Study of Drug Resistant Pulmonary Tuberculosis

Deoskar, RB; SenGupta, Bandita; Rajan, KE; Barthwal,; Falleiro, Jjj; Sharma, SK

doi:10.1016/s0377-1237(05)80164-9

Cited by 4 publications

(3 citation statements)

References 11 publications

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“…However, a two-month waiting period before the first indications of treatment efficacy is very long and has implications for individual patients, control programs and clinical trials of new drugs. Moreover, the bacteria have time to adapt and develop drug tolerance 6 and resistance 7,8 during ineffective therapy.…”

Section: Introductionmentioning

confidence: 99%

Immune parameters as markers of tuberculosis extent of disease and early prediction of anti-tuberculosis chemotherapy response

Siawaya

Bapela

Ronacher

et al. 2008

Journal of Infection

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Section: Introductionmentioning

confidence: 99%

Immune parameters as markers of tuberculosis extent of disease and early prediction of anti-tuberculosis chemotherapy response

Siawaya

Bapela

Ronacher

et al. 2008

Journal of Infection

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“…In a study by Deoskar et al . [ 14 ] they found the MDR-TB in 65% of the cases and acquired drug resistance in 33.3% of the cases. The relationship between history of receiving anti-TB treatment and drug resistance has been clearly described in several studies.…”

Section: Discussionmentioning

confidence: 99%

“…The relationship between history of receiving anti-TB treatment and drug resistance has been clearly described in several studies. [ 7 14 15 ] This may indicate that acquired drug resistance could be a result of previous noncompliance. An alternative reason could be the transmission of TB strains from individuals infected with MDR-TB.…”

Section: Discussionmentioning

confidence: 99%

Profile of drug-resistant tuberculosis in Western Maharashtra

More¹,

Parande

Kamble³

et al. 2017

J Family Med Prim Care

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Context:Drug-resistant tuberculosis (TB) strains have evolved mainly due to incomplete or improper treatment of TB patients and are one of the hurdles in controlling TB problem. It is better to understand the magnitude and comorbidities associated with drug-resistant TB.Aim and Objectives:(1) To study some of the sociodemographic profile and history of TB treatment of drug-resistant TB cases. (2) To study their drug-resistance pattern and their comorbidity profile.Settings and Design:It was a record-based study descriptive, cross-sectional study of drug-resistant TB cases that were referred to State TB Training and Demonstration Centre (STDC).Materials and Methods:The data were collected by means of use of TB patient treatment register of those tested at STDC during first two quarters of the year 2012 (from January to June 2012). Sputum samples of all the cases were subjected to concentrated microscopy, and all positive samples were tested by GeneXpert and Line Probe Assay for drug susceptibility testing (DST) for isoniazid and rifampicin.Statistical Analysis:The findings were analyzed with Epi info7, using the mean, standard deviation, Chi-square test.Results:The mean age of the patients was 35.65 ± 13.59 years, majority 71.87% were males. The majority of patients 72.91% had the previous history of TB. A majority 68.75% of the patients had acquired drug resistance, and 73.95% of cases were suffering from multidrug-resistant TB. A total of 28.13% patients had self-reported comorbidity. A majority 62.5% had failure as the treatment outcome for the current episode of TB and mortality was seen in 12.5% cases.Conclusions:Majority had failure as a treatment outcome due to advanced disease status or late diagnosis. Rapid diagnosis and DST for first- and second-line drugs will greatly improve the clinical outcome.

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Baseline and end-of-treatment host serum biomarkers predict relapse in adults with pulmonary tuberculosis

Mutavhatsindi,

Manyelo,

Snyders

et al. 2024

Journal of Infection

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Study of Drug Resistant Pulmonary Tuberculosis

Abstract: Incidence of drug resistance was not as high as reported by some other workers and majority of the cases showed satisfactory outcome.

Cited by 4 publications

References 11 publications

Immune parameters as markers of tuberculosis extent of disease and early prediction of anti-tuberculosis chemotherapy response

Immune parameters as markers of tuberculosis extent of disease and early prediction of anti-tuberculosis chemotherapy response

Profile of drug-resistant tuberculosis in Western Maharashtra

Baseline and end-of-treatment host serum biomarkers predict relapse in adults with pulmonary tuberculosis

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