Study of chemical bonding, physical and biological effect of metformin drug as an organized medicine for diabetes patients with chromium(III) and vanadium(IV) ions

Adam, Abdel Majid A.; Sharshar, T.; Mohamed, Mahmoud A.; Ibrahim, Omar B.; Refat, Moamen S.

doi:10.1016/j.saa.2015.04.115

Cited by 17 publications

(5 citation statements)

References 43 publications

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“…In spite of this health risk, some recent reports point at possible application of selected chromium(III) complexes in medical therapy and diagnosis [9][10][11][12]. Very recent works on biological and medicinal aspects of chromium coordination chemistry include: (1) separation and speciation of chromium in chromium yeast [13], (2) syntheses, characteristics and biological activity of metforming drug for diabetes patients with chromium(III) [14] and (3) kinetic and mechanistic studies on Cr(V) ? Cr(III) transformations [15][16][17].…”

Section: Introductionmentioning

confidence: 99%

Hydrolytic and redox transformations of chromium(III) bis-oxalato complexes with glutaminic acid and glutamine: a kinetic, UV–Vis and EPR, study

Kiersikowska

Kita

et al. 2016

Transition Met Chem

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The title complexes have been synthesized, chromatographically isolated and characterized by their ligands to metal ratio determinations and spectroscopic analyses. The kinetics of the first aquation stage, i.e., the amino acid chelate ring opening via the Cr-N bond cleavage, has been studied spectrophotometrically in acidic and alkaline media. Hydrogen peroxide oxidizes the complexes in alkaline media to CrO 4 2-anion and a relatively stable Cr(V) complex. Consecutive biphasic kinetics through two first-order steps were observed for the base hydrolysis and the oxidation process, whereas the acidcatalyzed aquation obeys a simple first-order pattern. Based on the kinetic and spectroscopic data, mechanisms of the coordinated amino acid liberation and chromium(III) oxidation are discussed.

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Section: Introductionmentioning

confidence: 99%

Hydrolytic and redox transformations of chromium(III) bis-oxalato complexes with glutaminic acid and glutamine: a kinetic, UV–Vis and EPR, study

Kiersikowska

Kita

et al. 2016

Transition Met Chem

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“…In the examination and microstructural characterization of the Metformin drug and its antimicrobial complexes with V(VI) and Cr(III) ions, the PALS spectra revealed two lifetime components in the complexes attributed to their homogenous, crystalline structure. The relatively small differences between the spectral parameters of the complexes were caused by differences in the molecular weight and molar ratio of the metal ions [ 36 ]. The investigation of the structural characteristics of a series of N-heterocyclic compounds as organic solids was performed via PALS measurements.…”

Section: Resultsmentioning

confidence: 99%

Positron Annihilation Lifetime Spectroscopy as a Special Technique for the Solid-State Characterization of Pharmaceutical Excipients, Drug Delivery Systems, and Medical Devices—A Systematic Review

et al. 2023

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The aims of this systematic review are to explore the possibilities of using the positron annihilation lifetime spectroscopy (PALS) method in the pharmaceutical industry and to examine the application of PALS as a supportive, predictive method during the research process. In addition, the review aims to provide a comprehensive picture of additional medical and pharmaceutical uses, as the application of the PALS test method is limited and not widely known in this sector. We collected the scientific literature of the last 20 years (2002–2022) from several databases (PubMed, Embase, SciFinder-n, and Google Scholar) and evaluated the data gathered in relation to the combination of three directives, namely, the utilization of the PALS method, the testing of solid systems, and their application in the medical and pharmaceutical fields. The application of the PALS method is discussed based on three large groups: substances, drug delivery systems, and medical devices, starting with simpler systems and moving to more complex ones. The results are discussed based on the functionality of the PALS method, via microstructural analysis, the tracking of ageing and microstructural changes during stability testing, the examination of the effects of excipients and external factors, and defect characterization, with a strong emphasis on the benefits of this technique. The review highlights the wide range of possible applications of the PALS method as a non-invasive analytical tool for examining microstructures and monitoring changes; it can be effectively applied in many fields, alone or with complementary testing methods.

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“…2− anions acting as bridges (Scheme 8) [92]. The activity of complex 19 at concentration 1 mg/mL against various gram-positive and gram-negative bacterial strains, as well as fungal strains was investigated using a standard disk diffusion method in comparison with uncoordinated metformin (1 mg/mL), streptomycin (10 mg/mL) and ketoconazole (10 mg/mL).…”

Section: Group V (V Nb Ta)mentioning

confidence: 99%

“…Cr(III) complex 20 with three bidentate metformin ligands were obtained by the reaction of CrCl 3 •6H 2 O with 3 equiv. of metformin in a 72% yield (Scheme 9) [92]. Its activity was investigated against various bacterial and fungal strains under the same experimental conditions as complex 19.…”

Section: Group VI (Cr Mo W)mentioning

confidence: 99%

Biological Properties of Transition Metal Complexes with Metformin and Its Analogues

2022

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Metformin is a widely prescribed medication for the treatment and management of type 2 diabetes. It belongs to a class of biguanides, which are characterized by a wide range of diverse biological properties, including anticancer, antimicrobial, antimalarial, cardioprotective and other activities. It is known that biguanides serve as excellent N-donor bidentate ligands and readily form complexes with virtually all transition metals. Recent evidence suggests that the mechanism of action of metformin and its analogues is linked to their metal-binding properties. These findings prompted us to summarize the existing data on the synthetic strategies and biological properties of various metal complexes with metformin and its analogues. We demonstrated that coordination of biologically active biguanides to various metal centers often resulted in an improved pharmacological profile, including reduced drug resistance as well as a wider spectrum of activity. In addition, coordination to the redox-active metal centers, such as Au(III), allowed for various activatable strategies, leading to the selective activation of the prodrugs and reduced off-target toxicity.

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Study of chemical bonding, physical and biological effect of metformin drug as an organized medicine for diabetes patients with chromium(III) and vanadium(IV) ions

Cited by 17 publications

References 43 publications

Hydrolytic and redox transformations of chromium(III) bis-oxalato complexes with glutaminic acid and glutamine: a kinetic, UV–Vis and EPR, study

Hydrolytic and redox transformations of chromium(III) bis-oxalato complexes with glutaminic acid and glutamine: a kinetic, UV–Vis and EPR, study

Positron Annihilation Lifetime Spectroscopy as a Special Technique for the Solid-State Characterization of Pharmaceutical Excipients, Drug Delivery Systems, and Medical Devices—A Systematic Review

Biological Properties of Transition Metal Complexes with Metformin and Its Analogues

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