Study of efficacy of mifepristone as inducing agent for mid trimester medical termination of pregnancy in women with previous cesarean section

Chikkagowdra, Shaila; Doddaiah, Vanaja; Cm, Veerendrakumar

doi:10.18203/2320-1770.ijrcog20162983

Cited by 2 publications

(2 citation statements)

References 20 publications

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“…There was no incidence of uterine rupture in our study. It is comparable to previous study by Chikkagowdra [14] . Thus, both the regimens used in our study were effective method for termmination of pregnancy with Mifepristone group having statistically signifiant induction abortion interval.…”

Section: Discussionsupporting

confidence: 92%

Use of mifepristone plus misoprostol vs cerviprime plus misoprostol for second trimester abortion: A prospective comparative study

Singh¹,

Saha²,

Aziz³

et al. 2019

Int. J. Clin. Obstet. Gynaecol.

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Background: The complications of abortion increase with the advancing gestational age. The search for the best and most reliable method for second trimester abortion is still ongoing. A prospective comparative study was conducted at a tertiary care hospital in Delhi from 01 Sep 2017 to 31 Aug 2018 with an aim to find out an effective method of second trimester abortion within reasonable time and fewer complications. Study: A total of 70 patients were studied to compare combination of Mifepristone and misoprostol Vs cerviprime and misoprostol for second trimester abortion. The end point of the study was complete abortion with expulsion of placenta. The Induction abortion interval, success rate, side effects and complications were compared between the two groups. Results: There was a significant difference in the IAI in both the groups. The mean Induction to abortion interval was 10.7 hrs in the Mifepristone + misoprostol group and 13.7 hrs in the Cerviprime + misoprostol group. The success rate was 100% in each arm, none of the patients required hysterotomy. More side effects were seen in the cerviprime + misoprostol group. Conclusions: Mifepristone followed by misoprostol and Cerviprime followed by misoprostol are effective methods for second trimester abortion, but mifepristone + misoprostol has the advantage of having lesser Induction to abortion interval and fewer side effects.

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Section: Discussionsupporting

confidence: 92%

Use of mifepristone plus misoprostol vs cerviprime plus misoprostol for second trimester abortion: A prospective comparative study

Singh¹,

Saha²,

Aziz³

et al. 2019

Int. J. Clin. Obstet. Gynaecol.

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“…However, the change seen after 24 hours and 48 hours was nearly similar, 1.72 ± 0.72 vs. 1.78 ± 081, and on comparison of this p-value received >0.05. Similarly, a single arm study conducted by Chikkagowdra S et al for second-trimester abortion in previous LSCS females also showed improvement in Bishop score ( 14 ).…”

Section: Discussionmentioning

confidence: 70%

Comparison of Two Different Intervals of Misoprostol Administration in Second Trimester Abortions

Gupta,

Gautam,

Chanana

et al. 2023

JFRH

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Objective: Comparison of two different intervals of misoprostol administration after mifepristone in second trimester abortions. Materials and methods: This 12-month prospective study was conducted at a tertiary care facility. Only pregnancies with congenital deformity or sterilisation failure were included in the study's recruitment of 100 women who visited the hospital for a second trimester abortion between 12 and 20 weeks; cases with scarred uteri were omitted. In a systematic random selection of 50 women in each group, the administration of 200 mg of mifepristone orally was followed by two distinct intervals of intravaginal misoprostol administration at 24- and 48-hour intervals. After 24 hours, group A women received intravaginal 400 mcg misoprostol three hourly, up to a maximum of five doses, while group B received the same doses after 48 hours. Induction abortion interval noted on various parameters and paired t test and chi square test applied. Results: The mean IAI following misoprostol administration was 8.14 2±.03 hours in group A and 7.71 ±2.56 hours in group B. This difference was statistically insignificant. Average misoprostol doses for group A were 1.68±0.71 and for the group, B were 1.68±0.84; both doses were found to be statistically insignificant when used to induce abortion. All women aborted successfully in each group. There was no significant difference in side effects in both groups. Conclusion: Based on the results it was observed that shorter interval between mifepristone and misoprostol i.e., 24 hours can be chosen to decrease the hospital stay as there was no significant difference was seen after intravaginal misoprostol in terms of induction abortion interval, number of doses and side effects.

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Study of efficacy of mifepristone as inducing agent for mid trimester medical termination of pregnancy in women with previous cesarean section

Cited by 2 publications

References 20 publications

Use of mifepristone plus misoprostol vs cerviprime plus misoprostol for second trimester abortion: A prospective comparative study

Use of mifepristone plus misoprostol vs cerviprime plus misoprostol for second trimester abortion: A prospective comparative study

Comparison of Two Different Intervals of Misoprostol Administration in Second Trimester Abortions

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