Study of carbonyl iron/poly(butylcyanoacrylate) (core/shell) particles as anticancer drug delivery systems

Carboxylated core–shell particles: I. A system showing hindered swelling behavior

“…For example, polyelectrolyte brushes are used in the stabilization against flocculation of colloidal particles because of the electrosteric repulsive interaction, and recent studies show that have an excellent prospect for future nanotechnology [8]. Moreover, polyelectrolyte brushes are used as drug carriers [16,17], in controlled release applications, due to their ''smart" character (i.e. pH-sensitive particles).…”

Particle geometry, charge, and wettability

“…Some examples can be found in the literature, in particular considering vehicles with a composite structure consisting of a magnetic core and a biodegradable or biocompatible polymer. In the cases considered [47,48], the cores were iron or magnetite, leading to very different particle sizes (500 nm in the iron case [48], and 140 nm for magnetite cores [47]), but always with an external shell of poly(ethyl-2-cyanoacrylate). The results in Figure 21.2 constitute a proof of the similarities in specific (referred to the interfacial surface area) adsorption of the antitumour drug 5-fluorouracil (5-FU): note that, for the same external composition, the adsorption isotherms are roughly the same, as expected.…”

Crucial Functionalizations of Carbon Nanotubes for Improved Drug Delivery: A Valuable Option?

“…Heat induced apoptosis to tumor cells is the basis of successful application of metal nanoparticles in cancer therapy. Recently, a new method of reversible association of doxorubicin (DOX) or mitoxanthrone and other antineoplastic drugs to superparamagnetic iron oxide nanoparticles has been developed to improve magnetically targeted chemotherapy (32)(33)(34)(35)(36).…”