Study of curcumin and genistein interactions with human serum albumin

Mandeville, J. S.; Froehlich, E.; Tajmir-Riahi, H.A.

doi:10.1016/j.jpba.2008.11.035

Cited by 199 publications

(83 citation statements)

References 47 publications

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“…These results were in agreement with Zhongfa et al who reported that PEG400 was capable of solubilizing curcumin to a higher extent (Zhongfa et al, 2012). W.W. Quitschke (2012) explained the solubilization power of PEG by its amphiphilic properties confirming Mandeville et al (2009) andSun et al (2008) observations that curcumin requires hydrophobic and hydrophilic moieties balance, in addition they described the solubility behavior of curcumin as amphipathic.…”

Section: Solubility Studysupporting

confidence: 91%

Formulation, in-vitro characterization and clinical evaluation of curcumin in-situ gel for treatment of periodontitis

et al. 2017

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This study aimed to develop syringeable in-situ curcumin (cur) gel for the treatment of periodontal pockets as well as to evaluate the clinical efficacy of Cur in-situ gel formulation. Different in-situ gel formulations of Cur were prepared using 30% of pluronic F127, and 1% of carbopol P934. The formulations were evaluated regarding gelation temperature, pH, viscosity, syringeability study, in-vitro release and chemical stability of cur. The effect of aging of gel formulations for 3months in refrigerator was investigated. The selected formulation was clinically evaluated through the determination of probing depth, plaque index, and bleeding index at baseline and 1 month after application. The formulations showed accepted gelation temperature ranging from 28 to 34 C and all had pH value of 4. The viscosity of the formulations at 4 C ranged from 19 000 to 37 000 cP. All formulations were easily syringeable through 21 gauge needle at cold temperature. Curcumin stability during the release study was maintained. Aging showed no significant effect on release profile, drug content, or the pH after 3 months, while it showed a slight increase in viscosity with concomitant decrease in gelation temperature. Selected formulations delivered into periodontal pocket evaluated clinically showed to be effective. The treated group revealed that the adjunctive use of intracrevicular 2% curcumin in-situ gel adjunct to mechanical treatment in patients with adult periodontitis could aid in significant clinical reduction of probing depth, bleeding index, and to less extent of plaque. This indicates that curcumin in this novel drug delivery system is an excellent candidate for periodontal disease treatment.

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Section: Solubility Studysupporting

confidence: 91%

Formulation, in-vitro characterization and clinical evaluation of curcumin in-situ gel for treatment of periodontitis

et al. 2017

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“…This wide structural variation, including their substituents, has given to polyphenols their different levels of anti-AGEs and anti-diabetic activities demonstrated in vivo and in vitro studies (Xie et al, 2013;Klein et al, 2011b). While the original paradigm indicated the antiglycative effect of polyphenols was due to their free radical scavenging potential, new evidence of scavenging-independent protection has emerged (Vlassopoulos et al, 2013;Sadowska-Bartosz et al, 2014;Mandeville et al, 2009). …”

Section: Introductionmentioning

confidence: 99%

Nutritional intervention and impact of polyphenol on glycohemoglobin (HbA1c) in non-diabetic and type 2 diabetic subjects: Systematic review and meta-analysis

Palma-Duran

Vlassopoulos

Lean

et al. 2016

Critical Reviews in Food Science and Nutrition

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Polyphenols have been extensively studied for their antioxidant and anti-inflammatory properties.Recently, their antiglycative actions by oxidative stress modulation have been linked to prevention of diabetes and associated complications. This paper assesses the evidence for polyphenol interventions on glycohaemoglobin (HbA1c) in non-diabetic, pre-diabetic and type 2 diabetes mellitus (T2DM) subjects. A systematic review of polyphenols clinical trials on HbA1c in humans was performed according to the Preferred Reporting Items for Systematic Review and Meta-Analysis. Thirty-six controlled randomized trials with HbA1c values were included.Polyphenols (extracts, supplements, foods), were supplemented (28 mg to 1.5g) for 0.7 to 12 months. Combining all subjects (n=1954, mean baseline HbA1c=7.03%, 53 mmol/mol), polyphenol supplementation significantly (p<0.001) lowered HbA1c% by -0.53±0.12 units (-5.79±0.13 mmol/mol). This reduction was significant (p<0.001) in T2DM subjects, specifically (n=1426, mean baseline HbA1c=7.44%, 58 mmol/mol), with HbA1c% lowered by -0.21±0.04 units (-2.29±0.4 mmol/mol). Polyphenol supplementation had no significant effect (p>0.21) in the non-diabetic (n=258, mean baseline HbA1c=5.47%, 36 mmol/mol) and the pre-diabetic subjects (n=270, mean baseline HbA1c=6.06%, 43 mmol/mol) strata: -0.39±0.27 HbA1c% units (-4.3±0.3 mmol/mol), and -0.38±0.31 units (-4.2±0.31 mmol/mol), respectively. In conclusion, polyphenols can successfully reduce HbA1c in T2DM, without any intervention at glycaemia, and could contribute to the prevention of diabetes complications. [Escriba texto]

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“…Human serum albumin (HSA) with high affinity binding sites is a major transporter for delivering several endogenous compounds and drugs in vivo. Structural analysis showed that genistein binds to HSA via polypeptide polar groups (Mandeville et al, 2009). Binding of genistein to albumins is reversible, rapid and the concentration of unbound isoflavone is in an equilibrium state.…”

Section: Binding Of Genistein To Different Proteinsmentioning

confidence: 99%