Study of cord blood nucleated RBC’s as a marker for fetal asphyxia

Ganta, Suvarna Jyothi; Kulkarni, Sunanda R.

doi:10.18203/2320-1770.ijrcog20170402

Cited by 3 publications

(4 citation statements)

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“…The APGAR scores were inversely proportional to nRBC count. This was comparable to the study done by Ganta S.J et al [9] and Colacoa et a The present study showed a strong correlation between the NRBCs and severity of birth asphyxia. The meannRBC count was 19.1 in stage 1 HIE, 31 in stage 2 HIE and 54.3 in stage 3 HIE.…”

Section: Discussionsupporting

confidence: 93%

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Study of nucleated RBC count as a marker of severity of perinatal asphyxia in newborns - a case control study

Sandhya

et al. 2018

Int J Pediatr Res

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Introduction: This study was done to estimate the nucleated red blood cell count (NRBCs) in normal and asphyxiated babies and find their correlation with severity of birth asphyxia. Materials and Methods: About 50 normal newborns as control and 50 newborns with perinatal asphyxia as cases were considered. At birth 2 mL of venous blood was collected in both cases and control groups. nRBC count per 100 white blood cells (WBC) was done at admission. Clinical assessments in terms of neurologic status at birth, 24 hours after birth and every day thereafter till discharge/death was done. Cord blood nRBC/100 WBC was correlated with stages of HIE during hospital stay. Neonates were monitored for adverse outcome such as tone abnormalities, feeding difficulty, refractory seizures and death. Controls were followed up in the same manner. Results: Among 50 cases, 24 had no hypoxic ischaemic encephalopathy (HIE),17 had stage 1 HIE, 6 had stage 2 and 3 newborns had stage 3 HIE. The mean APGAR score in cases was 5.34 ± 1.19 whereas for the control group it was 8.12 ± 0.77 with p value of 0.001 which is statistically significant. The mean nRBC in newborns with APGAR score of 3, 4,5, 6 were 35.5, 19.9, 20.6 and 12 respectively. The low APGAR scores showed high nRBCs. Mean nRBCs for HIE stage 1, 2, 3 was 19.1, 31.0, and 54.3 respectively. High nRBC count correlated with increasing severity of birth asphyxia. Conclusion: nRBC count is an easy, simple and a reliable test to assess the severity of birth asphyxia in resource poor settings.

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Section: Discussionsupporting

confidence: 93%

“…The meannRBC count was 19.1 in stage 1 HIE, 31 in stage 2 HIE and 54.3 in stage 3 HIE. Other studies have observed lower number of cord blood nRBCsin severe birth asphyxia compared to our study [9,10,13,17].…”

Section: Discussioncontrasting

confidence: 66%

Study of nucleated RBC count as a marker of severity of perinatal asphyxia in newborns - a case control study

Sandhya

et al. 2018

Int J Pediatr Res

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“…Several studies have reported an increased NRBC in neonatal cord blood following perinatal asphyxia. [14][15][16][17] Studies done by Ganta et al and Hemlatha et al, reported 11.6±5.736 and 15.74±3.58 NRBC respectively, which was nearly similar to present study observations. 14,15 The mean cord blood NRBC observed by Kumar et al and Khurana et al was 20.97±8.17 and 21.40±20.31 respectively.…”

Section: Nrbc As a Predictor Of Birth Asphyxiasupporting

confidence: 91%

“…[14][15][16][17] Studies done by Ganta et al and Hemlatha et al, reported 11.6±5.736 and 15.74±3.58 NRBC respectively, which was nearly similar to present study observations. 14,15 The mean cord blood NRBC observed by Kumar et al and Khurana et al was 20.97±8.17 and 21.40±20.31 respectively. 16,17 Values in the latter two studies were higher than the present study because they included newborns with Apgar score <7 at 5 min and the newborns that required positive pressure ventilation at birth.…”

Section: Nrbc As a Predictor Of Birth Asphyxiasupporting

confidence: 91%

Cord blood and peripheral nucleated red blood cells levels in term asphyxiated and non-asphyxiated new borns and neonatal outcome: a comparative study

Chauhan

Jaipal²,

Bisht

et al. 2021

Int J Contemp Pediatr

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Background: Perinatal asphyxia can cause severe hypoxic-ischemic damages in the organs and causes severe long-term consequences. It has recently been suggested that the increase in NRBC count in the umbilical vein of newborns can be considered a sign of birth asphyxia. The aim of the study was to evaluate the role of cord blood nucleated RBC count as a marker for presence and severity of birth asphyxia.Methods: This prospective observational comparative study was conducted among 30 asphyxiated (case) and 30 non-asphyxiated newborns (control) in Swami Dayanand Hospital. Number of nucleated red blood cells in cord blood and peripheral blood were counted per 100 leukocytes in smears in cases and control. Maternal parameters and neonate characteristics were recorded in a proforma.Results: NRBC count increased in cord blood during the first few hours of life in perinatal asphyxia (10.79±9.58) as compared with the healthy control subjects (4.03±2.87, p=0.002). Significant positive correlation of C-NRBC and P-NRBC with NICU stay (r=0.921, p<0.0001 and r=0.698, p<0.0001 respectively). Nucleated RBC count more than 18 can be used as predictor of abnormal neurological outcome with sensitivity 100% and specificity of 93.1%. The cord blood NRBC >3/100 WBC has sensitivity of 92% and specificity of 77.8% in predicting birth asphyxia.Conclusions: Nucleated RBC count can be used as surrogate marker for birth asphyxia. It has significant positive correlation with severity of hypoxic ischemic encephalopathy, duration of NICU stay and duration of O2 requirement.

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Comparative Study to Correlate Hematological Parameters with the Severity of Birth Asphyxia

Mamatha,

Meena,

Sulaniya

et al. 2023

CHRISMED Journal of Health and Research

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Introduction: Birth asphyxia can alter biophysical characteristics of erythrocytes, leukocytes and platelets. Nucleated red blood cell (NRBC) in the umbilical venous blood of neonates has been reported as a possible marker of perinatal asphyxia. NRBCs, platelet count, total leukocyte count, hemoglobin, and hematocrit were taken as hematological parameters. The purpose of this study was to evaluate the various hematological changes following birth asphyxia and their correlation with the severity of birth asphyxia and its outcome. Materials and Methods: It was hospital-based comparative observation study conducted in neonatal units of a tertiary hospital in the northern part of India from May 2019 to May 2020. All term appropriate for gestational age newborns with birth asphyxia were taken as cases and healthy newborns as controls. The sample size of 80 participants in each group was calculated. 2 ml cord blood sample was taken for parameters used in the study. P < 0.05 was taken as statistically significant. Results: There was no statistically significant difference in relation to sex distribution, birth weight, parity of mothers, and mode of delivery between cases and controls. NRBC and total leukocyte count were statistically positively correlated with the severity of hypoxic-ischemic encephalopathy (HIE), whereas hemoglobin, hematocrit, and platelet counts were not statistically significant. Area under the Receiver operating characteristic (ROC) curve of NRBC was 0.812, and the NRBC count cutoff of >20 has a sensitivity of 83% and specificity of 72%. Forty-six percent of total cases with NRBC 20 or more died. Conclusions: NRBC has a significant positive correlation with the severity of HIE and a negative with the Apgar score. NRBCs value more than or equal to 20 can be used as a prognostic marker for assessing the severity and outcome of birth asphyxia.

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Study of cord blood nucleated RBC’s as a marker for fetal asphyxia

Cited by 3 publications

References 9 publications

Study of nucleated RBC count as a marker of severity of perinatal asphyxia in newborns - a case control study

Study of nucleated RBC count as a marker of severity of perinatal asphyxia in newborns - a case control study

Cord blood and peripheral nucleated red blood cells levels in term asphyxiated and non-asphyxiated new borns and neonatal outcome: a comparative study

Comparative Study to Correlate Hematological Parameters with the Severity of Birth Asphyxia

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