results: A total of 82 patients were studied: 50 patients with CVA and 32 controls. 12% of those patients with CVA had an increased risk of suffering a hip fracture, and 8% an increased risk of a major osteoporotic fracture. In the control group the risk was greater. The hemiplegic patients had BMD in the hip lower than those in the control group, although the differences in both variables were not statistically significant. The levels of CTX were higher in patients with CVA, this being the sole determination which showed a statistical difference between the two groups studied. Conclusions: The patients with CVA had values of markers for bone resorption (CTX) significantly higher and a BMD in the hip lower than those in the control group.

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Study of bone mineral density in lumbar spine and femoral neck in a Spanish population

Cited by 149 publications

References 12 publications

A common polymorphism in the 5'-untranslated region of the aromatase gene influences bone mass and fracture risk

A common polymorphism in the 5'-untranslated region of the aromatase gene influences bone mass and fracture risk

Bone Disease Induced by Phenytoin Therapy: Clinical and Experimental Study

Riesgo de fractura osteoporótica mayor y de cadera en pacientes con accidente cerebrovascular en fase aguda: estudio prospectivo multicéntrico

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