Study of electrochemical oxidation and determination of albendazole using a glassy carbon-rotating disk electrode

Santos, André Luíz dos; Takeuchi, Regina M.; Mariotti, Marcela P.; Oliveira, Marcelo Firmino de; Zanoni, María Valnice Boldrin; Stradiotto, Nelson Ramos

doi:10.1016/j.farmac.2005.05.004

Cited by 21 publications

(17 citation statements)

References 14 publications

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“…Though AB presents activity against many intestinal parasites, the use to combat larval forms of Taenia solium, that is associated to neurocysticercosis, a brain infection is one of its therapeutic applications of utmost importance [7,8].…”

Section: Figurementioning

confidence: 99%

Differential Pulse Voltammetric Determination of Albendazole and Mebendazole in Pharmaceutical Formulations Based on Modified Sonogel Carbon Paste Electrodes with Perovskite-Type LaFeO₃Nanoparticles

Macêdo

Garcia

Souza

et al. 2016

J. Electrochem. Soc.

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Section: Figurementioning

confidence: 99%

Differential Pulse Voltammetric Determination of Albendazole and Mebendazole in Pharmaceutical Formulations Based on Modified Sonogel Carbon Paste Electrodes with Perovskite-Type LaFeO₃Nanoparticles

Macêdo

Garcia

Souza

et al. 2016

J. Electrochem. Soc.

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“…The drug is official in British Pharmacopoeia [3], which describes a potentiometric titration with perchloric acid in formic acidacetic acid medium. Quantitative determination of ALB in dosage forms has received wide attention and several methods have been reported and include titrimetry in nonaqueous medium [4,5], redox titrimetry [6][7][8][9][10][11][12], UV spectrophotometry [13][14][15][16][17], spectrofluorimetry [18,19], voltammetry [20][21][22], high performance liquid chromatography [23][24][25][26][27], and high performance thin layer chromatography [28,29].…”

Section: Introductionmentioning

confidence: 99%

Use of Two Sulfonphthalein Dyes for the Sensitive and Selective Extraction-Free Spectrophotometric Assay of Albendazole in Bulk Drug and in Tablets

Swamy

Basavaiah

2013

ISRN Analytical Chemistry

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Albendazole (ALB) is a potent benzimidazole anthelmintic used in the treatment of human intestinal helmintiasis as well as of hytatid cysts and neurocysticercosis. Two rapid, simple, sensitive, and selective spectrophotometric methods are presented for the determination of ALB in pharmaceuticals. The methods are based on the formation of dichloromethane soluble 1 : 1 ion-pair complexes (ALB : dye) formed between ALB and sulfonphthalein dyes, bromophenol blue BPB, (method A) and bromothymol blue BTB, (method B). The complexes formed were measured directly (without extraction) at 445 nm (method A) and 460 nm (method B). The experimental conditions were optimized and the systems obey Beer’s law for 1.5–21.0 and 2.0–32.0 μg mL−1 ALB for method A and method B respectively. The molar absorptivity and Sandell's sensitivity were calculated to be L mol−1 cm−1 and 0.0209 ng cm−2, and L mol−1 cm−1 and 0.0350 ng cm−2 using BPB and BTB, respectively. The limits of detection and quantification were calculated to be 0.01 and 0.03, and 0.16, and 0.49 μg mL−1 using BPB and BTB, respectively. The relative standard values for intra-day and inter-day precision were less than 3%, and the accuracy was better than 3% for both methods.

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“…Hydrodynamic conditions strongly improve the mass transport due to the forced convection and as a consequence, higher current values are obtained allowing the development of more sensible electroanalytical methods which have been successfully used for determination of drugs in pharmaceutical formulations. 16,18,44,45 Another advantage presented by amperometric detection is the shorter time of analysis because is not necessary to register a complete voltammogram. This advantage becomes more evident when amperometric detection is compared with differential pulse voltammetry which requires relatively low scan rates.…”

Section: Analytical Applicationsmentioning

confidence: 99%

“…9,10 In general, electroanalytical methods offer high sensitivity with low detection limit, easy operation and sometimes the use of simple and non-expensive instrumentation. Thus, the advantageous characteristics of the electrochemical techniques have allowed their use for determination of a wide range of pharmaceuticals compounds using mercury, [11][12][13][14] glassy carbon, [15][16][17] carbon paste, 18,19 and chemically modified electrodes. [20][21][22][23] Despite of the relevance of electrochemical techniques on the study of pharmacological compounds, there are no reports of electrochemical studies of TEC until now.…”

Section: Introductionmentioning

confidence: 99%

Study of the electrochemical reduction of amoebicide teclozan and its amperometric determination in pharmaceutical formulations

Santos¹,

Takeuchi²,

Stradiotto³

et al. 2008

J. Braz. Chem. Soc.

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Neste trabalho, a redução eletroquímica do amebicida Teclozan (TEC) foi estudada sobre um eletrodo de carbono vítreo em meio de acetonitrila. Eletrólises com potencial controlado foram realizadas visando, tanto a determinação do número de elétrons envolvidos na redução do fármaco, quanto a identificação dos produtos eletrogerados, os quais foram isolados por extração líquido-líquido e caracterizados por 1 H RMN. Foi verificado que o TEC apresenta dois picos voltamétricos, cada um associado à quebra redutiva de duas ligações C-Cl. Em presença de um doador de prótons, foi observado que o primeiro pico voltamétrico em −1,8 V corresponde principalmente à redução dos grupamentos -CHCl 2 a -CH 2 Cl; enquanto o segundo pico em −2,2 V é responsável pela redução dos grupos -CH 2 Cl a CH 3 , fornecendo como único produto o derivado totalmente desalogenado do TEC, com rendimentos entre 82 e 97%. Este trabalho descreve também o desenvolvimento de um método eletroanalítico baseado na detecção amperométrica do TEC em condições hidrodinâmicas, o qual forneceu um limite de detecção de 8,9 × 10 -6 mol L -1 .The electrochemical reduction of amoebicide Teclozan (TEC) was studied on a glassy carbon electrode in acetonitrile. Controlled-potential electrolyses were performed for coulometric and preparative purposes. The electrogenerated products were isolated by liquid-liquid extraction and characterized by 1 H NMR. It was observed that TEC presents two voltammetric peaks, each one associated with the cleavage of two C-Cl bonds. In presence of a proton donor it was observed that the first peak at −1.8 V promotes mainly the reduction of the groups CHCl 2 to CH 2 Cl and the second one at −2.2 V promotes the reduction of the groups CH 2 Cl to CH 3 giving as the sole product the completely dechlorinated TEC derivative with yields between 82 and 97%. In addition, a comparative study between the analytical performance of voltammetric techniques and amperometric detection of TEC in hydrodynamic conditions was performed. The amperometric detection was more sensitive than all evaluated voltammetric techniques, providing a detection limit of 8.9 × 10 -6 mol L -1 .

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Study of electrochemical oxidation and determination of albendazole using a glassy carbon-rotating disk electrode

Cited by 21 publications

References 14 publications

Differential Pulse Voltammetric Determination of Albendazole and Mebendazole in Pharmaceutical Formulations Based on Modified Sonogel Carbon Paste Electrodes with Perovskite-Type LaFeO₃Nanoparticles

Differential Pulse Voltammetric Determination of Albendazole and Mebendazole in Pharmaceutical Formulations Based on Modified Sonogel Carbon Paste Electrodes with Perovskite-Type LaFeO₃Nanoparticles

Use of Two Sulfonphthalein Dyes for the Sensitive and Selective Extraction-Free Spectrophotometric Assay of Albendazole in Bulk Drug and in Tablets

Study of the electrochemical reduction of amoebicide teclozan and its amperometric determination in pharmaceutical formulations

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Study of electrochemical oxidation and determination of albendazole using a glassy carbon-rotating disk electrode

Cited by 21 publications

References 14 publications

Differential Pulse Voltammetric Determination of Albendazole and Mebendazole in Pharmaceutical Formulations Based on Modified Sonogel Carbon Paste Electrodes with Perovskite-Type LaFeO3Nanoparticles

Differential Pulse Voltammetric Determination of Albendazole and Mebendazole in Pharmaceutical Formulations Based on Modified Sonogel Carbon Paste Electrodes with Perovskite-Type LaFeO3Nanoparticles

Use of Two Sulfonphthalein Dyes for the Sensitive and Selective Extraction-Free Spectrophotometric Assay of Albendazole in Bulk Drug and in Tablets

Study of the electrochemical reduction of amoebicide teclozan and its amperometric determination in pharmaceutical formulations

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Differential Pulse Voltammetric Determination of Albendazole and Mebendazole in Pharmaceutical Formulations Based on Modified Sonogel Carbon Paste Electrodes with Perovskite-Type LaFeO₃Nanoparticles

Differential Pulse Voltammetric Determination of Albendazole and Mebendazole in Pharmaceutical Formulations Based on Modified Sonogel Carbon Paste Electrodes with Perovskite-Type LaFeO₃Nanoparticles