Study of effects of metformin on C-reactive protein level in Type-2 diabetes mellitus

Abstract

Background: Diabetes mellitus (DM) is extremely common; represent a significant global health problem. Type-2 DM is considered to be associated with a low grade inflammation, which may play a significant role in development of cardiovascular complications evidenced by C-reactive protein (CRP) is a an extremely sensitive marker of systemic inflammation. The study was undertaken to check the effect of metformin on CRP level in Type-2 DM. Methods: The study was prospective and non-randomized. Thirty newly diagnosed Type-2 DM selected for metformin therapy by medicine personnel were enrolled in the study based on inclusion and exclusion criteria. Patients were divided into pretreatment (before starting metformin therapy) and post-treatment group. Fasting blood sugar (FBS), postprandial blood sugar (PP 2 BS), CRP level were measured at the time of enrolment and 3 months after starting metformin monotherapy. Results: Results were analyzed using pair t-test. Metformin therapy was found to decrease CRP level significantly along with FBS, PP 2 BS level. p<0.05 value considered as statistically significant. Value was expressed as mean ± standard deviation. Conclusions: Treatment with 3 months metformin monotherapy for newly diagnosed Type-2 DM has shown a significant decrease in high-sensitivity-CRP level in Type 2 diabetes. This positive effect may be because of the decreased in the expression of proinflammatory cytokines and other mediators, including adhesion molecules, suggests that these processes may contribute to atherogenesis because atherosclerosis is also an inflammatory condition. However, this effect is probably dependent on improving glycemic control.

Effect of Metformin on Circulating Levels of Inflammatory Markers in Patients With Type 2 Diabetes: A Systematic Review and Meta-analysis of Randomized Controlled Trials

“…Table 1 details the baseline characteristics of the 13 studies included in the meta-analysis. 15-18,26-34 A total of 13 articles representing 1776 participating patients with IGT and T2D were detected as appropriate literature for this meta-analysis. The study by Mo et al 26 was separated into 3 studies because they included different metformin treatment durations and dose levels.…”

“…Sensitivity analysis indicated that the removal of 2 studies (Gamit et al 34 and Mo et al 26 ) with low quality by means of "leave-one-out method" from the analysis of CRP ([SMD = −0.78 mg/L; 95% CI = −1.53, −0.027; P = 0.04), TNF-α (SMD = 0.09 mg/L; 95% CI = −0.52, 0.71; P = 0.77), and IL-6 (SMD = 0.18 mg/L; 95% CI = −0.52, 0.90; P = 0.60) did not change the results of the current pooled analysis for circulating levels of CRP, TNF-α, and IL-6 (Figure 3). Forest plot evaluating standardized mean difference (SMD) and 95% CIs for the impact of metformin treatment on circulating levels of (A) C-reactive protein, (B) tumor necrosis factor-α, and (C) interleukin-6 in patients with T2D.…”

Bipolar Spectrum Disorders in Male Youth: The Interplay between Symptom Severity, Inflammation, Steroid Secretion, and Body Composition

“…Metformin has further been shown to reduce measures of adiposity among overweight and obese adolescents with type 1 diabetes ( 88 ), to inhibit androgen biosynthesis ( 89 , 90 ), and to reduce inflammatory markers such as hsCRP and IL-6 ( 91 – 93 ). The anti-inflammatory medication Celecoxib may also be a promising adjunct as it has been found to promote an accelerated treatment response among acutely ill patients at early illness phase ( 18 ).…”

Serum Levels of C-Reactive Protein, Complement 3 and Complement 4 in Iraqi Diabetic Patients on Metformin Therapy

“…Since the previous studies investigated the role of the antidiabetic drug on inflammatory process, type-2 Diabetes Mellitus patients showed a decreased level of CRP after taking the metformin. 10 Overall, metformin plays a crucial role to reduce the CRP concentration which contributes to reduce the inflammation and prevent the development of cardiovascular complications. 11,12 Negligible inflammation can trigger classical pathway of the complement system, which is composed of subunits protein found in the blood.…”