Study of Coagulation Profile and Platelet Counts in Pre Eclamptic and Eclamptic Patients

Agrawal, Vishal

doi:10.18535/jmscr/v7i1.99

Cited by 1 publication

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References 12 publications

(22 reference statements)

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“…15 However, the extent of the coagulation problems caused by PE is unknown. Several studies have found that preeclamptic mothers have prolonged prothrombin time (PT) and activated partial thromboplastin time (APTT), [18][19][20][21][22] increased D-dimer levels, 8,17,20,23,24 and decreased levels of natural coagulation inhibitors: antithrombin III (ATIII), protein S (PS), and protein C (PC). [25][26][27][28][29] Despite the evidence of dysregulated coagulation parameters and natural anticoagulants in PE, the diagnostic potential of these parameters in predicting PE has not been explored among Ghanaian pregnant women which is a concerning limitation.…”

Section: Introductionmentioning

confidence: 99%

Coagulation Factors and Natural Anticoagulants as Surrogate Markers of Preeclampsia and Its Subtypes: A Case–Control Study in a Ghanaian Population

Mintaah,

Anto,

Boadu

et al. 2023

Clin Appl Thromb Hemost

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Preeclampsia (PE) is associated with endothelial injury and hemostatic abnormalities. However, the diagnostic role of coagulation parameters and natural anticoagulants in predicting PE has not been explored in Ghana. This study assessed plasma levels of these factors as surrogate markers of PE and its subtypes. This case–control study included 90 women with PE (cases) and 90 normotensive pregnant women (controls). Blood samples were drawn for the estimation of complete blood count and coagulation tests. The prothrombin time (PT), activated partial thromboplastin time (APTT), and the calculation of the international normalized ratio (INR) were determined by an ACL elite coagulometer while the levels of protein C (PC), protein S (PS), antithrombin III (ATIII), and D-dimers were also measured using the solid-phase sandwich enzyme-linked immunosorbent assay (ELISA) method. All statistical analyses were performed using the R Language for Statistical Computing. Results showed significantly ( p < .05) shortened APTT (28.25 s) and higher D-dimer levels (1219.00 ng/mL) among PE women, as well as low levels of PC (1.02 µg/mL), PS (6.58 µg/mL), and ATIII (3.99 ng/mL). No significant difference was found in terms of PT and INR. From the receiver operating characteristic analysis, PC, PS, and ATIII could significantly predict PE and its subtypes at certain cutoffs with high accuracies (area under the curve [AUC] ≥0.70). Most women with PE are in a hypercoagulable state with lower natural anticoagulants. PC, PS, and ATIII are good predictive and diagnostic markers of PE and its subtypes (early-onset PE [EO-PE] and late-onset PE [LO-PE]) and should be explored in future studies.

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