Study of degradation of amitriptyline antidepressant by different electrochemical advanced oxidation processes

Melín, Victoria; Salgado, Pablo; Thiam, Abdoulaye; Henríquez, Adolfo; Mansilla, Héctor D.; Yáñez, Jorge; Salazar, Claudio

doi:10.1016/j.chemosphere.2021.129683

Cited by 27 publications

(14 citation statements)

References 56 publications

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“…Thus, they are controlled drugs, so it is necessary to determine trace levels in biological fluids. [39] On the other hand, amitriptyline has been detected in wastewater, drinking water, and groundwater effluents at 3200, 20-23.5, and 7460 ng L À 1 respectively [40] while 582.4 ng L À 1 was detected in hospital effluent in Greece. [41] Today the COVID-19 pandemic has brought changes in lifestyle including social isolation, unemployment, reduction of physical exercise, uncertainty, changes in work and school routine.…”

Section: Antidepressantsmentioning

confidence: 99%

“…Thus, they are controlled drugs, so it is necessary to determine trace levels in biological fluids [39] . On the other hand, amitriptyline has been detected in wastewater, drinking water, and groundwater effluents at 3200, 20–23.5, and 7460 ng L −1 respectively [40] while 582.4 ng L −1 was detected in hospital effluent in Greece [41] …”

Section: Introductionmentioning

confidence: 99%

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Detection and Treatment of Persistent Pollutants in Water: General Review of Pharmaceutical Products

2022

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Environmental problems of great complexity arise from the enormous number of toxic substances that are generated by anthropogenic activities. Seemingly, society encounters new issues every day thus these problems seem to be endless. Now in the face of the COVID‐19 pandemic and the SARS‐CoV‐2 crisis, a large number of emerging treatment compounds generated by pharmaceutical companies worldwide makes future issues even more treacherous. For this reason, there is an increasing need to detect and treat emerging compounds to prevent them from becoming persistent pollutants. This review describes the advances in the use of electrochemical sensors with modified carbon‐based electrodes among other issues, to determine antibiotics, anti‐inflammatories and antidepressants levels in the environment. It further explores technologies suggested for cleaning wastewater polluted by pharmaceutical products using biological or advanced oxidation processes including photolysis, photocatalysis, microwave heating, ultrasound, Fenton, electro‐Fenton, photoelectro‐Fenton and various combined treatments.

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Section: Antidepressantsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Detection and Treatment of Persistent Pollutants in Water: General Review of Pharmaceutical Products

2022

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“…Given the tertiary amine within the structure of AMT and its capacity to potentially act as a coreactant of tris(2,2′-bipyridyl)ruthenium(II), the sensitive ECL signal was generated through the AMT/Ru(bpy) 3 2+ reaction. Apart from this, AMT removal has also been explored via membrane, adsorption, , and even through advanced degradation processes, highlighting the need for pharmaceutical pollutant abatement. However, still, challenges remain for this amphiphilic species in terms of interference-tolerant selective recognition events.…”

Section: Introductionmentioning

confidence: 99%

Core-Labeled Reverse Micelle-Based Supramolecular Solvents for Assisted Quick and Sensitive Determination of Amitriptyline in Wastewater

Sharma,

Singh,

Kaur

et al. 2024

Langmuir

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In recent years, the issue of pharmaceutical contaminants in water bodies has emerged as a significant environmental concern owing to the potential negative impacts on both aquatic ecosystems and human health. Consequently, the development of efficient and eco-friendly methods for their determination and removal is of paramount importance. In this context, the development of a surfactant ensemble sensor has been explored for hard-to-sense amphiphilic drug, i.e., amitriptyline. Herein, a pyrene-based amphiphile chemoreceptor was synthesized and characterized through various spectroscopic techniques such as 1 H, 13 C NMR, single-crystal XRD, FTIR, and ES-mass spectrometry. Then, dodecanoic acid (DA) and a pyrene-based receptor in a THF/water solvent system were used to generate reverse micelle-based self-aggregates of SUPRAS (SUPRAmolecular Solvent). The structural aspects, such as morphology and size, along with the stability of the SUPRAS aggregates were unfolded through spectroscopic and microscopic insights. The present investigation describes a synergistic approach that combines the unique properties of premicellar concentration of supramolecular solvent with the promising potential of pyrene-based receptor for enhanced amitriptyline extraction with simultaneous determination from water (LOD = 12 nM). To evaluate the effectiveness of the developed aggregates in real-world scenarios, experiments were conducted to determine the sensing efficiency among various pharmaceutical pollutants commonly found in water sources. The results reveal that the synergistic nanoensemble exhibits remarkable sensing ability, toward the amitriptyline (AMT) drug outperforming conventional methods.

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“…Due to the high worldwide level of consumption, AMT has entered the aquatic environment through human excretion, expired drug disposal, and medical wastewater [ 6 , 15 , 16 ]. However, AMT is not biodegraded in wastewater treatment plants; it remails biologically active and persistent in aquatic environments and is considered a threat to wildlife [ 17 , 18 , 19 ].…”

Section: Introductionmentioning

confidence: 99%

Rapid Detection of Amitriptyline in Dried Blood and Dried Saliva Samples with Surface-Enhanced Raman Spectroscopy

Boroujerdi

Paul

Abdelkader

2022

Sensors

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There is growing demand for rapid, nondestructive detection of trace-level bioactive molecules including medicines, toxins, biomolecules, and single cells, in a variety of disciplines. In recent years, surface-enhanced Raman scattering has been increasingly applied for such purposes, and this area of research is rapidly growing. Of particular interest is the detection of such compounds in dried saliva spots (DSS) and dried blood spots (DBS), often in medical scenarios, such as therapeutic drug monitoring (TDM) and disease diagnosis. Such samples are usually analyzed using hyphenated chromatography techniques, which are costly and time consuming. Here we present for the first time a surface-enhanced Raman spectroscopy protocol for the detection of the common antidepressant amitriptyline (AMT) on DBS and DSS using a test substrate modified with silver nanoparticles. The validated protocol is rapid and non-destructive, with a detection limit of 95 ppb, and linear range between 100 ppb and 1.75 ppm on the SERS substrate, which covers the therapeutic window of AMT in biological fluids.

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Study of degradation of amitriptyline antidepressant by different electrochemical advanced oxidation processes

Cited by 27 publications

References 56 publications

Detection and Treatment of Persistent Pollutants in Water: General Review of Pharmaceutical Products

Detection and Treatment of Persistent Pollutants in Water: General Review of Pharmaceutical Products

Core-Labeled Reverse Micelle-Based Supramolecular Solvents for Assisted Quick and Sensitive Determination of Amitriptyline in Wastewater

Rapid Detection of Amitriptyline in Dried Blood and Dried Saliva Samples with Surface-Enhanced Raman Spectroscopy

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