Study of Culture and Sensitivity Patterns of Urinary Tract Infections in Patients Presenting with Urinary Symptoms in a Tertiary Care Hospital

Muzammil, Muhammad; Adnan, Muhammad; Sikandar, Sheikh Muhammad; Waheed, Muhammad Umar; Javed, Naseem; Rehman, Muhammad Fazal Ur

doi:10.7759/cureus.7013

Cited by 7 publications

(10 citation statements)

References 16 publications

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Section: Discussionmentioning

confidence: 99%

“…Various urine culture studies in Pakistan have reported E. coli as the most common uropathogen ranging from 52%-77.4 % [24][25][26][27][28][29]. Another common organism was Klebsiella pneumoniae ranging from 1.9%-18.69% [24][25][26][27][28][29]. Few of the other uropathogens reported were Pseudomonas aeruginosa, Enterobacter, and Proteus mirabilis [24][25][26][27][28][29] After the discovery of penicillin, antibiotics have revolutionized healthcare.…”

Section: Discussionmentioning

confidence: 99%

“…Another common organism was Klebsiella pneumoniae ranging from 1.9%-18.69% [24][25][26][27][28][29]. Few of the other uropathogens reported were Pseudomonas aeruginosa, Enterobacter, and Proteus mirabilis [24][25][26][27][28][29] After the discovery of penicillin, antibiotics have revolutionized healthcare. No doubt, it has played a significant role in decreasing the mortality rate of various infections.…”

Section: Discussionmentioning

confidence: 99%

“…According to a study by Muzamil et al, “almost more than 60% of the total sample were resistant to co-amoxiclav, cefotaxime, and ceftriaxone, piperacillin/tazobactam, cefoperazone/sulbactam, and ciprofloxacin. All 100% cultures were resistant to amoxicillin” [ 25 ]. Their findings are similar to our study except for cefoperazone/sulbactam which showed better sensitivity in our study.…”

Section: Discussionmentioning

confidence: 99%

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Uropathogens Antimicrobial Sensitivity and Resistance Pattern From Outpatients in Balochistan, Pakistan

Hussain¹,

Moqadasi²,

Malik³

et al. 2021

Cureus

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To determine the pattern of microbes responsible for urinary tract infections and their susceptibility to different antibiotics. MethodThis is a cross-sectional study conducted at Quetta, Pakistan. The urine samples of 400 patients were collected and sent for culture and sensitivity analysis. The results were recorded on an excel datasheet. Descriptive statistics were used to describe the data. ResultsOut of 400 urine samples, 266 samples were culture positive for microorganisms. The most common organism on analysis was Escherichia coli 123/266 (46.24%) followed by Staphylococcus saprophyticus 59/266 (22.18%) and Klebsiella pneumonia 49/266 (18.42%). Gram-negative microorganisms were most susceptible to fosfomycin, cefoperazone/sulbactam, and meropenem. Gram-positive microorganisms were most susceptible to fosfomycin, cefoperazone/sulbactam, meropenem, and amoxicillin/clavulanate. High rates of resistance in E. coli were observed to most commonly prescribed broad-spectrum antibiotics; ceftriaxone (64.35%), cefotaxime (76.54%), ceftazidime (49.43%), cefepime (53.44%), levofloxacin (71.26%), and amoxicillin/clavulanate (70.31%). E. coli was the major multidrug-resistant organism. ConclusionHigh rates of antibiotic resistance and multi-drug resistance were revealed in this study due to the widespread and injudicious use of broad-spectrum antibiotics. Thus, it is highly recommended to regulate the pharmacies. Physicians should judiciously prescribe antibiotics and practice the culture and sensitivity of urine samples rather than blind prescription. Continued surveillance on uropathogens prevalence and resistance, new and next-generation antibiotics, and rapid diagnostic tests to differentiate viral from bacterial infections is the need of time.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

See 2 more Smart Citations

Uropathogens Antimicrobial Sensitivity and Resistance Pattern From Outpatients in Balochistan, Pakistan

Hussain¹,

Moqadasi²,

Malik³

et al. 2021

Cureus

View full text Add to dashboard Cite

show abstract

“…The plates were read after 24 hours of aerobic incubation at a temperature of 37Cº. They were then further incubated for another 24 hours before a negative report was issued 13 .…”

Section: Methodsmentioning

confidence: 99%

Antimicrobial Sensitivity Pattern of Urine Culture Isolate in a tertiary Care Hospital

Karmani¹,

Ahmad²,

Iqbal³

et al. 2023

PJMHS

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Aim: To observe sensitivity patterns of urinary tract infections and the micro-organisms causing them in patients presenting with urinary tract symptoms. Methodology: A sample of 206 patients presenting with complaints of lower urinary tract symptoms and ranging between the age group of 20 to 85 years was included in the study. This was a retrospective study that was carried out in the departments of nephrology at Dr. Akbar Niazi Teaching Hospital (ANTH), Islamabad, from January 2019 to January 2020. Urine samples were collected in sterile containers and processed. Culture and sensitivity analysis based on investigative testing was carried out. CLED medium was used to sub-culture the colonies to get pure growth of the micro-organisms. The Kirby-Bauer disc diffusion process was employed to find the susceptibility of antibiotic in isolated colonies.The bacterial growth was measured after incubation in compliance with the clinical and laboratory standards institute (CLSI) guidelines. Results: Escherichia Coli was detected in 77 patients (84.6%) among the 91 positive urine cultures; Klebsiella species was found in 7 patients (7.7%); Enterococcus species was present in 6 patients (6.6%) and Pseudomonas was found in 1 patient (1.1%). Maximum efficacy was observed with Imipenem and Fosfomycin (80.5%) followed by Nitrofurantoin (75.3%). All cultures were resistant to Amoxicillin. Conclusion: Our study shows, Imipenem and Fosfomycin to be the most effective drugs in treatment of UTIs. E coli remains the most common causative organism in this disease and the increase in drug resistance by uropathogens are of significant concern.Communities may benefit from implementation of health education to prevent antibiotic sharing and similar drug abuse. Keyword: Anti-infective agents; Culture; Microbial sensitivity tests; Urine; Uropathogens; Urinary tract infections.

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Vaccinium macrocarpon Based Fe-Doped Zno Nanoparticles as an Alternate Against Resistant Uropathogens

Sardar,

Rahman,

Khan

et al. 2024

BioNanoSci.

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Study of Culture and Sensitivity Patterns of Urinary Tract Infections in Patients Presenting with Urinary Symptoms in a Tertiary Care Hospital

Abstract: To study the culture and sensitivity patterns of urinary tract infections in patients presenting with urinary symptoms in a tertiary care hospital. Study design A cross-sectional study.

Cited by 7 publications

References 16 publications

Uropathogens Antimicrobial Sensitivity and Resistance Pattern From Outpatients in Balochistan, Pakistan

Uropathogens Antimicrobial Sensitivity and Resistance Pattern From Outpatients in Balochistan, Pakistan

Antimicrobial Sensitivity Pattern of Urine Culture Isolate in a tertiary Care Hospital

Vaccinium macrocarpon Based Fe-Doped Zno Nanoparticles as an Alternate Against Resistant Uropathogens

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