Study of Efficiency of 3-Oxypiridine Derivatives in Correction of Disorders in the Conditions of Experimental Preeclampsia

Abstract

The pathogenesis of preeclampsia is polyetiologic and not fully understood. One of the leading theories of pathogenesis is the theory of oxidative stress. Accordingly, the search for new drugs with antioxidant and antihypoxic effects is promising for the prevention and treatment of preeclampsia. Methods. The experiment was performed on 140 female white rats of Wistar strain weighing 250-300 g. The studied substances were administered within 7 days from 14 to 21 days of pregnancy. On the 21st day of pregnancy, functional tests were conducted. Results. Administration of 3-oxypiridine derivates in animals causes the expressed correction of pathological changes in experimental ADMA-like preeclampsia. There was a significant rise in systolic and diastolic blood pressure, respectively, the improvement of microcirculation in the placenta, restoration of endothelium NO-synthesis function, proteinuria reduction. Conclusion. The results of this study prove the future outlook of the use of 3-oxypiridine derivates for correction of functional changes in preeclampsia and substantiate the reasonability of further research in this direction.