Study of changes in neuropsychological indicators in adults

Abstract

IntroductionCurrently, the number of cases of pathological aging of the CNS, represented by a violation of cognitive functions, is increasing. But there is a social request to prolong the physical and mental activity of older peopleObjectivesThe study of the dynamics of cognitive aging is timely and relevant. The article contains a report on a cohore non-repeating study of higher brain functions at various age periodsMethodsThe average age was 45.1 + 5.7 years. Inclusion criteria: 1. Dextral. Non-inclusion criteria: 1. Clinically significant somatic diseases in their medical history. 2. Mental disorders in their medical history. •Applied neuropsychological, statistical research methods. The research tool was the neuropsychological rapid method including the subtests: •“Memorizing 9 words in three presentations (1st, 2nd, 3rd attempts)”, •“Sequential subtraction”, •“Test of Benton’s visual memory”, •“Solving an arithmetic problem”, •“Overlaid images”, •“Specified flow of associations in 1 minute”, • “Figure of 3 geometric figures”, • “Blind hours”, • “Graph-motor test”, “Delay word reproduction”ResultsThe first cohort 27–40 years old. The second cohort 41–50 years old.Third cohort 51 years old and older. A significant difference in the performance of the graphomotor test between the subjects of the age subgroup of 27-40 years and the subgroup of 41-50 years was statistically confirmed. In older people revealed a much greater number of errors, interruptions of the test than the representatives of the more “young” subgroupConclusionsThe deterioration in the performance of the graphomotor test was the most age-specificDisclosureNo significant relationships.

Response strategies and biological applications of organic fluorescent thermometry: cell- and mitochondrion-level detection

“…Furthermore, electron-rich heteroatoms, such as nitrogen and oxygen, have been found could transform into unconventional luminophores when aggregated or clustered. 45 On this basis, De et al designed a uorescent temperature probe (10) based on electron-rich heteroatoms (O and N). 46 The combination of the temperature-driven aggregation behavior and AIE dyes enabled probe 10 to demonstrate a temperature response.…”

“…7 The obstruction of heat transfer by cytoplasmic and biological membranes results in a mitochondrial temperature different from cellular temperature. 8,9 In contrast, in diseased cells associated with mitochondrial dysfunction, the disruption of their energetic state 10 results in a disturbance in temperature homeostasis. For instance, individuals diagnosed with mitochondrial diseases oen exhibit a notable decrease in brain temperature due to impaired oxidative phosphorylation.…”