Study of Different Crystalline forms of Mannitol: Comparative Behaviour under Compression

Debord, B.; Lefèbvre, Chantal; Guyot-Hermann, A. M.; Hubert, Justine; Bouche, Raymond; Cuyot, J. C.

doi:10.3109/03639048709068679

Cited by 82 publications

(39 citation statements)

References 4 publications

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“…From the results of the evaluation test of the tablets it can be observed that mannitol is a good diluents as it forms smooth and relatively strong tablets which disintegrate easily and rapidly when come in contact with disintegrating fluid. This is probably due to its water soluble nature as suggested by Debord et al [16]. It was also observed that among the various disintegrants used such as Corn starch, Crospovidone, Croscarmellose Sodium and Sodium Starch Glycolate, Crospovidone shows relatively faster disintegration time at same concentration as compared to others.…”

Section: Resultssupporting

confidence: 50%

Oro-Dispersible Tablets of Ayurvedic Powder For improving Taste, Compliance, Ease and Accuracy of administration

Khobragde¹,

Kotha²,

Ravalika³

et al. 2016

Int J of Adv in Sci Res

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Most of the ayurvedic medicines are in the form of powder. Being in powder form the administration of accurate dose with ease is a problem. They may have some kind of unacceptable bitter taste. Furthermore it needs water or honey for administration and chances of spoilage and waste are more. Oro-dispersible tablet which rapidly disintegrating in mouth will be the best remedy for efficient use of ayurvedic powders. The aim of this study was to formulate oro-dispersible tablets of ayurvedic polyherbal powder Talisadi. Talisadi is a traditional Ayurvedic powder preparation well known and effective in various disorders of respiratory and digestive system. Using various excipients like super-disintegrants and sweeteners, different formulation of polyherbal drug Talisadi were formulated by direct compression method. The acceptable formulation, among all the developed formulations of oro-dispersible tablet was having a disintegrating time of 1 min and 10 sec and acceptable taste. Thus the study concludes that formulation of oro-dispersible tablets of ayurvedic powder preparation can be a good option to enhance acceptability, efficiency and easy and accurate administration of powder ayurvedic preparations like Talisadi.

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Section: Resultssupporting

confidence: 50%

Oro-Dispersible Tablets of Ayurvedic Powder For improving Taste, Compliance, Ease and Accuracy of administration

Khobragde¹,

Kotha²,

Ravalika³

et al. 2016

Int J of Adv in Sci Res

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“…Several crystallization reactions are reported for the production of δ-mannitol [8,9,10,11]. However, reproducible and scalable production of δ-mannitol by crystallization is difficult [8].…”

Section: Introductionmentioning

confidence: 99%

Continuous manufacturing of delta mannitol by cospray drying with PVP

Bockstal

Snick

Peeters

et al. 2016

International Journal of Pharmaceutics

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Mannitol is a frequently used diluent in the production of tablets due to its non-hygroscopic character and low drug interaction potential. Although the δ-polymorph of mannitol has superior tabletability in comparison to α-and β-mannitol, the latter are most commonly used because large-scale production of δ-mannitol is difficult. Therefore, a continuous method for production of δ-mannitol was developed in the current study. Spray drying an aqueous solution of mannitol and PVP in a ratio of 4:1 resulted in formation of δ-mannitol. The tabletability of a physical mixture of spray dried δ-mannitol with PVP (5%) and paracetamol (75%) was clearly superior to the tabletability of physical mixtures consisting of spray dried α-and β-mannitol with PVP (5%) and paracetamol (75%) which confirmed the excellent tableting properties of the δ-polymorph. In addition, a coprocessing method was applied to coat paracetamol crystals with δ-mannitol and PVP. The tabletability of the resulting coprocessed particles consisting of 5% PVP, 20% δ-mannitol and 75% paracetamol reached a maximal tensile strength of 2.1 MPa at a main compression pressure of 260 MPa. Moreover the friability of tablets compressed at 184MPa was only 0.5%. This was attributed to the excellent compression properties of δ-mannitol and the coating of paracetamol crystals with δ-mannitol and PVP during coprocessing.

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“…In addition, the use of a mannitol-producing L. lactis may result in fermented products with extra value, since mannitol is assumed to have several beneficial effects as a food additive. It can serve as an antioxidant (4,5,25,26) and as a low-calorie sweetener that can replace sucrose (6,8).In heterofermentative LABs such as Leuconostoc mesenteroides, mannitol is formed from fructose in a single conversion by mannitol dehydrogenase, and fructose-to-mannitol conversion rates of Ͼ90% are common (13,24,27). In contrast, most homofermentative LABs, such as Lactococcus lactis, do not normally produce mannitol.…”

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confidence: 99%

Overproduction of Heterologous Mannitol 1-Phosphatase: a Key Factor for Engineering Mannitol Production byLactococcus lactis

Wisselink

Moers

Mars

et al. 2005

Appl Environ Microbiol

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To achieve high mannitol production by Lactococcus lactis, the mannitol 1-phosphatase gene of Eimeria tenella and the mannitol 1-phosphate dehydrogenase gene mtlD of Lactobacillus plantarum were cloned in the nisindependent L. lactis NICE overexpression system. As predicted by a kinetic L. lactis glycolysis model, increase in mannitol 1-phosphate dehydrogenase and mannitol 1-phosphatase activities resulted in increased mannitol production. Overexpression of both genes in growing cells resulted in glucose-mannitol conversions of 11, 21, and 27% by the L. lactis parental strain, a strain with reduced phosphofructokinase activity, and a lactate dehydrogenasedeficient strain, respectively. Improved induction conditions and increased substrate concentrations resulted in an even higher glucose-to-mannitol conversion of 50% by the lactate dehydrogenase-deficient L. lactis strain, close to the theoretical mannitol yield of 67%. Moreover, a clear correlation between mannitol 1-phosphatase activity and mannitol production was shown, demonstrating the usefulness of this metabolic engineering approach.Mannitol is a reduced form of fructose and is produced by a variety of microorganisms including bacteria, yeasts, and fungi. Besides the ability of several organisms to maintain their redox balance by the production of mannitol (9, 21, 22), mannitol has a physiological function in microorganisms as an osmolyte (16) and can serve as a protecting agent. It has been reported that mannitol enhances survival of Lactococcus lactis cells during drying processes (10). The viability of starter cultures of L. lactis, a lactic acid bacterium (LAB) extensively used in dairy industry, may thus be enhanced by mannitol production. In addition, the use of a mannitol-producing L. lactis may result in fermented products with extra value, since mannitol is assumed to have several beneficial effects as a food additive. It can serve as an antioxidant (4,5,25,26) and as a low-calorie sweetener that can replace sucrose (6,8).In heterofermentative LABs such as Leuconostoc mesenteroides, mannitol is formed from fructose in a single conversion by mannitol dehydrogenase, and fructose-to-mannitol conversion rates of Ͼ90% are common (13,24,27). In contrast, most homofermentative LABs, such as Lactococcus lactis, do not normally produce mannitol. Mannitol formation in homofermentative LABs is limited to strains whose ability to regenerate NAD to fulfill the redox balance is severely hampered. In these strains, mannitol 1-phosphate dehydrogenase (M1PDH) and mannitol 1-phosphatase (M1Pase) are the enzymes involved in the mannitol biosynthesis route (Fig. 1). Transient formation of high concentrations of intracellular mannitol (90 mM) and mannitol 1-phosphate (76 mM) were detected in high-density nongrowing cell suspensions of a lactate dehydrogenase (LDH)-deficient L. lactis strain (22). During growth, only small amounts of mannitol (Ͻ0.4 mM) were transiently produced extracellularly (23). Recently, inactivation of the mannitol transport system in an LDH-def...

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Study of Different Crystalline forms of Mannitol: Comparative Behaviour under Compression

Cited by 82 publications

References 4 publications

Oro-Dispersible Tablets of Ayurvedic Powder For improving Taste, Compliance, Ease and Accuracy of administration

Oro-Dispersible Tablets of Ayurvedic Powder For improving Taste, Compliance, Ease and Accuracy of administration

Continuous manufacturing of delta mannitol by cospray drying with PVP

Overproduction of Heterologous Mannitol 1-Phosphatase: a Key Factor for Engineering Mannitol Production byLactococcus lactis

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