Study of Circulating Adiponectin Level in Children with Type 1 Diabetes Mellitus in Najran-KSA

Abstract

Background: Adiponectin is a polypeptide hormone produced exclusively by adipocytes and is believed to play a vital role in the pathophysiology of diabetes, especially Type 1 Diabetes. This study aimed to determine the relationship between total plasma adiponectin concentrations and body mass index (BMI), fasting glucose and glycated hemoglobin levels among Saudi children with type 1 diabetes mellitus in Najran city -Najran region Southern KSA. Methods: Two hundred and four Saudi children were enrolled in the study, 132 with type 1 diabetes mellitus were selected as a test group compared with a control group which included 72 apparently healthy volunteers, ages and sex in both groups were matched. Results:The adiponectin level was evaluated with special regard to the control of diabetes, gender, duration of disease, body mass index (BMI). Results showed that the plasma adiponectin concentrations were significantly higher in the diabetic group when compared to the controls, results also revealed a significant negative correlation between the serum levels of Adiponectin ng/ml and age/ year, Duration / Year, FBG mg/dl & BMI Kg ̸ m 2 in the diabetic group, while it revealed a significant positive correlation with HbA1c%. Conclusion:Serum level of adiponectin in uncontrolled type 1 diabetic children was significantly higher than in healthy and good controlled type 1 DM children, it indicate that Adiponectin may play roles in diabetic control.

Value of urinary adiponectin, VCAM-1 and RBP 4 in early diagnosis of kidney damage in children with type 1 diabetes mellitus

“…AdipoR1 can activate adenosine monophosphate-activated protein kinase (AMPK) and plays a vital role in controlling oxidative stress and cell survival within the glomerulus [6,19]. The serum level of adiponectin was significantly elevated in children with poor T1DM control; it was directly associated with HbA1c and negatively correlated with the disease/year [20]. Elevated adiponectin levels in urine were associated with rapid GFR decline, CKD incidence, and persistent DN over six years in adults with T1DM [5].…”