Study of clinicopathological factors associated with the occurrence of synchronous multiple gastric carcinomas

When do we miss synchronous gastric neoplasms with endoscopy?

“…[13][14][15][16] Another recent study suggested that age (older than 65 years) and the degree of intestinal metaplasia in the surrounding mucosa are significant risk factors for multiple gastric carcinomas. 3 Nasu et al 17 followed 143 patients with early gastric cancer who had undergone EMR and found that 16 (11%) patients had synchronous multiple early gastric cancer within 1 year of the initial EMR. According to a recent synchronous multiple gastric cancer study that included 232 lesions, 164 (70.68%) lesions were consistent with mucosal or submucosal lesions.…”

“…Such therapies conserve function, but after resection, a large quantity of the gastric mucosa remains in which further carcinomas may arise, and concurrent multiple carcinomas and the development of posttherapeutic asynchronous multiple carcinomas represent serious problems. 3 Therefore, accurate initial detection of synchronous multiple gastric cancers is critical.…”

“…Therefore, accurate detection of synchronous multifocal gastric cancer is mandatory. 3 Upper endoscopy is an effective method for discovering gastric adenoma or carcinoma screening and prevention. However, little is known about the accuracy of upper endoscopy for the detection of early gastric cancer.…”

Endoscopic ultrasonography is valuable for identifying early gastric cancers meeting expanded-indication criteria for endoscopic submucosal dissection

“…1, 2). Moreover, it should also be remembered that diffuse HGGs in the submucosa have the potential to increase the risk of multiple gastric cancers [30,31].…”

Multifocal gastric cancer with a variety of histological findings coexisting with hyperplastic polyps: Report of a case

“…5 Some authors consider that the large areas of intestinal metaplasia and dysplasia, frequently seen in elderly patients, are precursors of multifocality. 10,11 Concerning the histologic background of gastric cancer, Nakamura et al 12 argued that the differentiated type was closely associated with intestinal metaplasia and that the undifferentiated type was closely associated with the proper gastric mucosa. According to Bearzi and Ranaldi, 13 the degree of intestinal metaplasia is greater in highly differentiated, early-stage multifocal gastric cancers than in monofocal gastric cancers.…”