Study of Costus lucanusianus: plant juice, fraction combinations and pharmacologie estimation of natural product total activity

Foungbe, S; Kouassi, G.; Kablan, J; Marcy, R.

doi:10.1016/0378-8741(91)90080-w

Cited by 12 publications

(6 citation statements)

References 0 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Although it is ineffective against MHH-ES-1 and primary Ewing sarcoma cells, TT appears to potentiate the effect of viscum, creating the synergistic effect of viscumTT. Our data correlates with the well-known phytopharmacological phenomenon that a naturally existing combination is often more effective than the single compounds [38,39]. …”

Section: Discussionsupporting

confidence: 85%

Multiple Active Compounds from Viscum album L. Synergistically Converge to Promote Apoptosis in Ewing Sarcoma

Twardziok

Kleinsimon

Rolff³

et al. 2016

PLoS ONE

View full text Add to dashboard Cite

Ewing sarcoma is the second most common bone cancer in children and adolescents, with poor prognosis and outcome in ~70% of initial diagnoses and 10–15% of relapses. Hydrophobic triterpene acids and hydrophilic lectins and viscotoxins from European mistletoe (Viscum album L.) demonstrate anticancer properties, but have not yet been investigated for Ewing sarcoma. Commercial Viscum album L. extracts are aqueous, excluding the insoluble triterpenes. We recreated a total mistletoe effect by combining an aqueous extract (viscum) and a triterpene extract (TT) solubilized with cyclodextrins. Ewing sarcoma cells were treated with viscum, TT and viscumTT in vitro, ex vivo and in vivo. In vitro and ex vivo treatment of Ewing sarcoma cells with viscum inhibited proliferation and induced apoptosis in a dose-dependent fashion, while viscumTT combination treatment generated a synergistic effect. Apoptosis occurred via intrinsic and extrinsic apoptotic pathways, evidenced by activation of both CASP8 and CASP9. We show that viscumTT treatment shifts the balance of apoptotic regulatory proteins towards apoptosis, mainly via CLSPN, MCL1, BIRC5 and XIAP downregulation. ViscumTT also demonstrated strong antitumor activity in a cell line- and patient-derived mouse model, and may be considered an adjuvant therapy option for pediatric patients with Ewing sarcoma.

show abstract

Section: Discussionsupporting

confidence: 85%

Multiple Active Compounds from Viscum album L. Synergistically Converge to Promote Apoptosis in Ewing Sarcoma

Twardziok

Kleinsimon

Rolff³

et al. 2016

PLoS ONE

View full text Add to dashboard Cite

show abstract

“…Each CHM is a mixture of multiple compounds. Many CHMs are biologically active, while individual substituents may not exhibit bioactivity, suggesting that multiple components of an herb have synergistic effects [ 41 , 42 ]. In addition, in TCM, formulas are used more frequently.…”

Section: Discussionmentioning

confidence: 99%

Identification of the Mechanism of Matrine Combined with Glycyrrhizin for Hepatocellular Carcinoma Treatment through Network Pharmacology and Bioinformatics Analysis

Han

Liu

Chen

et al. 2022

Oxidative Medicine and Cellular Longevity

View full text Add to dashboard Cite

Matrine and glycyrrhizin are representative active ingredients of traditional Chinese medicine (TCM) used in clinical practice. Studies have demonstrated that matrine has antitumor pharmacological effects and that glycyrrhizin protects liver function. However, the potential bioactive compounds and mechanisms remain unknown, as well as whether they have synergistic effects in killing cancer cells and protecting liver cells. To investigate the synergistic effects and mechanism of matrine combined with glycyrrhizin in hepatocellular carcinoma (HCC) treatment, we used both network pharmacology and bioinformatics analyses. First, the chemical gene interaction information of matrine and glycyrrhizin was obtained from the PubChem database. The pathogenic genes of HCC were accessed from five public databases. The RNA sequencing data and clinical information of HCC patients were downloaded from The Cancer Genome Atlas (TCGA). Next, the overlapping genes among the potential targets of matrine and glycyrrhizin and HCC-related targets were determined using bioinformatics analysis. We constructed the drug-target interaction network. Prognosis-associated genes were acquired through the univariate Cox regression model and Lasso-Cox regression model. The results were verified by the International Cancer Genome Consortium (ICGC) database. Finally, we predicted the immune function of the samples. The drug-target interaction network consisted of 10 matrine and glycyrrhizin targets. We selected a Lasso-Cox regression model consisting of 3 differentially expressed genes (DEGs) to predict the efficacy of the combination in HCC. Subsequently, we successfully predicted the overall survival of HCC patients using the constructed prognostic model and investigated the correlation of the immune response. Matrine and glycyrrhizin have synergistic effects on HCC. The model we obtained consisted of three drug-target genes by Lasso-Cox regression analysis. The model independently predicted the combined effect of matrine and glycyrrhizin in HCC treatment and OS, which will be helpful for guiding clinical treatment. The prognostic model was correlated with the immune cells and immune checkpoints of patients, which had an adjuvant effect on HCC immunotherapy. Matrine and glycyrrhizin can have therapeutic effects on HCC by promoting the production or enhancing the core gene activity in the drug network and improving the immune system function of patients.

show abstract

“…92 This concept is hardly unfamiliar, traditional Chinese medicine has used mixtures of herbs and their extracts in their therapy, and the activities of these therapies disappear when the components were fractionated into individual components. 93 Well known successes of FDC drugs include the GlaxoSmithKline blockbuster Advair for asthma, which was found in at least one meta-analysis study to be synergistic in efficacy when compared with concomitant use of two separate inhalers. 94 Another blockbuster success comes from the joint venture (Merck and Schering-Plough) against hyperlipidaemia called Vytorin (combining Zetia and Zocor), which works in two different mechanisms of action; Zetia blocks cholesterol absorption, and Zocor reduces cholesterol naturally produced in the body.…”

Section: Practical Approaches To Generate Promiscuous Drugsmentioning

confidence: 99%

Molecular Networks in Drug Discovery

Morrow

Tian

Zhang³

2010

Crit Rev Biomed Eng

View full text Add to dashboard Cite

Despite the dramatic increase of global spending on drug discovery and development, the approval rate for new drugs is declining, due chiefly to toxicity and undesirable side effects. Simultaneously, the growth of available biomedical data in the post-genomic era has provided fresh insight into the nature of redundant and compensatory drug-target pathways. This stagnation in drug approval can be overcome by the novel concept of polypharmacology, which is built on the fundamental concept that drugs modulate multiple targets. Polypharmacology can be studied with molecular networks which integrate multidisciplinary concepts including cheminformatics, bioinformatics, and systems biology. In silico techniques such as structure and ligand-based approaches can be employed to study molecular networks and reduce costs by predicting adverse drug reactions and toxicity in the early stage of drug development. By amalgamating strides in this informatics-driven era, designing polypharmacological drugs with molecular network technology exemplifies the next generation of therapeutics with less off-target properties and toxicity. In this review, we will first describe the challenges in drug discovery, and showcase successes using multi-target drugs toward diseases such as cancer and mood disorders. We will then focus on recent development of in silico polypharmacology predictions. Finally, our technologies in molecular network analysis will be presented.

show abstract

Study of Costus lucanusianus: plant juice, fraction combinations and pharmacologie estimation of natural product total activity

Cited by 12 publications

References 0 publications

Multiple Active Compounds from Viscum album L. Synergistically Converge to Promote Apoptosis in Ewing Sarcoma

Multiple Active Compounds from Viscum album L. Synergistically Converge to Promote Apoptosis in Ewing Sarcoma

Identification of the Mechanism of Matrine Combined with Glycyrrhizin for Hepatocellular Carcinoma Treatment through Network Pharmacology and Bioinformatics Analysis

Molecular Networks in Drug Discovery

Contact Info

Product

Resources

About