Study of clinical, biochemical and immunological factors determining stability of disease in patients with generalized vitiligo undergoing melanocyte transplantation

Rao, Angoori Gnaneshwar; Gupta, Somesh; Dinda, Amit Kumar; Sharma, Alpana; Sharma, Vaishali; Kumar, Guresh; Mitra, Debdeep; Prashant, Chandravilas Keshvan; Singh, Gagandeep

doi:10.1111/j.1365-2133.2012.10886.x

Cited by 56 publications

(50 citation statements)

References 21 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Rao et al (2012) demonstrated an increase in the quantity of T CD8+ and CD45RO+ lymphocytes in the vitiligo lesion areas, and this increase was related to the lower stability and worse response to treatment with melanocyte transplants. 33 The presence of cytotoxic lymphocytes in the skin lesions has also been demonstrated by other studies. 35,36 In addition to the immunological mechanisms that act in the site, the systemic immunological state of the patient can also influence the pathogenesis and the results of the treatment for vitiligo.…”

Section: Discussionsupporting

confidence: 60%

See 1 more Smart Citation

Evaluation of treatment response to autologous transplantation of noncultured melanocyte/keratinocyte cell suspension in patients with stable vitiligo

Ramos

Ramos³

2017

An. Bras. Dermatol.

View full text Add to dashboard Cite

BackgroundVitiligo is a chronic disease characterized by the appearance of achromic macules caused by melanocyte destruction. Surgical treatments with melanocyte transplantation can be used for stable vitiligo cases. ObjectivesTo evaluate treatment response to the autologous transplantation of noncultured epidermal cell suspension in patients with stable vitiligo.MethodsCase series study in patients with stable vitiligo submitted to noncultured epidermal cell suspension transplantation and evaluated at least once, between 3 and 6 months after the procedure, to observe repigmentation and possible adverse effects. The maximum follow-up period for some patients was 24 months.ResultsOf the 20 patients who underwent 24 procedures, 25% showed an excellent rate of repigmentation, 50% good repigmentation, 15% regular, and 10% poor response. The best results were observed in face and neck lesions, while the worst in extremity lesions (88% and 33% of satisfactory responses, respectively). Patients with segmental vitiligo had a better response (84%) compared to non-segmental ones (63%). As side effects were observed hyperpigmentation of the treated area and the appearance of Koebner phenomenon in the donor area.Study limitationsSome limitations of the study included the small number of patients, a subjective evaluation, and the lack of long-term follow-up on the results. CONCLUSION: Noncultured epidermal cell suspension transplantation is efficient and well tolerated for stable vitiligo treatment, especially for segmental vitiligo on the face and neck.

show abstract

Section: Discussionsupporting

confidence: 60%

“…Rao et al (2012) suggest stability of a year to achieve about 70% success, but the study's sample size was small. 33 In our clinical practice, what is considered for surgical procedures are the patients with clinical stability of at least one year, a parameter considered appropriate by other researchers as well. 21,34 …”

Section: Discussionmentioning

confidence: 99%

Evaluation of treatment response to autologous transplantation of noncultured melanocyte/keratinocyte cell suspension in patients with stable vitiligo

Ramos

Ramos³

2017

An. Bras. Dermatol.

View full text Add to dashboard Cite

show abstract

“…Though the duration of stability is a debatable issue, the Indian Association of Dermatologists, Venereologists, and Leprologists (IADVL) task force has defined stability as 'a patient with no new lesions, no progression of existing lesions and absence of Koebner phenomenon during the past one year' [5]. In a recent study on the issue of vitiligo stability, a time period of 18 months of stable disease was shown to be the most suitable one for undertaking any grafting procedure [6]. Such patients with a stable disease respond well to surgical methods like tattooing, autologous skin grafting procedures like epidermal culture grafting, pure melanocyte culture grafting, epidermal grafting by suction blister technique, thin Thiersch's split skin grafting, or thin split skin miniature punch grafting.…”

Section: Discussionmentioning

confidence: 99%

Autologous Epidermal Grafting Using a Novel Negative Pressure Epidermal Harvesting System in a Case of Stable Vitiligo

Krishna

Thirunavukkarasu

Krishnan

et al. 2016

Cureus

View full text Add to dashboard Cite

Vitiligo is a common pigmentary disorder of the skin with a great amount of social stigma attached to it. Though various medical modalities are available for the treatment of stable vitiligo, surgical modality remains the treatment of choice for stable and localized vitiligo. The surgical options range from simple punch grafting to the recent epidermal harvesting methods using a negative pressure unit. Although successful use of multiple methods of epidermal grafting has been reported, most of them are cumbersome and time-consuming. The new automated epidermal harvesting system now commercially available involves a tool that applies both heat and suction concurrently to normal skin to induce epidermal micrografts. Hence it serves as a safe, quick and cost-effective method without anesthesia, with a very minimal downtime for healing and requires an optimal expertise. The duration of repigmentation seems to be faster and more uniform compared to other procedures. We would like to share our experience with the negative pressure epidermal harvesting method in a patient with stable vitiligo.

show abstract

“…In a recent study on the issue of vitiligo stability, a time period of ‘18 months of stable disease’ was shown to be most suitable one for undertaking any grafting procedure. [9]…”

Section: Introductionmentioning

confidence: 99%

Grafting in vitiligo: How to get better results and how to avoid complications

Majid

2013

J Cutan Aesthet Surg

View full text Add to dashboard Cite

Grafting procedures in vitiligo have become quite popular over the last one or two decades especially in India. Starting with the simplest punch grafting we have now a multitude of different grafting techniques available in vitiligo. All of these grafting procedures are associated with certain complications. In addition there are certain factors and surgical pearls that can go a long way in improving the cosmetic results achieved with any of these grafting techniques. This paper will try to address these specific factors and complications associated with these grafting techniques and the ways and means to avoid them.

show abstract

Study of clinical, biochemical and immunological factors determining stability of disease in patients with generalized vitiligo undergoing melanocyte transplantation

Abstract: Along with clinical stability, the proportion of CD8 and CD45RO cells in skin biopsies might help to determine the stability of the disease and thereby predict the success of transplantation.

Cited by 56 publications

References 21 publications

Evaluation of treatment response to autologous transplantation of noncultured melanocyte/keratinocyte cell suspension in patients with stable vitiligo

Evaluation of treatment response to autologous transplantation of noncultured melanocyte/keratinocyte cell suspension in patients with stable vitiligo

Autologous Epidermal Grafting Using a Novel Negative Pressure Epidermal Harvesting System in a Case of Stable Vitiligo

Grafting in vitiligo: How to get better results and how to avoid complications

Contact Info

Product

Resources

About