Study of Electrolyte Changes in Tuberculosis And Human Immune Deficiency Virus (HIV) Co-Infected with Tuberculosis Patients : A Hospital Based Study

Bhagyamma, S.N.; Sreeenivasulu, Dr.U.; Ray, Anuradha

doi:10.9790/0853-1509102831

Cited by 2 publications

(1 citation statement)

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“…[ 5 ] in Southwestern Nigeria and Bhagyamma et al . [ 6 ] in India where patients with new TB infection had lower serum levels of potassium. Mycobacterium tuberculosis has a unique transcriptional response to changes in potassium levels both intra-mycobacteria and extra-mycobacteria [ 11 ].…”

Section: Discussionmentioning

confidence: 99%

Biochemical changes in tuberculosis

Ufoaroh¹,

Onwurah²,

Mbanuzuru³

et al. 2021

Pan Afr Med J

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Introduction tuberculosis (TB) remains a global health issue with high morbidity and mortality rates especially in the developing countries. It is a multi-organ disease and can influence biochemical changes. This study sought to determine the influence of tuberculosis and its drug treatment on serum biochemical parameters in patients in Nigeria. Methods it was a descriptive observational cohort study on 150 subjects whose blood samples were analyzed for serum albumin, serum sodium, and serum potassium. The subjects were grouped into 3: TB group= 50 new TB subjects not on treatment, F group= 50 TB subjects on treatment for 2/12 or more and C group= 50 non-TB control subjects. These biochemical variables were compared between the 3 groups. Results male/female ratio was 1: 1.5, mean age 37.1±0.92 years, and range 18-65 years. The differences in mean values of serum albumin, calcium and sodium between the three groups were significant (p<0.001), whereas that of serum potassium was not significant (p=0.056). Those patients with new case TB had a significantly lower serum sodium, serum albumin and serum calcium than the control group and those on treatment, p<0.001. There was significant positive correlation between serum albumin and serum calcium (r=0.0.420, p<0.001) as well as serum sodium (r=0.310, p<0.001) in the study population. Similarly, the correlation between serum calcium and serum sodium was positive and significant (r=0.200, p=0.014). In contrast, the correlation between serum potassium and serum albumin and that between serum potassium and serum calcium was not significant. Conclusion tuberculosis with or without anti-tuberculous medications was associated with significant reduction in serum albumin, serum sodium and serum calcium in this study.

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Section: Discussionmentioning

confidence: 99%