Study of Developed Resistance Due to Antibiotic Treatment of Coagulase-Negative Staphylococci

Abstract

Coagulase-negative Staphylococci (CoNS) are a major cause of postoperative infections. These infections are often associated with foreign material implants and/or a compromised immune system in the patient. Multiresistant strains are increasingly common in the hospital environment and there is concern that the infections will become difficult or impossible to treat. This report is based on a study of 75 patients, with postoperative infections caused by CoNS after thoracic surgery. All patients were treated with surgical revision and antibiotic therapy. One or more bacterial cultures were made in each case, and the resistance pattern of the CoNS found was determined. The goal of the study was to evaluate possible relationships between antibiotic therapy and the appearance of resistance to antibiotics in CoNS found. To describe this relationship, three models were constructed and analyzed by multiple logistic regression. The results indicate an increased resistance to beta-lactam antibiotics and clindamycin after the use of cephalosporins. Also, the use of vancomycin or vancomycin in combination with rifampicin or fusidic acid increases the risk for development of resistance to beta-lactam antibiotics, ciprofloxacin, fusidic acid, clindamycin, netilmycin, and rifampicin. The hypothesis that a combination of antibiotics will curtail the development of resistance was not supported in this study.

Frequency of antiseptic resistance genes in clinical staphycocci and enterococci isolates in Turkey

“…Noguchi et al [ 22 ] detected qacA/B genes in 14.0% and smr genes in 28.0% of 71 clinical MRSA isolates in Japan. Alam et al [ 29 ] reported that in 522 clinical S. aureus isolates from a hospital in Japan, qacA/B was more prevalent in MRSA (32.6%) and more prevalent in MSSA (7.5%) than smr genes, which had a frequency of 3.3% in MRSA and 5.9% in MSSA.…”

Anti‐Inflammatory Activity of the Essential Oil Citral in Experimental Infection with Staphylococcus aureus in a Model Air Pouch

“…The high mortality rate related to staphylococcal infections [12], the increase in S. aureus isolates resistant to antibiotics [13], and frequent and prolonged exposure to antimicrobial agents hinder the treatment of infections [14]. Therefore, alternative strategies to prevent or treat infections caused by S. aureus , sometimes minimizing or supplementing use of antibiotics, are necessary.…”

Safety and pharmacokinetics of a chimerized anti-lipoteichoic acid monoclonal antibody in healthy adults

“…Recent reports [3][4][5] show continuing increases in staphylococcal resistance to currently available antimicrobial agents. Frequent and prolonged exposure to antimicrobials have been demonstrated to increase the risk of developing infections with resistant organisms [5,6]. Therapeutic products and strategies that could prevent infections would minimize the need for antimicrobial products and thereby potentially diminish the emergence of resistant organisms.…”