Study of compaction-free fabrication of topologically ordered functionally graded iron-hydroxyapatite-zinc biodegradable composite implants

Tripathi, Gaurav; Pandey, Pulak Mohan

doi:10.1007/s10853-024-09786-z

J Mater Sci

2024

DOI: 10.1007/s10853-024-09786-z

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Study of compaction-free fabrication of topologically ordered functionally graded iron-hydroxyapatite-zinc biodegradable composite implants

Gaurav Tripathi,

Pulak Mohan Pandey

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2024

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Cited by 2 publications

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In vitro degradation behavior, cytocompatibility and hemocompatibility of topologically ordered functionally graded iron-hydroxyapatite-zinc composite biodegradable biomaterial fabricated using 3D printing and pressureless microwave sintering

Tripathi,

Pandey

2024

RPJ

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Purpose Topologically ordered functionally graded composite (TOFGC) biodegradable materials are needed in the field of metallic degradable implants, as they degrade over a period of time avoiding the necessity of another surgery for implant removal. Also, their rate of degradation can be tailored to match the requirement of the patient. These biomaterials also have the functionality to assist bone growth and eliminate stress shielding in orthopaedic implants. Design/methodology/approach In this study, TOFGC biomaterials were developed for the first time using additive manufacturing, pressureless microwave sintering and casting methods, and their cytocompatibility, hemocompatibility and in vitro degradation evaluations were done. Also, pure dense iron and iron scaffolds were included in the study, for the comparison of results with the iron-hydroxyapatite-zinc functionally graded composite biomaterial. Findings The maximum weight loss and corrosion rate were found to be 6.98% and 2.38 mmpy, respectively, in the immersion test and electrochemical test for Fe-3.5HAp-54Zn biomaterial. Zinc-infiltrated composite biomaterials exhibited excellent cytocompatibility and hemocompatibility as compared to pure dense iron and iron scaffolds. A comparative analysis was conducted, taking into account relevant literature, and it was determined that the fabricated iron-hydroxyapatite-zinc biomaterial demonstrated desirable degradation and biological characteristics, customized to meet the specific requirements of bone tissue engineering applications. Originality/value TOFGC iron-hydroxyapatite-zinc biomaterial has been fabricated for the first time using the developed novel methodology and their degradation and biological characterizations were performed.

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In vitro degradation behavior, cytocompatibility and hemocompatibility of topologically ordered functionally graded iron-hydroxyapatite-zinc composite biodegradable biomaterial fabricated using 3D printing and pressureless microwave sintering

Tripathi,

Pandey

2024

RPJ

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A review on the mechanical and biocorrosion behaviour of iron and zinc-based biodegradable materials fabricated using powder metallurgy routes

Das,

Pathak,

Sharma

et al. 2024

Corrosion Reviews

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Over the past two decades, research on alloys and composites based on Mg, Fe, and Zn has focused on biodegradable orthopaedic implants. Mg-based materials face issues like excessive corrosion rates and hydrogen gas evolution, while Fe and Zn-based materials show lower corrosion rates. However, these rates are slower than the optimal rate, which can be modified using powder metallurgy (PM) manufacturing. The PM process offers precise control over porosity distribution which in turn affects the mechanical and corrosion properties of the fabricated specimen. The highest rate of corrosion i.e. 0.944 mmpy was observed with the alloying of 2 wt% Pd in Fe and by using conventional sintering technique. Similarly, Zn-based samples fabricated by conventional sintering was found to exhibit higher corrosion rate as compared to microwave and spark plasma sintered specimen. PM-fabricated Fe and Zn-based bone scaffolds have been investigated for in-vitro corrosion and osseointegration. A higher porosity in the Fe and Zn scaffolds (>60 %) resulted in high corrosion rate which adversely impacted the cell proliferation. This timely review critically assessed PM-fabricated Fe and Zn-based materials that have the potential to transform regenerative medicine and patient care by redefining the field of biodegradable implants.

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Study of compaction-free fabrication of topologically ordered functionally graded iron-hydroxyapatite-zinc biodegradable composite implants

Cited by 2 publications

References 52 publications

In vitro degradation behavior, cytocompatibility and hemocompatibility of topologically ordered functionally graded iron-hydroxyapatite-zinc composite biodegradable biomaterial fabricated using 3D printing and pressureless microwave sintering

In vitro degradation behavior, cytocompatibility and hemocompatibility of topologically ordered functionally graded iron-hydroxyapatite-zinc composite biodegradable biomaterial fabricated using 3D printing and pressureless microwave sintering

A review on the mechanical and biocorrosion behaviour of iron and zinc-based biodegradable materials fabricated using powder metallurgy routes

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