Study of effect of myoinositol on menstrual irregularities and skin problems in polycystic ovarian syndrome cases

Abstract

Background: Polycystic ovary syndrome (PCOS), first identified in 1935 as Stein-Leventhal syndrome, is a complex neuro-endocrine disorder affecting approximately 5% to 10% of women reproductive age. Typically PCOS is characterized by hyperandrogenism (extremely variable in its occurrence), chronic anovulation, polycystic ovaries at ultrasound evaluation and dermatological problems such as acne, hirsute and seborrhoea. PCOS is indeed the most common cause of female infertility.Methods: This prospective interventional study was conducted during December 2012 to June 2013 in Department of Obstetrics and Gynaecology at Pt. Jawaharlal Nehru Memorial Medical College and Associated Dr. Bhim Rao Ambedkar Memorial Hospital, Raipur (C.G.) India, after obtaining permission of ethical committee of institute. All young girls and married women who attended GOPD of Department of Obstetrics and Gynaecology having polycystic ovarian syndrome as defined by Rotterdam Criteria were registered and screened for inclusion in the study. At the end of three months’ data were compiled in MS-Excel and checked for its completeness and correctness then it was analysed suitable statistical test was applied and p-value <0.05 was considered statistically significant.Results: Maximum no of cases were between 21 to 25 yrs age, youngest one was of 15 yrs and oldest one was of 33 yrs. 72% cases belonged to urban area and only 28% cases belonged to rural area. 94.67% of cases were presented with abnormal menstrual cycle. The most common menstrual abnormality was Oligomenorrhoea (43.66%) followed by Oligomenorrhoea+Menorrhagia (21.13%) than Amenorrhoea (19.71%) and Hypomenorrhoea+Oligomenorrhoea (15.49%). 42.7% cases had oily skin, 26.7% cases had hirsutism, 20% cases had acne and 9.3% cases had acanthosis nigricans. 74.65% cases (53/75) were improved in their menstrual complaints; most common menstrual abnormality improved was Oligomenorrhoea+ Menorrhagia i.e. 88.67% (13/15). Out of all cases of oligomenorrhoea 77.4% cases (24/31) achieved regular menses. Out of all cases of oligomenorrhoea+ hypomenorrhoea 81.8%% cases (2/11) achieved regular menses.Conclusions: Present study confirms that Myoinositol, an insulin sensitizer, by improving insulin signalling reduces insulin resistance and improves menstrual irregularities and skin problems of PCOS cases.

Effect of Myoinositol and Metformin in combination on clinical and hormonal profile in patients of polycystic ovarian syndrome

“…16 Ranwa M et al, observed an improvement of only 33.3% in cases of acne, and an improvement of 34.4% in oily skin in cases of PCOS on administration of 2gm Myo per day. 19 This suggests that the additional effect of Metformin with myoinositol in the present study results in significant reduction of insulin levels, thereby reducing hyperandrogenism and its clinical consequences, as compared to myoinositol alone. Le Donne et al, Zacche et al, and Genazzani et al, observed significant improvement in Ferriman Galloway score.…”

“…6,9,11,16,18 A similar study conducted by Ranwa M et al using myoinositol alone for 12 weeks had a significantly lower improvement than present study. 19 Many studies suggest that insulin resistance is the causative factor for PCOS. HOMA index is a measure of the insulin resistance.…”

“…Various studies have found a success ranging from 22 to 88% in the management of PCOS. [13][14][15][16][17][18][19] Though the side effects are minimal, the cost of treatment with 2-4g/day for 3-6 months duration, is one of the major constraints.…”