Study of drug utilization pattern and adverse drug reactions of psychotropic drugs in psychiatric inpatient department of tertiary care hospital

Abstract

Background: Mental disorders are now widely recognized as a major contributor to the global burden of disease. The drug use in psychiatric illness is a complex process and because of this the optimal benefits of drug therapy in patient care is not achieved. This often leads to increased cost of medical care, drug resistance, adverse effects and patient mortality. Hence, this study is undertaken to study the drug utilization pattern and adverse drug reactions of psychotropic drugs in psychiatric inpatient department of a tertiary care hospital.Methods: A prospective, observational study was undertaken from 1st February 2015 to 31st July 2016. A total of 250 prescriptions were analysed. Defined daily dose of the drugs were calculated. ADR’s were recorded in the format of the National Pharmacovigilance Programme of India (PvPI).Results: In 250 prescriptions most, common drug prescribed was antipsychotics (48.5%). Total drug utilization in terms of DDD/100 bed days was 669. The total number of adverse drug reactions observed was 8%. Antipsychotics were the most common class of psychotropic drugs causing ADR’s.Conclusions: In conclusion, it has been found that the psychotropic drugs used in our psychiatry department was rational and was based on clinical knowledge, expertise and the guidelines available in the field of psychiatric practice.

A study of adverse drug reactions and potential drug-drug interactions in the patients attending the Psychiatric Outpatient Department in a Tertiary Care Teaching Hospital: a cross-sectional study

“…Antipsychotics was the commonest group and olanzapine was the most common psychotropic drug suspected of causing ADRs in current study. This finding matched with the study conducted by Gurung et al (2018). Tremors (extrapyramidal symptoms) was the most common ADR observed due to psychotropic drugs in present study, which is in line with the findings reported by Prajapati et al (2013) and Gurung et al (2018).…”

“…This finding matched with the study conducted by Gurung et al (2018). Tremors (extrapyramidal symptoms) was the most common ADR observed due to psychotropic drugs in present study, which is in line with the findings reported by Prajapati et al (2013) and Gurung et al (2018). In present study, among the patients who had ADRs due to psychotropic drugs, the number of patients with causality assessment of ADRs as "possible" was more compared to the number of patients who had causality as "probable".…”

Quantifying and Categorizing ADRs in Psychiatric Residential Long-Stay Patients Utilizing UKU-SERS Scale

“… 24 Amantadine or propranolol were prescribed to these patients to provide relief from tremors. In contrast to these findings, a study conducted by Gurung et al 11 observed EPS as the most common ADR followed by sedation. This difference in the findings could be due to the difference in the prescribing pattern of psychotropic medications.…”

“…Several studies also indicate the same. 11 – 14 In our study population, maximum ADRs were observed because of atypical antipsychotics. The prescription pattern also revealed that the majority of patients received antipsychotics across all diagnostic categories.…”

“…This is in contrast to the findings of Gurung et al as prescription pattern may vary within different hospital settings. 11 Other classes of psychotropic drugs prescribed were mood stabilizers, antidepressants, anticonvulsants, benzodiazepines, other sedative-hypnotics, and CNS stimulants. None of the patients received depot psychotropic drugs.…”