Study of Docosahexaenoic Acid and Eicosapentanoic Acid Effects on Some Biochemical Parameters in Epileptic patients

Ibrahim, Dania E.; Al-Hashemi, Wisam Kadhum H.; Alhussaini, Sajid Ibrahim

doi:10.5958/0974-360x.2020.00064.5

Rese. Jour. of Pharm. and Technol.

2020

DOI: 10.5958/0974-360x.2020.00064.5

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Study of Docosahexaenoic Acid and Eicosapentanoic Acid Effects on Some Biochemical Parameters in Epileptic patients

Dania E. Ibrahim¹,

Wisam Kadhum H. Al-Hashemi²,

Sajid Ibrahim Alhussaini³

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“…Numerous studies have examined the relationship between serum biomarkers and neurological disorders [12][13][14]. Serum levels of one biomarker, lactate, typically increase within the first few hours following a seizure.…”

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confidence: 99%

Correlation between Persistent Serum Lactate Elevation and Brain Magnetic Resonance Imaging Abnormalities in Children with Status Epilepticus

Gunawan,

Noviandi,

Samosir

2024

Ann Child Neurol

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Purpose: This study was conducted to evaluate the correlation between persistent serum lactate elevation and brain magnetic resonance imaging (MRI) in children with status epilepticus (SE). Methods: In this prospective analytical study, serum lactate levels were measured 24 hours after episodes of SE, and brain MRI was performed within 7 to 14 days after SE termination. MRI abnormalities were classified as acute encephalopathy (AE) grade I to III. The Kruskal-Wallis test was utilized for statistical analysis. Results: The study included 42 participants with SE, of whom 85.70% were boys, with a mean age of 4.94 years. Viral encephalitis was the most common diagnosis, accounting for 47.60% of cases. Elevated serum lactate levels were detected in 71.40% of patients, and approximately 47.60% exhibited abnormal MRI findings consistent with AE grade I. The median serum lactate levels for AE grades I, II, and III were 1.50, 3.10, and 0.78 mmol/L, respectively. Two patients died, and 66.70% experienced neurologic sequelae. A significant correlation (<i>P</i>=0.021) was observed between persistent serum lactate elevation and abnormal brain MRI findings. Conclusion: In children with SE, AE grade I was the most common neuroimaging pattern observed, and persistently elevated serum lactate level was correlated with abnormal brain MRI findings.

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mentioning

confidence: 99%

Correlation between Persistent Serum Lactate Elevation and Brain Magnetic Resonance Imaging Abnormalities in Children with Status Epilepticus

Gunawan,

Noviandi,

Samosir

2024

Ann Child Neurol

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In vivo Acetylcholinesterase activity and Antioxidant property of Cucurbita pepo ethanolic extract in Alzheimer’s disease induced by Aluminium chloride in Sprague Dawley rat model

Yadav

Shenoy

Kumar

et al. 2023

RJPT

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The pathophysiology of Alzheimer's disease (AD) typically begins before symptoms manifest. Early diagnosis and treatment can slow down the disease progression and improve the prognosis. Decreased acetylcholine, antioxidants, and polyunsaturated fatty acids enhance the progression of AD. Phytochemicals present in the Cucurbita pepo (C. pepo) plants may have anti-cholinesterase activity. Therefore, this study was performed using ethanolic extract of pumpkin seeds in the AlCl3 induced AD in Sprague Dawley rats. These rats were categorized into five groups, i.e., control, disease control (AlCl3), standard (Rivastigmine), and two treatment groups, one with 100mg/kg and the other with 200mg/kg of the pumpkin seed extract which was given once daily orally for 28days. The rats were assessed for behavioral and biochemical parameters such as antioxidant enzymes and acetyl-cholinesterase levels in brain homogenate. There was statistically significant (p<0.005) improvement in behavioral parameters and increase antioxidant levels and decrease acetylcholinesterase levels in the seed extract treatment groups compared to the AD rats. GC-MS analysis of C.pepo seeds showed the presence of polyunsaturated fatty acids, which have a significant role in neurite outgrowth activity. To conclude, the 80% ethanolic extract of Cucurbita pepo (pumpkin seeds) has anticholinesterase, antioxidant, and anti-inflammatory activity and can prevent memory impairment.

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Study of Docosahexaenoic Acid and Eicosapentanoic Acid Effects on Some Biochemical Parameters in Epileptic patients

Cited by 2 publications

References 0 publications

Correlation between Persistent Serum Lactate Elevation and Brain Magnetic Resonance Imaging Abnormalities in Children with Status Epilepticus

Correlation between Persistent Serum Lactate Elevation and Brain Magnetic Resonance Imaging Abnormalities in Children with Status Epilepticus

In vivo Acetylcholinesterase activity and Antioxidant property of Cucurbita pepo ethanolic extract in Alzheimer’s disease induced by Aluminium chloride in Sprague Dawley rat model

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