Study of elution characteristics of anti-tuberculosis drugs mixed with bone cement

Abstract

The objective: to assess the elution characteristics of anti-tuberculosis drugs (isoniazid, cycloserine, rifampicin, amikacin, kanamycin, ethambutol) placed into bone cement samples and put in a liquid medium to determine the possibility of using such systems as a drug reservoir.Subjects and methods. For in vitro studies, pure substances of the drugs were used. The spectrophotometry was used to study the elution kinetics of the drugs. Absorption spectra of the drugs in the visible and ultraviolet regions were analyzed to reveal the absorption maxima, and the resistance of the chemical structure of the drugs to heating was assessed. Further, the changes of drug release from hardened bone cement samples under static conditions were studied.Results. It has been found that studied drugs demonstrated satisfactory parameters of thermal stability and elution which makes it possible to use them in a mixture with bone cement.

Prospects for Adding Drugs with Known Anti-tuberculosis Activity to the Composition of Bone Cement for Treatment of Tuberculous Arthritis

“…Были поставлены две серии экспериментов, где на 40 г костного цемента бралось 2 и 3 г пре-парата. Элюционные характеристики амикацина были изучены нами в предыдущем исследовании [1]. Полученные после полимеризации цилиндры помещались в 30 мл фосфатно-солевого раствора и инкубировались при температуре 37 ± 1°С.…”