Study of chromatographic characteristics of inorganic analytes in biopartitioning micellar chromatography with ion‐pair additives

Rukhadze, M. D.; Lominadze, Nino; Akhalkatsi, Levan; Gvaramia, Manuchar

doi:10.1002/bmc.1446

Cited by 3 publications

(1 citation statement)

References 44 publications

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“…ILs can be used like ion-pair reagents due to the miscibility with water [63][64][65][66][67][68]. Imidazolium-based ILs have been used as mobile phase additives [67] and modifiers [68].…”

Section: Typical Structures Of Bonded-phase For Hilicmentioning

confidence: 99%

Fundamental Properties of Packing Materials for Liquid Chromatography

Hanai¹

2019

Separations

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The high performance of chemically-modified silica gel packing materials is based on the utilization of pure silica gels. Earlier silica gels used to be made from inorganic silica; however, nowadays, silica gels are made from organic silanes. The surface smoothness and lack of trace metals of new silica gels permits easy surface modifications (chemical reactions) and improves the reproducibility and stability. Sharpening peak symmetry is based on developing better surface modification methods (silylation). Typical examples can be found in the chromatography of amitriptyline for silanol testing and that of quinizarin for trace metal testing. These test compounds were selected and demonstrated sensitive results in the measurement of trace amounts of either silanol or trace metals. Here, we demonstrate the three-dimensional model chemical structures of bonded-phase silica gels with surface electron density for easy understanding of the molecular interaction sites with analytes. Furthermore, a quantitative explanation of hydrophilic and hydrophobic liquid chromatographies was provided. The synthesis methods of superficially porous silica gels and their modified products were introduced.

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“…ILs can be used like ion-pair reagents due to the miscibility with water [63][64][65][66][67][68]. Imidazolium-based ILs have been used as mobile phase additives [67] and modifiers [68].…”

Section: Typical Structures Of Bonded-phase For Hilicmentioning

confidence: 99%

Fundamental Properties of Packing Materials for Liquid Chromatography

Hanai¹

2019

Separations

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The use of polyoxyethylene (20) cetyl ether in assessing the hydrophobicity of compounds of biomedical importance and in the process of drug release from microemulsions

Lominadze,

Sebiskveradze,

Chaladze

et al. 2023

Tenside Surfactants Detergents

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The creation and study of artificial membranes based on microemulsions is an important direction due to the similarity of the structure of both direct and reverse microemulsions with cell membranes. A microemulsion mobile phase prepared with a non-ionic surfactant in combination with a C18 type stationary phase creates a similar image of the cell membrane in a chromatographic column. In addition, the use of microemulsion systems to transport drugs with low bioavailability into the body can increase their bioavailability. The chromatographic behaviour of model substances of biomedical importance was investigated using micellar mobile phases containing polyoxyethylene (20) cetyl ether in biopartitioning micellar chromatography (BMC) in the concentration range of 1–5 %. Cholic acid was introduced into the polyoxyethylene (20) cetyl ether micellar mobile phase to approximate the structure of the cell membrane. The hydrophobicity of the model compounds was evaluated. Hydrophobicity indices in the micellar mobile phase with and without addition of cholic acid were compared. The release profile of promethazine hydrochloride from microemulsion systems with monomeric and polymeric surfactants was investigated. The kinetic properties of the release of promethazine hydrochloride from microemulsion systems were calculated. It was found that a microemulsion of polyoxyethylene (20) cetyl ether mixed with polyoxyethylene (4) lauryl ether reduced the release of promethazine hydrochloride in weight percent. The release of promethazine hydrochloride from microemulsions does not obey Fick’s diffusion but follows a non-Fick’s transport mechanism, as evidenced by the high values of the diffusion exponent (n > 0.5).

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Partition coefficients in mixed surfactant systems

Mehling¹

2013

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Study of chromatographic characteristics of inorganic analytes in biopartitioning micellar chromatography with ion‐pair additives

Cited by 3 publications

References 44 publications

Fundamental Properties of Packing Materials for Liquid Chromatography

Fundamental Properties of Packing Materials for Liquid Chromatography

The use of polyoxyethylene (20) cetyl ether in assessing the hydrophobicity of compounds of biomedical importance and in the process of drug release from microemulsions

Partition coefficients in mixed surfactant systems

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