Study of Composition and Morphology of Cadmium Oxide (CdO) Nanoparticles for Eliminating Cancer Cells

Abstract

The effects of substrate temperature on the structural, optical, medical and electrical characteristics of Cadmium Oxide (CdO) films are investigated in the current study. Films are deposited on glass substrate at different temperatures, ranged between 450-600 ºC, using Spray Pyrolysis Technique. According to XRay Diffraction (XRD), it is found that the films are polycrystalline and Cadmium Oxide (CdO) is of a hexagonal wurtzite structure which the preferred direction of its crystal plane is (002). The maximum optical transmittance of films is more than 85%. The size of crystallites is calculated with the maximum value in 500º C. Furthermore, Cadmium Oxide (CdO) nanoparticles were synthesized in deionized water by laser ablation of Cadmium plate. In the current paper, the effects of laser pulse energy and wavelength on the characteristics of Cadmium Oxide (CdO) nanoparticles were studied. Analyses of Transmission Electron Microscope (TEM) were confirmed that size distribution of Cadmium Oxide (CdO) nanoparticles is reduced by increase in laser pulse energy. Fluorescence spectrum of Cadmium Oxide (CdO) nanoparticles shows violet emission accompanied by blue and green band. UV emission with high intensity shows that nanostructure of Cadmium Oxide (CdO) is of a little deficiency. Also, the current study aims to study the linear and non-linear optical characteristics of Cadmium Oxide (CdO) nanoparticles and their applications. Firstly, fluorescence spectrum, as a linear characteristics of Cadmium Oxide (CdO), as well as second harmonic generation and two photons absorption, as non-linear characteristics of Cadmium Oxide (CdO), are studied. Then, some aspects of medicinal and pharmaceutical applications of Cadmium Oxide (CdO) nanoparticles for eliminating cancer cells such as the effect of Cadmium Oxide (CdO) nanoparticles on DNA of human cancer cells and the interaction of Cadmium Oxide (CdO) nanoparticles with DNA of cancer cells are originally investigated. It should be noted that the range of considered parameters are separately clarified and explained in each of related sections (Figure 1).

Green and Chemical Syntheses of CdO NPs: A Comparative Study for Yield Attributes, Biological Characteristics, and Toxicity Concerns

“…The most widely known applications of CdO NPs are in optoelectronics, phototransistors, photodiodes, solar cells, and gas sensors . CdO NPs opened new horizons to eliminate cancer cells and targeted drug delivery. , CdS nanoparticles are also used as a fluorescence probe in the determination of nucleic acids based on the synchronous fluorescence quenching of functionalized CdS in the presence of DNA. , The antimicrobial activity of CdO NPs is remarkable against several antibiotic-resistant pathogenic bacteria. , …”

Anchoring of Nanocomposites Based on Novel Metal Nanocomplexes/Nanocarbonaceous Surfaces and Assessing Their In Vivo Anticancer Effects on Ehrlich Ascites Tumor

“…Cadmium nanocomplex-based therapy has developed as a novel branch of nano-based therapeutics in this regard. 19 3.1. Effect of Cd Nanocomplex Therapy on Tumor Growth and Survival Status (after 36 Days).…”

“…The major method of action of the Cd nanocomplex on cancer cells is DNA and protein damage, as well as cell-wall breakdown. 19 3.2. Effect of Cd Nanocomplex Therapy on Inflammatory, Pyroptosis, Epigenetic Instability, Oxidative Stress, and Antioxidant Biomarkers.…”

“…Cadmium nanocomplex-based therapy has developed as a novel branch of nano-based therapeutics in this regard. 19 …”

“…The major method of action of the Cd nanocomplex on cancer cells is DNA and protein damage, as well as cell-wall breakdown. 19 …”