Study of EGCG composite hydrogel for the treatment of radiation-induced skin injuries

Abstract

With the rising incidence of cancer, radiotherapy has become an increasingly popular treatment modality. However, radiation-induced skin injuries (RSIs) have emerged as a commonly reported side effect of radiotherapy, thereby presenting a significant challenge in the field of radiotherapy. In this study, we report the successful synthesis of a photosensitive hydrogel via amide reaction for grafting the photosensitive group, methacrylate anhydride (MA), onto chitosan (CHI) and gelatin (GEL), with subsequent physical incorporation of epigallocatechin gallate (EGCG). The resulting composite photosensitive hydrogels exhibited favorable swelling properties, rheological properties, and biocompatibility, which promote angiogenesis and demonstrate notable therapeutic efficacy against RSIs. These findings provide valuable insights into the clinical utility of EGCG composite hydrogels for the effective management of RSIs.

Application of In Situ Mucoadhesive Hydrogel with Anti-Inflammatory and Pro-Repairing Dual Properties for the Treatment of Chemotherapy-Induced Oral Mucositis

“…The highly porous structure of the hydrogels facilitates nutrient transport and oxygen diffusion, supporting cell proliferation and migration essential for wound healing and soft tissue regeneration . Pore size is a critical parameter for hydrogels, influenced by factors such as polymer type, preparation method, and concentration of the cross-linking agent . The pore sizes of Col, Col/HA-E, and Col/HA-E/Alg hydrogels were measured to be 48.9 ± 20.1, 81.5 ± 23.4, and 81.1 ± 29.4 μm, respectively, as depicted in Figure S2.…”

“…The addition of 1% HA-E increased the pore size of the hydrogels, while 0.5% AlgDA-MA had a lesser effect on the pore size. Research indicates that hydrogels with pore sizes up to 50 μm are unable to transport oxygen and nutrients effectively . Conversely, hydrogels with pore sizes exceeding 80 μm are favorable for angiogenesis, cell proliferation, and migration .…”

High Added-Value by-Products from Biomass: A Case Study Unveiling Opportunities for Strengthening the Agroindustry Value Chain

“…One of the most substantial portions of banana waste is the stem (peduncle), the central part of the bunch (inflorescence) where the amount of palms (cluster) is attached. The stem is rich in a flavonoids belonging to the catechin class, such as epigallocatechin gallate (EGCG) (Figure 3), an antioxidant, antiinflammatory, and anticancer substance, used for skin lesions and for reducing Alzheimer's disease pathology [62][63][64]. EGCG was also already described to aid in the treatment of metabolic syndrome, obesity, diabetes, and hypertension [65].…”