Amidst a global discourse on energy resources, it is imperative to provide decision makers with a comprehensive overview of energy consumption (EC) associated with various projects, particularly wastewater treatment plants (WWTPs). Ensuring compliance with stringent effluent quality criteria in the treatment of municipal wastewater necessitates a substantial EC, representing a predominant factor contributing to the operational expenses incurred by WWTP. Machine learning (ML) techniques can contribute to the estimation of the WWTPs’ EC, which requires efficient and accurate data. This article uses data from several municipal WWTP projects in Greece, which are examined in order to produce EC estimation models. Data were first statistically analyzed, according to the context of project attributes and the context of EC, and correlation analysis identified the appropriate predictive project variables. Then, the attribute selection function in Waikato Environment for Knowledge Analysis 3.8.4 (WEKA 3.8.4) software emphasized the most effective subset of variables. The extracted variables from the combination of the correlation analysis and the WEKA attribute function were used as input neurons for the construction of neural network (NN) models, in the Fast Artificial Neural Network Tool 1.2 (FANN Tool 1.2). The optimum NN model resulted in a mean squared error (MSE) of 8.99899 × 10−5 and was based on treatment capacity, flow rate, influent load, and served population as its inputs. Notably, the research highlights the potential generalizability of these models in Greece and beyond the Greek context, offering valuable tools for stakeholders to inform decision making, allocate resources efficiently, and improve energy-efficient designs, resulting in cost savings and sustainability benefits.