Study of bronchoalveolar lavage in HIV-infected children

Sias, Selma Maria de Azevedo; Nunes, Raquel Coronato; Cabral, Livia Maria Maia Nunes; Oliveira, Renata Mendonça de; Rocha, Tamires dos Santos; Cardoso, Claudete Aparecida Araújo

doi:10.1016/j.bjid.2012.08.028

Cited by 2 publications

(2 citation statements)

References 4 publications

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“…Примерно у 25 % детей, перенесших трансплантацию гемопоэтических стволовых клеток (ТГСК), развивается поражение легочной ткани [3,4]. Недавние исследования показали, что проведение бронхоскопии с бронхоальвеолярным лаважом (БАЛ) у иммунокомпрометированных детей способствует выявлению патогенных микроорганизмов в 28-68 % случаев и способствует назначению этиотропной антибактериальной терапии [5][6][7][8][9][10][11][12].…”

Section: актуальностьunclassified

“…Поражение легочной ткани инфекционной этиологии при острых лейкозах (чаще миелоидных) у детей встречается в 27,7-40,4 % случаев и сопровождается летальным исходом в 8,9 % случаев [1,2]. При поражении легочной ткани на фоне аплазии кроветворения в постхи-миотерапевтическом периоде показано проведение бронхоскопии с целью определения генеза выявленных при инструментальном обследовании изменений.Примерно у 25 % детей, перенесших трансплантацию гемопоэтических стволовых клеток (ТГСК), развивается поражение легочной ткани [3,4]. Недавние исследования показали, что проведение бронхоскопии с бронхоальвеолярным лаважом (БАЛ) у иммунокомпрометированных детей способствует выявлению патогенных микроорганизмов в 28-68 % случаев и способствует назначению этиотропной антибактериальной терапии [5][6][7][8][9][10][11][12].…”

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Bronchoalveolar lavage in pediatric oncohematology

Krylovetskaya¹,

Gusarova²,

Savosin³

et al. 2023

Medicinskij alfavit

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Relevance. Pulmonary lesions of infectious etiology in oncohematological children are common and, in some cases, may be accompanied by a lethal outcome. When pulmonary tissue lesions on the background of hematopoiesis aplasia in the post-chemotherapy period is shown bronchoscopy to determine the genesis of the identified changes.Aim. To determine the diagnostic value of bronchoscopy with BAL in children with oncohematological diseases.Materials and methods. 25 bronchoscopies with BAL were performed on the basis of the endoscopic department of the Research Institute of Pediatric Oncology and Hematology.Results. According to the results of the study in 72% of cases a microbiologic agent was detected. The most frequent pathogens obtained by the results of cultures were Haemophilus parainfluenzae, Streptococcus oralis, Neisseria macacae, Streptococcus peroris and Pseudomonas aeruginosa.Conclusions. Bronchoscopy with BAL in children with blood system tumors is a highly informative method of pathogen detection and determination of the etiological cause of infiltrative-inflammatory changes in the lungs.

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Bronchoalveolar lavage in pediatric oncohematology

Krylovetskaya¹,

Gusarova²,

Savosin³

et al. 2023

Medicinskij alfavit

View full text Add to dashboard Cite

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Diagnostic Yield of Bronchoalveolar Lavage in Immunocompromised Children

Wong¹,

Hon²,

Leung³

et al. 2021

Journal of Tropical Pediatrics

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Results from early studies in the diagnostic yield of bronchoalveolar lavage (BAL) in immunocompromised adults and children were variable. This prospective study aimed to determine the diagnostic yield of BALs in immunocompromised children over the first 18 months of service at a newly established children’s hospital. Relationship between BAL results and changes in antimicrobial management was also studied. Twenty-one bronchoscopic BALs were performed on 18 children; 14 BALs (66.7%) yielded at least 1 pathogen and 7 (33.3%) yielded no pathogen. Two pathogens were found in 2 samples, and 1 pathogen was identified in 12 samples. Bacteria (n = 7 patients), viruses (n = 8 patients) and fungus (Pneumocycstis jirovecii in one patient) were yielded. Of the 21 BALs, 8 (38.1%) were associated with changes in antimicrobial management (Fisher’s exact test, p = 0.018). No significant side effects such as pneumothorax or pulmonary hemorrhages were observed in this series. In conclusion, BAL in immunocompromised children is rewarding and has potential to impact on antimicrobial management.

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Study of bronchoalveolar lavage in HIV-infected children

Cited by 2 publications

References 4 publications

Bronchoalveolar lavage in pediatric oncohematology

Bronchoalveolar lavage in pediatric oncohematology

Diagnostic Yield of Bronchoalveolar Lavage in Immunocompromised Children

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