Study of drug utilization pattern of antihyperglycemic agents in a South Indian tertiary care teaching hospital

Abstract

Objective:To determine the drug utilization pattern of antihyperglycemic agents (AHA) in a tertiary care teaching hospital.Materials and Methods:This was a prospective observational study. All the relevant data were collected and drug utilization pattern of AHA was determined. Direct cost associated with the use of antihyperglycemic medicines was calculated and consumption of the antihyperglycemic medicines was measured as defined daily dose (DDD)/100 bed-days. The adverse drug reactions (ADRs) related to anti-diabetic medicines were monitored.Statistical Analysis Used:Chi square test (χ2), mean±standard deviation.Results:During the study period, 350 patients diagnosed as diabetes mellitus (DM) were admitted. Insulin was prescribed as monotherapy to 81% and to 52% patients during hospital stay and discharge, respectively. Increase in utilization of insulin was recorded in majority of the patients due to presence of co-morbid conditions or resistance to oral hypoglycemic drugs. Use of insulin at the time of discharge decreased significantly (P<0.05) by 29%. Among the oral AHA, combination of glimepiride with metformin was more prevalent during hospital stay and at the time of discharge monotherapy of metformin followed by glimepiride was more prevalent. During hospital stay, cost of AHA was found to be Rs. 95.27 ± 119.03. The total antihyperglycemic drug consumption in the medicine ward during study period was 13.42 DDD/100 bed-days. Fifty ADRs were reported and descriptions of ADRs were found to be only hypoglycemia.Conclusion:The study exhibited a significant increase in the utilization of two drug combination therapies and monotherapy of oral AHA and decrease in the utilization of insulin at the time of discharge.

Evaluation of poison information services provided by a new poison information center

“…It also depends on the ability to locate, analyze and deliver the information required in a skillful, efficient and evidence-based manner to meet the needs of the requestor and document enquiries and information given in a clear and systematic manner. [8121314151719] Hence, we evaluated the quality of services provided by the center.…”

Utilization study of antidiabetic agents in a teaching hospital of Sikkim and adherence to current standard treatment guidelines

“…[ 4 ] A relative male preponderance was however noted in other studies. [ 5 6 ] The mean age of patients in this study was 59.85 ± 13.8 years. A study in Mysore reported the mean age of diabetics as 56.5 ± 13.2 years,[ 5 ] while another study in Spain reported it to be 60.5 ± 12.8 years in type 2 diabetics.…”

“…[ 5 6 ] The mean age of patients in this study was 59.85 ± 13.8 years. A study in Mysore reported the mean age of diabetics as 56.5 ± 13.2 years,[ 5 ] while another study in Spain reported it to be 60.5 ± 12.8 years in type 2 diabetics. [ 7 ] Patients in our study were observed to be mostly in the 61–70 years age range (27.1%) followed by 51–60 years (22.9%).…”

“…A similar pattern of insulin use was also observed in a study done in Mysore. [ 5 ] This may suggest that in patients with advanced diabetes and concomitant complications are more likely to require an insulin-based treatment regimen. Insulin is mostly indicated when optimal doses of oral hypoglycemic agents do not achieve target glycemic control, and deterioration of glycemic status is associated with substantial weight loss.…”

Adverse drug reaction monitoring during antimicrobial therapy for septicemia patients at a university hospital in New Delhi

“…Hence, females developed ADRs 3.6 times more often than males. It might be attributed that the females being more sensitive to the effect of drugs than the males [ 15 - 17 ]. Incidence of ADR was 1.6 times higher in patients, who were aged more than 60 years of age ( Table 4 ).…”