Study of encapsulation of polyphenols on succinyl-chitosan nanoparticles

Palacio, J.; Monsalve, Yuliana; Ramírez-Rodríguez, Frank; López, Bety

doi:10.1016/j.jddst.2020.101610

Cited by 17 publications

(7 citation statements)

References 27 publications

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“…Palacio et al (2020) recently reported the use of succinyl-chitosan NPs to encapsulate phenolic compounds. They explained that succinyl-chitosan NPs made a strong interaction with phenolic compounds and improved both their solubility and encapsulation efficiency (Palacio et al, 2020). Another study proposed the encapsulation of extracted phenolic compounds from red grape and golden apple pomace in chitosan and soy protein (Gaber Ahmed et al, 2020).…”

Section: Strategies To Overcome Stability and Solubility Barriers Of ...mentioning

confidence: 99%

“…Chitosan NPs have many advantages including enhanced stability of compounds and improved compound solubility. Palacio et al (2020) recently reported the use of succinyl-chitosan NPs to encapsulate phenolic compounds. They explained that succinyl-chitosan NPs made a strong interaction with phenolic compounds and improved both their solubility and encapsulation efficiency (Palacio et al, 2020).…”

Section: Strategies To Overcome Stability and Solubility Barriers Of ...mentioning

confidence: 99%

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Naturally occurring phenolic compounds as promising antimycotoxin agents: Where are we now?

Ahmed

Tardif

Rouger

et al. 2022

Comp Rev Food Sci Food Safe

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Mycotoxins are metabolites produced by molds that contaminate food commodities, are harmful to both humans and animals, as well as cause economic losses. Many countries have set regulatory limits and strict thresholds to control the level of mycotoxins in food and feedstuffs. New technologies and strategies have been developed to inhibit toxigenic fungal invasion and to decontaminate mycotoxins. However, many of these strategies do not sufficiently detoxify mycotoxins and leave residual toxic by‐products. This review focuses on the use of phenolic compounds obtained from botanical extracts as promising bioagents to inhibit fungal growth and/or to limit mycotoxin yields. The mechanism of these botanicals, legislation concerning their use, and their safety are also discussed. In addition, recent strategies to overcome stability and solubility constraints of phenolic compounds to be used in food and feed stuffs are also mentioned.

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Section: Strategies To Overcome Stability and Solubility Barriers Of ...mentioning

confidence: 99%

Section: Strategies To Overcome Stability and Solubility Barriers Of ...mentioning

confidence: 99%

Naturally occurring phenolic compounds as promising antimycotoxin agents: Where are we now?

Ahmed

Tardif

Rouger

et al. 2022

Comp Rev Food Sci Food Safe

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“…The spectra of the extract of the polyphenols (sample P) and of the substrate (HAp) were used as a reference. The curves are presented in Figure A, and the peaks are interpreted thanks to previous works. − …”

Section: Resultsmentioning

confidence: 99%

Polyphenols from Grape Pomace: Functionalization of Chitosan-Coated Hydroxyapatite for Modulated Swelling and Release of Polyphenols

et al. 2021

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Chitosan is known for its specific antibacterial mechanism and biodegradability, while polyphenols are known for their antioxidant and anti-inflammatory properties: coupling these properties on a surface for bone contact, such as hydroxyapatite, is of great interest. The system developed here allows the combination of hydroxyapatite, chitosan, and polyphenol properties in the same multifunctional biomaterial in order to modulate the host response after implantation. Crosslinked chitosan is used in this research to create a stable coating on hydroxyapatite, and then it is functionalized for a smart release of the polyphenols. The release is higher in inflammatory conditions and lower in physiological conditions. The properties of the coated and functionalized samples are characterized on the as-prepared samples and after the samples are immersed (for 24 h) in solutions, which simulate the inflammatory and physiological conditions. Characterization is performed in order to confirm the presence of polyphenols grafted within the chitosan coating, the stability of grafting as a function of pH, the morphology of the coating and distribution of polyphenols on the surface, and the redox reactivity and radical scavenging activity of the functionalized coating. All the results are in line with previous results, which show a successful coating with chitosan and functionalization with polyphenols. Moreover, the polyphenols have a different release kinetics that is faster in a simulated inflammatory environment compared to that in the physiological environment. Even after the release tests, a fraction of polyphenols are still bound on the surface, maintaining the antioxidant and radical scavenging activity for a longer time. An electrostatic bond occurs between the negative-charged polar groups of polyphenols (carboxyls and/or phenols) and the positive amide groups of the chitosan coating, and the substitution of the crosslinker by the polyphenols occurs during the functionalization process.

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“…As a drug carrier, N-succinyl-CS can readily prepare drug conjugates with various drugs due to-H 2 and -COOH groups in its structure [20,35]. Palacio et al [36] prepared succinyl-chitosan (SCS) nanoparticles by the ionic crosslinking method for polyphenols encapsulation and theoretically studied the interaction between SCS and polyphenols. Modification of CS with succinyl groups was carried out through the reaction between the -NH 2 groups within the CS structure and succinic anhydride.…”

Section: Ionic Chitosan Derivatives (With Cationic and Anionic Substituents)mentioning

confidence: 99%

Advances in Chitosan-Based Nanoparticles for Drug Delivery

Mikušová

Mikuš

2021

IJMS

295

120

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Nanoparticles (NPs) have an outstanding position in pharmaceutical, biological, and medical disciplines. Polymeric NPs based on chitosan (CS) can act as excellent drug carriers because of some intrinsic beneficial properties including biocompatibility, biodegradability, non-toxicity, bioactivity, easy preparation, and targeting specificity. Drug transport and release from CS-based particulate systems depend on the extent of cross-linking, morphology, size, and density of the particulate system, as well as physicochemical properties of the drug. All these aspects have to be considered when developing new CS-based NPs as potential drug delivery systems. This comprehensive review is summarizing and discussing recent advances in CS-based NPs being developed and examined for drug delivery. From this point of view, an enhancement of CS properties by its modification is presented. An enhancement in drug delivery by CS NPs is discussed in detail focusing on (i) a brief summarization of basic characteristics of CS NPs, (ii) a categorization of preparation procedures used for CS NPs involving also recent improvements in production schemes of conventional as well as novel CS NPs, (iii) a categorization and evaluation of CS-based-nanocomposites involving their production schemes with organic polymers and inorganic material, and (iv) very recent implementations of CS NPs and nanocomposites in drug delivery.

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Study of encapsulation of polyphenols on succinyl-chitosan nanoparticles

Cited by 17 publications

References 27 publications

Naturally occurring phenolic compounds as promising antimycotoxin agents: Where are we now?

Naturally occurring phenolic compounds as promising antimycotoxin agents: Where are we now?

Polyphenols from Grape Pomace: Functionalization of Chitosan-Coated Hydroxyapatite for Modulated Swelling and Release of Polyphenols

Advances in Chitosan-Based Nanoparticles for Drug Delivery

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